Therapeutic Antibody Engineering

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  • Publisher : Elsevier
  • Release : 16 October 2012
  • ISBN : 9781908818096
  • Page : 696 pages
  • Rating : 4.5/5 from 103 voters

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The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

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Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • ISBN : 9781908818096
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : W. R. Strohl,Lila M. Strohl
  • Publisher : Woodhead Pub Limited
  • Release Date : 2012
  • ISBN : 1907568379
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • ISBN : 9783527329373
GET THIS BOOKHandbook of Therapeutic Antibodies

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal

Introduction to Antibody Engineering

Introduction to Antibody Engineering
  • Author : Florian Rüker,Gordana Wozniak-Knopp
  • Publisher : Springer Nature
  • Release Date : 2021-01-04
  • ISBN : 9783030546304
GET THIS BOOKIntroduction to Antibody Engineering

This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering”

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-02-21
  • ISBN : 9789535138259
GET THIS BOOKAntibody Engineering

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by

Antibody Engineering

Antibody Engineering
  • Author : Damien Nevoltris,Patrick Chames
  • Publisher : Humana
  • Release Date : 2019-12-10
  • ISBN : 1493993534
GET THIS BOOKAntibody Engineering

This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents,

Antibody Engineering

Antibody Engineering
  • Author : J. Donald Capra
  • Publisher : Karger Publishers
  • Release Date : 1997
  • ISBN : 3805563566
GET THIS BOOKAntibody Engineering

The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and

Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Yuti Chernajovsky,Ahuva Nissim
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-11
  • ISBN : 9783540732594
GET THIS BOOKTherapeutic Antibodies

This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.

Antibody Engineering

Antibody Engineering
  • Author : Benny K. C. Lo
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-03
  • ISBN : 9781592596669
GET THIS BOOKAntibody Engineering

The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to

Protein Therapeutics, 2 Volume Set

Protein Therapeutics, 2 Volume Set
  • Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
  • Publisher : John Wiley & Sons
  • Release Date : 2017-12-04
  • ISBN : 9783527340866
GET THIS BOOKProtein Therapeutics, 2 Volume Set

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then

Antibody Engineering

Antibody Engineering
  • Author : Patrick Chames
  • Publisher : Humana Press
  • Release Date : 2012-08-21
  • ISBN : 1617799734
GET THIS BOOKAntibody Engineering

More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms

Recombinant Antibodies for Immunotherapy

Recombinant Antibodies for Immunotherapy
  • Author : Melvyn Little
  • Publisher : Cambridge University Press
  • Release Date : 2009-07-27
  • ISBN : 9780521887328
GET THIS BOOKRecombinant Antibodies for Immunotherapy

This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.

Monoclonal Antibody Production

Monoclonal Antibody Production
  • Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
  • Publisher : National Academies Press
  • Release Date : 1999-06-06
  • ISBN : 9780309064477
GET THIS BOOKMonoclonal Antibody Production

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The

Antibody Drug Discovery

Antibody Drug Discovery
  • Author : Clive R. Wood
  • Publisher : World Scientific
  • Release Date : 2012
  • ISBN : 9781848166288
GET THIS BOOKAntibody Drug Discovery

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to

Protein Engineering

Protein Engineering
  • Author : Huimin Zhao
  • Publisher : John Wiley & Sons
  • Release Date : 2021-08-23
  • ISBN : 9783527344703
GET THIS BOOKProtein Engineering

A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the