The Human Mitochondrial Genome

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  • Publisher : Academic Press
  • Release : 23 July 2020
  • ISBN : 9780128226421
  • Page : 596 pages
  • Rating : 4.5/5 from 103 voters

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The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

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The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-07-23
  • ISBN : 9780128226421
GET THIS BOOKThe Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including

Human Mitochondrial DNA and the Evolution of Homo sapiens

Human Mitochondrial DNA and the Evolution of Homo sapiens
  • Author : Hans-Jürgen Bandelt,Martin Richards,Vincent Macaulay
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-09-05
  • ISBN : 9783540317890
GET THIS BOOKHuman Mitochondrial DNA and the Evolution of Homo sapiens

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. This book takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

The Human Mitochondrial Genome

The Human Mitochondrial Genome
  • Author : Giuseppe Gasparre,Anna Maria Porcelli
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • ISBN : 9780128196564
GET THIS BOOKThe Human Mitochondrial Genome

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including

Mitochondrial DNA

Mitochondrial DNA
  • Author : Herve Seligmann,Ganesh Warthi
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-31
  • ISBN : 9781789842654
GET THIS BOOKMitochondrial DNA

The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization.

The Evolution of Human Mitochondrial DNA

The Evolution of Human Mitochondrial DNA
  • Author : Rebecca Louise Cann
  • Publisher : Unknown
  • Release Date : 1982
  • ISBN : UCAL:C2935263
GET THIS BOOKThe Evolution of Human Mitochondrial DNA

High-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer

High-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer
  • Author : Sneha Grandhi
  • Publisher : Unknown
  • Release Date : 2018
  • ISBN : OCLC:1083218398
GET THIS BOOKHigh-throughput Analysis of the Human Mitochondrial Genome Reveals Its Dynamics, Function, and Signals of Selection in Cancer

Known as the energy powerhouses of the cell, mitochondria carry their own genomes, and encode for key cellular respiration proteins. Carrying multiple copies per cell, a given mitochondrial DNA (mtDNA) variant can be present at varying proportions, termed heteroplasmy. MtDNA is acquired exclusively through maternal inheritance and becomes stochastically replicated and segregated into dividing mitochondria over an organism's lifespan. An individual's constellation of mtDNA variants and their respective heteroplasmy levels can therefore change in response to selective pressures in somatic

Mitochondrial Pathogenesis

Mitochondrial Pathogenesis
  • Author : Hong Kyu Lee,Salvatore DiMauro,Masashi Tanaka,Yau-Huei Wei
  • Publisher : Springer
  • Release Date : 2014-01-10
  • ISBN : 9783662410882
GET THIS BOOKMitochondrial Pathogenesis

Evolution of Life

Evolution of Life
  • Author : Syozo Osawa,Tasuku Honjo
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • ISBN : 9784431683025
GET THIS BOOKEvolution of Life

Nearly thirty million species of organisms are believed to now live on Earth. In addition to accumulating evidence from classical biology, paleontology and earth science, the recent progress of molecular biology has provided new insights into understanding how present-day organisms have evolved with such tremendous diversity. Molecular biological studies show us that all living forms, including E. coli and human beings, derive from a single ancestor that emerged some 4 billion years ago on Earth. This volume aims to discuss the

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer

Investigation of Human Mitochondrial DNA Abnormality in Colon Cancer
  • Author : Mansoureh Akouchekian
  • Publisher : Cuvillier Verlag
  • Release Date : 2008
  • ISBN : 9783867277594
GET THIS BOOKInvestigation of Human Mitochondrial DNA Abnormality in Colon Cancer

The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use

The Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use
  • Author : Elizabeth H. Harris
  • Publisher : Academic Press
  • Release Date : 2009-03-07
  • ISBN : 0080919553
GET THIS BOOKThe Chlamydomonas Sourcebook: Introduction to Chlamydomonas and Its Laboratory Use

Dr. Harris has played a major role in the development of this organism as a model system. Her previous version of the Chlamydomonas Sourcebook which published in 1989, has been a classic in the field and is considered required reading for anyone working with this organism. This latest edition has been expanded to include three volumes providing molecular techniques, analysis of the recently sequenced genome, and reviews of the current status of the diverse fields in which Chlamydomonas is used as

The Role of MGME1 in Maintenance of the Human Mitochondrial Genome

The Role of MGME1 in Maintenance of the Human Mitochondrial Genome
  • Author : Thomas Joseph James Nicholls
  • Publisher : Unknown
  • Release Date : 2014
  • ISBN : OCLC:1063694160
GET THIS BOOKThe Role of MGME1 in Maintenance of the Human Mitochondrial Genome

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : 0815332181
GET THIS BOOKMolecular Biology of the Cell

The Seven Daughters of Eve

The Seven Daughters of Eve
  • Author : Bryan Sykes
  • Publisher : Unknown
  • Release Date : 2002
  • ISBN : 0552148768
GET THIS BOOKThe Seven Daughters of Eve

In 1994 Professor Bryan Sykes, a leading world authority on DNA and human evolution, was called in to examine the frozen remains of a man trapped in glacial ice in northern Italy. News of the discovery of the Ice Man and his age, which was put at over five thousand years old, fascinated the world. But what made the story particularly extraordinary was that Professor Sykes was also able to track down a living generic relative of the Ice Man, a

Normal and Disease-related Sequence Variants of the Human Mitochondrial Genome

Normal and Disease-related Sequence Variants of the Human Mitochondrial Genome
  • Author : Patcharee Lertrit
  • Publisher : Unknown
  • Release Date : 1992
  • ISBN : OCLC:225847117
GET THIS BOOKNormal and Disease-related Sequence Variants of the Human Mitochondrial Genome

Mitochondrial Replacement Techniques

Mitochondrial Replacement Techniques
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases
  • Publisher : National Academies Press
  • Release Date : 2016-03-17
  • ISBN : 9780309388733
GET THIS BOOKMitochondrial Replacement Techniques

Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring),