Thresholds of Genotoxic Carcinogens

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  • Publisher : Academic Press
  • Release : 01 June 2016
  • ISBN : 0128016639
  • Page : 256 pages
  • Rating : 4.5/5 from 103 voters

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Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

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Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi,Shoji Fukushima
  • Publisher : Academic Press
  • Release Date : 2016-05-20
  • ISBN : 9780128018033
GET THIS BOOKThresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold

Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi,Shoji Fukushima
  • Publisher : Academic Press
  • Release Date : 2016-06-01
  • ISBN : 0128016639
GET THIS BOOKThresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult
  • Author : Helmut Greim,Richard J. Albertini
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012
  • ISBN : 9781849731775
GET THIS BOOKThe Cellular Response to the Genotoxic Insult

This book considers the exposure levels at which genotoxins pose a risk and describes the cellular mechanisms used against them.

Regulatory Toxicology

Regulatory Toxicology
  • Author : Franz-Xaver Reichl,Michael Schwenk
  • Publisher : Springer
  • Release Date : 2014-03-27
  • ISBN : 3642353738
GET THIS BOOKRegulatory Toxicology

This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards,

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test
  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 2020-06-29
  • ISBN : 9789264071247
GET THIS BOOKOECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test

The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...

Cancer Risk Assessment

Cancer Risk Assessment
  • Author : Ching-Hung Hsu,Todd Stedeford
  • Publisher : John Wiley & Sons
  • Release Date : 2010-12-08
  • ISBN : 1118035127
GET THIS BOOKCancer Risk Assessment

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and

Genotoxic Impurities

Genotoxic Impurities
  • Author : Andrew Teasdale
  • Publisher : John Wiley & Sons
  • Release Date : 2011-03-29
  • ISBN : 9780470934753
GET THIS BOOKGenotoxic Impurities

This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and

Mutagenic Impurities

Mutagenic Impurities
  • Author : Andrew Teasdale
  • Publisher : John Wiley & Sons
  • Release Date : 2022-02-15
  • ISBN : 9781119551218
GET THIS BOOKMutagenic Impurities

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers

Science and Decisions

Science and Decisions
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
  • Publisher : National Academies Press
  • Release Date : 2009-03-24
  • ISBN : 9780309120463
GET THIS BOOKScience and Decisions

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult
  • Author : Helmut Greim,Richard Albertini
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-09
  • ISBN : 9781782626046
GET THIS BOOKThe Cellular Response to the Genotoxic Insult

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens,

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release Date : 2001-08-31
  • ISBN : 9781135554200
GET THIS BOOKGenetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard ide

Guidelines for carcinogen risk assessment

Guidelines for carcinogen risk assessment
  • Author : Anonim
  • Publisher : DIANE Publishing
  • Release Date : 2023-02-06
  • ISBN : 9781428904569
GET THIS BOOKGuidelines for carcinogen risk assessment

Encyclopedia of Quantitative Risk Analysis and Assessment

Encyclopedia of Quantitative Risk Analysis and Assessment
  • Author : Anonim
  • Publisher : John Wiley & Sons
  • Release Date : 2008-09-02
  • ISBN : 9780470035498
GET THIS BOOKEncyclopedia of Quantitative Risk Analysis and Assessment

Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety,

Information Resources in Toxicology

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  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • ISBN : 9780128137253
GET THIS BOOKInformation Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

Hayes' Principles and Methods of Toxicology, Sixth Edition

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  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release Date : 2014-10-10
  • ISBN : 9781842145364
GET THIS BOOKHayes' Principles and Methods of Toxicology, Sixth Edition

Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms