The Synapse

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  • Publisher : Elsevier
  • Release : 16 November 2013
  • ISBN : 9780124186828
  • Page : 512 pages
  • Rating : 4.5/5 from 103 voters

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The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

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The Synapse

The Synapse
  • Author : Virginia M. Pickel,Menahem Segal
  • Publisher : Elsevier
  • Release Date : 2013-11-16
  • ISBN : 9780124186828
GET THIS BOOKThe Synapse

The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights

Simulations of Molecules and Processes in the Synapse

Simulations of Molecules and Processes in the Synapse
  • Author : Kaihsu Tai
  • Publisher : Kaihsu Tai
  • Release Date : 2002
  • ISBN : 9780493909325
GET THIS BOOKSimulations of Molecules and Processes in the Synapse

Structural and Functional Organization of the Synapse

Structural and Functional Organization of the Synapse
  • Author : Johannes W. Hell,Michael D. Ehlers
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-06-25
  • ISBN : 9780387772325
GET THIS BOOKStructural and Functional Organization of the Synapse

This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse’s functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It’s an important text for neuroscientists and disease-oriented clinicians in neurology.

History of the Synapse

History of the Synapse
  • Author : Max R. Bennett
  • Publisher : CRC Press
  • Release Date : 2001-10-11
  • ISBN : 9058231321
GET THIS BOOKHistory of the Synapse

The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a

Folding for the Synapse

Folding for the Synapse
  • Author : Andreas Wyttenbach,Vincent O'Connor
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-22
  • ISBN : 9781441970619
GET THIS BOOKFolding for the Synapse

Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the

Discovering the Brain

Discovering the Brain
  • Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
  • Publisher : National Academies Press
  • Release Date : 1992-01-01
  • ISBN : 9780309045292
GET THIS BOOKDiscovering the Brain

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the

Emotional Modulation of the Synapse

Emotional Modulation of the Synapse
  • Author : Christa McIntyre,Jonathan Eric Ploski
  • Publisher : Frontiers Media SA
  • Release Date : 2015-08-21
  • ISBN : 9782889196067
GET THIS BOOKEmotional Modulation of the Synapse

Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience

History of the Synapse

History of the Synapse
  • Author : Max R. Bennett
  • Publisher : CRC Press
  • Release Date : 2003-09-02
  • ISBN : 9780203302545
GET THIS BOOKHistory of the Synapse

The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a

The Synapse

The Synapse
  • Author : Morgan Sheng,Bernardo Sabatini,Thomas C. Südhof
  • Publisher : Unknown
  • Release Date : 2012
  • ISBN : 1936113023
GET THIS BOOKThe Synapse

"A subject collection from Cold Spring Harbor perspectives in biology"--T.p. verso.

Synaptic Transmission

Synaptic Transmission
  • Author : Stephen D. Meriney,Erika Fanselow
  • Publisher : Academic Press
  • Release Date : 2019-06-12
  • ISBN : 9780128153215
GET THIS BOOKSynaptic Transmission

Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the

The Physiology of Synapses

The Physiology of Synapses
  • Author : John Carew Eccles
  • Publisher : Academic Press
  • Release Date : 2013-10-22
  • ISBN : 9781483226064
GET THIS BOOKThe Physiology of Synapses

The Physiology of Synapses covers the considerable advances in understanding the complex physiology of synapses. This book is divided into 16 chapters that emphasize the mechanism of synaptic transmission. The first chapters describe the structural and physiological features of chemically transmitting synapses. The subsequent chapters deal with the excitatory postsynaptic responses to presynaptic impulse and the release of transmitter by presynaptic impulses. These topics are followed by discussions of the impulse generation by the excitatory postsynaptic potential; the postsynaptic electrical events

Synapses

Synapses
  • Author : W. Maxwell Cowan,William Maxwell Cowan,Thomas C. Südhof,Charles F. Stevens
  • Publisher : JHU Press
  • Release Date : 2003
  • ISBN : 0801871182
GET THIS BOOKSynapses

"For both seasoned neurobiologists and interested newcomers to the field, this book is a worthwhile introduction to the wonders of synapses and the many opportunities for future study that they offer." -- Science

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2011-07-05
  • ISBN : 9780309212243
GET THIS BOOKGlutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting

The Synapse Sequence

The Synapse Sequence
  • Author : Daniel Godfrey
  • Publisher : Titan Books (US, CA)
  • Release Date : 2018-06-19
  • ISBN : 9781785653186
GET THIS BOOKThe Synapse Sequence

The new thrilling sci-fi novel from the author of New Pompeii and Empire of Time In a future London, humans are watched over by AIs and served by bots. But now that justice and jobs are meted out by algorithm, inequality blooms, and protest is brutally silenced. Anna Glover may be the most hated woman in the troubled city - the media's scapegoat for an unpopular war. Now she hides from the public eye, investigating neglected cases by using the

Synapse

Synapse
  • Author : Steven James
  • Publisher : Thomas Nelson
  • Release Date : 2019-10-08
  • ISBN : 9780785225263
GET THIS BOOKSynapse

Thirty years in the future, when AI is so advanced that humans live side by side with cognizant robots called Artificials, Kestrel Hathaway must come to terms not just with what machines know, but with what they believe. Soon after experiencing a personal tragedy, Kestrel witnesses a terrorist attack and is drawn into a world of conspiracies and lies that she and Jordan, her Artificial, have to untangle. With a second, more brutal attack looming on the horizon, their best