Translational Systems Biology Concepts and Practice for the Future of Biomedical Research

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  • Publisher : Academic Press
  • Release : 13 November 2017
  • ISBN : 0128101474
  • Page : 178 pages
  • Rating : 4.5/5 from 103 voters

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Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams "

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Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research

Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research
  • Author : Yoram Vodovotz,Gary An
  • Publisher : Academic Press
  • Release Date : 2017-11-13
  • ISBN : 0128101474
GET THIS BOOKTranslational Systems Biology: Concepts and Practice for the Future of Biomedical Research

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine
  • Author : Qing Yan
  • Publisher : Academic Press
  • Release Date : 2017-04-18
  • ISBN : 9780128043882
GET THIS BOOKTranslational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics,

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher : Academic Press
  • Release Date : 2019-09-14
  • ISBN : 9780128137635
GET THIS BOOKTranslational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease

Translational Systems Biology

Translational Systems Biology
  • Author : Yoram Vodovotz,Gary An
  • Publisher : Elsevier
  • Release Date : 2014-10-08
  • ISBN : 9780123978905
GET THIS BOOKTranslational Systems Biology

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the

Handbook of Systems Biology

Handbook of Systems Biology
  • Author : Marian Walhout,Marc Vidal,Job Dekker
  • Publisher : Academic Press
  • Release Date : 2012-12-31
  • ISBN : 9780123859457
GET THIS BOOKHandbook of Systems Biology

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as

Translational Biology in Medicine

Translational Biology in Medicine
  • Author : M. Montano
  • Publisher : Elsevier
  • Release Date : 2014-12-08
  • ISBN : 9781908818652
GET THIS BOOKTranslational Biology in Medicine

The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods

Translational Biotechnology

Translational Biotechnology
  • Author : Yasha Hasija
  • Publisher : Academic Press
  • Release Date : 2021-01-17
  • ISBN : 9780128219737
GET THIS BOOKTranslational Biotechnology

Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This

Encyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology
  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2018-08-21
  • ISBN : 9780128114322
GET THIS BOOKEncyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for

Translational Biomedical Informatics

Translational Biomedical Informatics
  • Author : Bairong Shen,Haixu Tang,Xiaoqian Jiang
  • Publisher : Springer
  • Release Date : 2016-10-31
  • ISBN : 9789811015038
GET THIS BOOKTranslational Biomedical Informatics

This book introduces readers to essential methods and applications in translational biomedical informatics, which include biomedical big data, cloud computing and algorithms for understanding omics data, imaging data, electronic health records and public health data. The storage, retrieval, mining and knowledge discovery of biomedical big data will be among the key challenges for future translational research. The paradigm for precision medicine and healthcare needs to integratively analyze not only the data at the same level – e.g. different omics data

Translational Informatics in Smart Healthcare

Translational Informatics in Smart Healthcare
  • Author : Bairong Shen
  • Publisher : Springer
  • Release Date : 2017-09-15
  • ISBN : 9789811057175
GET THIS BOOKTranslational Informatics in Smart Healthcare

This book is about the transformation of the biomedical information to smart healthcare, the chapters are designed to discuss the health associated factors such as genetics, lifestyle, nutrition and environmental factors. The interactions of these factors and the informatics for the analyses of their effects on health are also covered. The era of aging is approaching and the P4 (predictive, preventive, personalized and participatory) medicine paradigm is becoming practical and reality. According to the Kondratiev's long wave theory, IT (information

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
  • Author : David B. Teplow
  • Publisher : Academic Press
  • Release Date : 2018-10-16
  • ISBN : 9780128162361
GET THIS BOOKProgress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and

Systems Biology of Microbial Infection

Systems Biology of Microbial Infection
  • Author : Reinhard Guthke,Jörg Linde,Marc Thilo Figge,Franziska Mech
  • Publisher : Frontiers E-books
  • Release Date : 2022-09-29
  • ISBN : 9782889190607
GET THIS BOOKSystems Biology of Microbial Infection

The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data

Translational Inflammation

Translational Inflammation
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-24
  • ISBN : 9780128138335
GET THIS BOOKTranslational Inflammation

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes

The Molecular Biology of Arrestins

The Molecular Biology of Arrestins
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2013-06-10
  • ISBN : 9780123947895
GET THIS BOOKThe Molecular Biology of Arrestins

This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field

Cell Biology and Translational Medicine, Volume 12

Cell Biology and Translational Medicine, Volume 12
  • Author : Kursad Turksen
  • Publisher : Springer
  • Release Date : 2021-08-13
  • ISBN : 3030719324
GET THIS BOOKCell Biology and Translational Medicine, Volume 12

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as