Transporters in Drug Discovery and Development

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  • Publisher : Woodhead Publishing
  • Release : 22 August 2014
  • ISBN : 9781908818287
  • Page : 780 pages
  • Rating : 4.5/5 from 103 voters

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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

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Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release Date : 2014-08-22
  • ISBN : 9781908818287
GET THIS BOOKTransporters in Drug Discovery and Development

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery

Transporters in Drug Development

Transporters in Drug Development
  • Author : Yuichi Sugiyama,Bente Steffansen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-09-16
  • ISBN : 9781461482291
GET THIS BOOKTransporters in Drug Development

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges

Drug Transporters

Drug Transporters
  • Author : Guofeng You,Marilyn E. Morris
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-07
  • ISBN : 9781118704981
GET THIS BOOKDrug Transporters

This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-12-31
  • ISBN : 9781782620693
GET THIS BOOKDrug Transporters

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure

Drug Metabolism in Drug Design and Development

Drug Metabolism in Drug Design and Development
  • Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
  • Publisher : John Wiley & Sons
  • Release Date : 2007-11-16
  • ISBN : 0470191686
GET THIS BOOKDrug Metabolism in Drug Design and Development

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed

Drug Transporters

Drug Transporters
  • Author : Martin F. Fromm,Richard B. Kim
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-11-19
  • ISBN : 9783642145414
GET THIS BOOKDrug Transporters

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
  • Author : Qing Yan
  • Publisher : Humana
  • Release Date : 2010-04-26
  • ISBN : STANFORD:36105211741215
GET THIS BOOKMembrane Transporters in Drug Discovery and Development

This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

ADME-Enabling Technologies in Drug Design and Development

ADME-Enabling Technologies in Drug Design and Development
  • Author : Donglu Zhang,Sekhar Surapaneni
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-13
  • ISBN : 9781118180761
GET THIS BOOKADME-Enabling Technologies in Drug Design and Development

A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug Design and Developmentfocuses on the current state of the art in the field, presenting acomprehensive review of the latest tools for generating ADME datain drug discovery. It examines the broadest

Genomics-Driven Healthcare

Genomics-Driven Healthcare
  • Author : Yashwant Pathak
  • Publisher : Springer
  • Release Date : 2018-07-02
  • ISBN : 9789811075063
GET THIS BOOKGenomics-Driven Healthcare

This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology. Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion

Enzyme Inhibition in Drug Discovery and Development

Enzyme Inhibition in Drug Discovery and Development
  • Author : Chuang Lu,Albert P. Li
  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-26
  • ISBN : 0470538945
GET THIS BOOKEnzyme Inhibition in Drug Discovery and Development

The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics,

Drug Transporters Volume 2

Drug Transporters Volume 2
  • Author : Dr Glynis Nicholls ,Dr Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-08-10
  • ISBN : 9781782628668
GET THIS BOOKDrug Transporters Volume 2

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of

Handbook of Drug Metabolism, Third Edition

Handbook of Drug Metabolism, Third Edition
  • Author : Paul G. Pearson,Larry C. Wienkers
  • Publisher : CRC Press
  • Release Date : 2019-05-20
  • ISBN : 9781482262049
GET THIS BOOKHandbook of Drug Metabolism, Third Edition

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016
  • ISBN : 1782628673
GET THIS BOOKDrug Transporters

Oral Bioavailability Assessment

Oral Bioavailability Assessment
  • Author : Ayman F. El-Kattan
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-06
  • ISBN : 9781118916698
GET THIS BOOKOral Bioavailability Assessment

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
  • Author : Albert P. Li
  • Publisher : John Wiley & Sons
  • Release Date : 2021-07-27
  • ISBN : 9781119170846
GET THIS BOOKTransporters and Drug-Metabolizing Enzymes in Drug Toxicity

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug