Therapeutic Applications of Quadruplex Nucleic Acids

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  • Publisher : Academic Press
  • Release : 19 September 2011
  • ISBN : 9780123751386
  • Page : 210 pages
  • Rating : 4.5/5 from 103 voters

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New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.

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Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release Date : 2011-09-19
  • ISBN : 9780123751386
GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release Date : 2011-08-31
  • ISBN : 9780123751393
GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies.

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids
  • Author : Stephen Neidle,Shankar Balasubramanian
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • ISBN : 9781847555298
GET THIS BOOKQuadruplex Nucleic Acids

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release Date : 2019-08-27
  • ISBN : 9780128197783
GET THIS BOOKNucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-26
  • ISBN : 9780128210185
GET THIS BOOKQuadruplex Nucleic Acids As Targets For Medicinal Chemistry

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

G-Quadruplex Nucleic Acids

G-Quadruplex Nucleic Acids
  • Author : Danzhou Yang,Clement Lin
  • Publisher : Humana
  • Release Date : 2020-09-07
  • ISBN : 1493996681
GET THIS BOOKG-Quadruplex Nucleic Acids

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids
  • Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-10
  • ISBN : 1118092813
GET THIS BOOKMedicinal Chemistry of Nucleic Acids

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids
  • Author : Jonathan B. Chaires,David Graves
  • Publisher : Springer
  • Release Date : 2014-07-08
  • ISBN : 9783642347436
GET THIS BOOKQuadruplex Nucleic Acids

Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and

Electrochemical Immunosensors and Aptasensors

Electrochemical Immunosensors and Aptasensors
  • Author : Paolo Ugo,Ligia M. Moretto
  • Publisher : MDPI
  • Release Date : 2018-03-23
  • ISBN : 9783038424062
GET THIS BOOKElectrochemical Immunosensors and Aptasensors

This book is a printed edition of the Special Issue "Electrochemical Immunosensors and Aptasensors" that was published in Chemosensors

Transcriptome Profiling

Transcriptome Profiling
  • Author : Mohammad Ajmal Ali,Joongku Lee
  • Publisher : Elsevier
  • Release Date : 2022-10-14
  • ISBN : 9780323972314
GET THIS BOOKTranscriptome Profiling

Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis

Protein-Nucleic Acid Interactions

Protein-Nucleic Acid Interactions
  • Author : Phoebe A Rice,Carl C Correll
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008-04-22
  • ISBN : 9781847558268
GET THIS BOOKProtein-Nucleic Acid Interactions

The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the

Catalytically Active Nucleic Acids

Catalytically Active Nucleic Acids
  • Author : Harald Seitz,Frank Stahl,Johanna-Gabriela Walter
  • Publisher : Springer Nature
  • Release Date : 2019-09-30
  • ISBN : 9783030296469
GET THIS BOOKCatalytically Active Nucleic Acids

This volume reviews numerous reaction mechanisms and applications of nucleic acids with catalytic activity. Written by an interdisciplinary team of authors, it provides an essential overview of these acids’ fundamental aspects, while also addressing associated methodologies such as nucleic acid enzyme engineering, peroxidase-mimicking DNAzymes and Aptazymes. After the discovery of natural ribozymes – RNA molecules that mediate the cleavage and formation of phosphodiester bonds and the formation of peptide bonds – numerous artificial ribozymes with altered catalytic activities were produced by in

Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics
  • Author : Marco Filice,Jesús Ruiz-Cabello
  • Publisher : Elsevier
  • Release Date : 2019-02-26
  • ISBN : 9780128144718
GET THIS BOOKNucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book

The Alkali Metal Ions: Their Role for Life

The Alkali Metal Ions: Their Role for Life
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer
  • Release Date : 2016-02-09
  • ISBN : 9783319217567
GET THIS BOOKThe Alkali Metal Ions: Their Role for Life

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements

Application of Computational Techniques in Pharmacy and Medicine

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  • Author : Leonid Gorb,Victor Kuz'min,Eugene Muratov
  • Publisher : Springer
  • Release Date : 2014-11-07
  • ISBN : 9789401792578
GET THIS BOOKApplication of Computational Techniques in Pharmacy and Medicine

The proposed volume provides both fundamental and detailed information about the computational and computational-experimental studies which improve our knowledge of how leaving matter functions, the different properties of drugs (including the calculation and the design of new ones), and the creation of completely new ways of treating numerical diseases. Whenever it is possible, the interplay between theory and experiment is provided. The book features computational techniques such as quantum-chemical and molecular dynamic approaches and quantitative structure–activity relationships. The initial