Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

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  • Publisher : Academic Press
  • Release : 09 February 2019
  • ISBN : 9780128172797
  • Page : 372 pages
  • Rating : 4.5/5 from 103 voters

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
  • Author : Lucia Morbidelli,Benjamin Bonavida
  • Publisher : Academic Press
  • Release Date : 2019-02-09
  • ISBN : 9780128172797
GET THIS BOOKTherapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various

Nitric Oxide (NO) and Cancer

Nitric Oxide (NO) and Cancer
  • Author : Benjamin Bonavida
  • Publisher : Springer
  • Release Date : 2012-09-05
  • ISBN : 1461426111
GET THIS BOOKNitric Oxide (NO) and Cancer

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2022-01-14
  • ISBN : 9780323905565
GET THIS BOOKAntiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
  • Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-08-06
  • ISBN : 9780387464015
GET THIS BOOKThe Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Inflammation in the Pathogenesis of Chronic Diseases

Inflammation in the Pathogenesis of Chronic Diseases
  • Author : Randall E. Harris
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-09
  • ISBN : 9781402056888
GET THIS BOOKInflammation in the Pathogenesis of Chronic Diseases

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Chemokine Biology - Basic Research and Clinical Application

Chemokine Biology - Basic Research and Clinical Application
  • Author : Gordon L. Letts
  • Publisher : Springer Science & Business Media
  • Release Date : 2006
  • ISBN : 376436825X
GET THIS BOOKChemokine Biology - Basic Research and Clinical Application

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set

Nitric Oxide Donors

Nitric Oxide Donors
  • Author : Amedea Seabra
  • Publisher : Academic Press
  • Release Date : 2017-03-17
  • ISBN : 9780128134597
GET THIS BOOKNitric Oxide Donors

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties;

Organic Nitrates

Organic Nitrates
  • Author : P. Needleman
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • ISBN : 9783642660245
GET THIS BOOKOrganic Nitrates

Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use

WHO Guidelines for Indoor Air Quality

WHO Guidelines for Indoor Air Quality
  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release Date : 2010
  • ISBN : UCBK:C105261333
GET THIS BOOKWHO Guidelines for Indoor Air Quality

This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals

The Physiology of Inflammation – The Final Common Pathway to Disease

The Physiology of Inflammation – The Final Common Pathway to Disease
  • Author : Alexandrina Ferreira Mendes,Maria Teresa Cruz,Oreste Gualillo
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-20
  • ISBN : 9782889457298
GET THIS BOOKThe Physiology of Inflammation – The Final Common Pathway to Disease

Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions.

Adhesion Molecules: Function and Inhibition

Adhesion Molecules: Function and Inhibition
  • Author : Klaus Ley
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-08-16
  • ISBN : 9783764379742
GET THIS BOOKAdhesion Molecules: Function and Inhibition

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also

The Hereditary Basis of Rheumatic Diseases

The Hereditary Basis of Rheumatic Diseases
  • Author : Rikard Holmdahl
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-02
  • ISBN : 9783764374198
GET THIS BOOKThe Hereditary Basis of Rheumatic Diseases

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular

Nitric Oxide Synthase

Nitric Oxide Synthase
  • Author : Seyed Soheil Saeedi Saravi
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-05-17
  • ISBN : 9789535131632
GET THIS BOOKNitric Oxide Synthase

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology,

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells

Regulation of Inducible Nitric Oxide Synthase Expression in Human Cells
  • Author : Martin Lee
  • Publisher : Unknown
  • Release Date : 2018
  • ISBN : OCLC:1125747922
GET THIS BOOKRegulation of Inducible Nitric Oxide Synthase Expression in Human Cells

Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses and dysregulated expression of its production by inducible nitric oxide synthase (iNOS) is implicated in the pathogenesis of various inflammatory diseases and cancer. The mechanisms by which the expression of iNOS is regulated in human cells is incompletely understood. I show that NO positively regulates iNOS expression through a positive feedback mechanism that involves S-nitrosylation and activation of the small Ras GTPase, which

Toll-like Receptors in Inflammation

Toll-like Receptors in Inflammation
  • Author : Luke A.J. O'Neill,Elizabeth Brint
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-03-16
  • ISBN : 9783764374419
GET THIS BOOKToll-like Receptors in Inflammation

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There