Viral Proteases and Their Inhibitors

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  • Publisher : Academic Press
  • Release : 03 July 2017
  • ISBN : 9780128096826
  • Page : 516 pages
  • Rating : 4.5/5 from 103 voters

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Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

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Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2017-07-03
  • ISBN : 9780128096826
GET THIS BOOKViral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the

Antiviral Strategies

Antiviral Strategies
  • Author : Hans-Georg Kräusslich,Ralf Bartenschlager
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-02
  • ISBN : 9783540790860
GET THIS BOOKAntiviral Strategies

A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development

Retroviral Proteases

Retroviral Proteases
  • Author : Lawrence C. Kuo,Jules A. Shafer
  • Publisher : Gulf Professional Publishing
  • Release Date : 1994-09-22
  • ISBN : 0121821420
GET THIS BOOKRetroviral Proteases

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases
  • Author : Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk
  • Publisher : Springer
  • Release Date : 2018-05-22
  • ISBN : 9783319754741
GET THIS BOOKActivation of Viruses by Host Proteases

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in

Viral Proteases and Antiviral Protease Inhibitor Therapy

Viral Proteases and Antiviral Protease Inhibitor Therapy
  • Author : Uwe Lendeckel,Nigel M. Hooper
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-06-19
  • ISBN : 9789048123483
GET THIS BOOKViral Proteases and Antiviral Protease Inhibitor Therapy

The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most

Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2020-02-03
  • ISBN : 9780128181683
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

Viral Replication Enzymes and their Inhibitors Part A

Viral Replication Enzymes and their Inhibitors Part A
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • ISBN : 9780128234693
GET THIS BOOKViral Replication Enzymes and their Inhibitors Part A

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Encyclopedia of Molecular Pharmacology

Encyclopedia of Molecular Pharmacology
  • Author : Stefan Offermanns,W. Rosenthal
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-08-14
  • ISBN : 9783540389163
GET THIS BOOKEncyclopedia of Molecular Pharmacology

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short

Antiretroviral Resistance in Clinical Practice

Antiretroviral Resistance in Clinical Practice
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2006
  • ISBN : OCLC:1016468897
GET THIS BOOKAntiretroviral Resistance in Clinical Practice

Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors
  • Author : Satya P. Gupta
  • Publisher : Academic Press
  • Release Date : 2017-07-06
  • ISBN : 0128097124
GET THIS BOOKViral Proteases and Their Inhibitors

7.1.17 - Cinanserin Analogs as Promising SARS-CoV 3CLpro Inhibitors

Dengue and Zika: Control and Antiviral Treatment Strategies

Dengue and Zika: Control and Antiviral Treatment Strategies
  • Author : Rolf Hilgenfeld,Subhash G. Vasudevan
  • Publisher : Springer
  • Release Date : 2018-05-29
  • ISBN : 9789811087271
GET THIS BOOKDengue and Zika: Control and Antiviral Treatment Strategies

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing

Aspartic Acid Proteases as Therapeutic Targets

Aspartic Acid Proteases as Therapeutic Targets
  • Author : Arun K. Ghosh
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-04
  • ISBN : 9783527641628
GET THIS BOOKAspartic Acid Proteases as Therapeutic Targets

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and

Proteolytic Enzymes

Proteolytic Enzymes
  • Author : Erwin E. Sterchi,Walter Stöcker
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-11
  • ISBN : 9783642598166
GET THIS BOOKProteolytic Enzymes

Following an overview on proteolytic enzyme assays, this text covers procedures on how to investigate and study proteases. It describes the use of specific restriction proteases as well as inhibitors of proteases to prevent unwanted proteolysis.

Handbook of Antimicrobial Resistance

Handbook of Antimicrobial Resistance
  • Author : Matthias Gotte,Albert Berghuis,Greg Matlashewski,Mark Wainberg,Donald Sheppard
  • Publisher : Springer
  • Release Date : 2018-02-12
  • ISBN : 1493906933
GET THIS BOOKHandbook of Antimicrobial Resistance

While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
  • Author : Jean-Paul Renaud
  • Publisher : John Wiley & Sons
  • Release Date : 2020-01-09
  • ISBN : 9781118900505
GET THIS BOOKStructural Biology in Drug Discovery

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable