The Handbook of Metabolic Phenotyping

• Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
• Publisher : Elsevier
• Release Date : 2018-10-04
• ISBN : 9780128122945

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also

• Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
• Publisher : Elsevier
• Release Date : 2011-08-11
• ISBN : 0080468004

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2019-04-02
• ISBN : 9780081019849

The third edition of the Encyclopedia of Analytical Science is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.

• Author : Georgios A. Theodoridis,Helen G. Gika,Ian D. Wilson
• Publisher : Humana
• Release Date : 2019-04-30
• ISBN : 149399252X

This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood

• Author : Ala F. Nassar
• Publisher : John Wiley & Sons
• Release Date : 2009-01-28
• ISBN : 0470439254

A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge

• Author : Valter Tucci
• Publisher : John Wiley & Sons
• Release Date : 2017-03-06
• ISBN : 9781118540718

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a

• Author : Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon
• Publisher : Academic Press
• Release Date : 2016-02-11
• ISBN : 9780128004142

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and

• Author : James E. Barrett,Clive P. Page,Martin C. Michel
• Publisher : Springer Nature
• Release Date : 2019-12-24
• ISBN : 9783030353629

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2020-11-12
• ISBN : 9780128163962

Comprehensive Foodomics offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics

• Author : Wolfram Weckwerth,Guenter Kahl
• Publisher : John Wiley & Sons
• Release Date : 2013-02-28
• ISBN : 9783527669905

This is the newest title in the successful Molecular Plant Biology Handbook Series. Just like the other titles in the series this new book presents an excellent overview of different approaches and techniques in Metabolomics. Contributors are either from ivy-league research institutions or from companies developing new technologies in this dynamic and fast-growing field. With its approach to introduce current techniques in plant metabolomics to a wider audience and with many labs and companies considering to introduce metabolomics for their

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2018-08-21
• ISBN : 9780128114322

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for

• Author : Wesley Doorsamy,Babu Sena Paul,Tshilidzi Marwala
• Publisher : Springer Nature
• Release Date : 2020-07-13
• ISBN : 9783030482305

The book explores technological advances in the fourth industrial revolution (4IR), which is based on a variety of technologies such as artificial intelligence, Internet of Things, machine learning, big data, additive printing, cloud computing, and virtual and augmented reality. Critically analyzing the impacts and effects of these disruptive technologies on various areas, including economics, society, business, government, labor, law, and environment, the book also provides a broad overview of 4IR, with a focus on technologies, to allow readers to gain

• Author : Amit Kumar Rai,Anu Appaiah K. A.
• Publisher : CRC Press
• Release Date : 2021-11-29
• ISBN : 9780429651212

The volume reviews different types of bioactive components associated with food fermentation and their impact on human health. The diversity of microorganism responsible for the production of different types of fermented foods and beverages includes bacteria, yeasts, and fungi. Biotransformation of food constituent by microorganisms occurs during fermentation processes for the production of fermented food and in the gastrointestinal tract by gut microorganisms. This biotransformation results in production of specific bioactive compounds that are responsible for a wide range of

• Author : Paban K. Agrawala,Poonam Rana
• Publisher : Elsevier
• Release Date : 2021-08-25
• ISBN : 9780323856539

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer,

• Author : Julia Kuligowski,Guillermo Quintás
• Publisher : MDPI
• Release Date : 2021-04-07
• ISBN : 9783039438136

Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field