The Epigenetics of Autoimmunity

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  • Publisher : Academic Press
  • Release : 25 April 2018
  • ISBN : 9780128099285
  • Page : 432 pages
  • Rating : 4.5/5 from 103 voters

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The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

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The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity
  • Author : Rongxin Zhang
  • Publisher : Academic Press
  • Release Date : 2018-04-25
  • ISBN : 9780128099285
GET THIS BOOKThe Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to

The Epigenetics of Autoimmune Diseases

The Epigenetics of Autoimmune Diseases
  • Author : Moncef Zouali
  • Publisher : John Wiley & Sons
  • Release Date : 2009-04-01
  • ISBN : 0470743565
GET THIS BOOKThe Epigenetics of Autoimmune Diseases

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
  • Author : Christopher Chang,Qianjin Lu
  • Publisher : Springer Nature
  • Release Date : 2020-05-22
  • ISBN : 9789811534492
GET THIS BOOKEpigenetics in Allergy and Autoimmunity

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover

Epigenetics of the Immune System

Epigenetics of the Immune System
  • Author : Dieter Kabelitz,Jaydeep Bhat
  • Publisher : Academic Press
  • Release Date : 2020-06-04
  • ISBN : 9780128179659
GET THIS BOOKEpigenetics of the Immune System

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release Date : 2019-03-25
  • ISBN : 9783527343140
GET THIS BOOKEpigenetic Drug Discovery

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and

Epigenetics in Human Disease

Epigenetics in Human Disease
  • Author : Trygve O. Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2012
  • ISBN : 9780123884152
GET THIS BOOKEpigenetics in Human Disease

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable,

Mosaic of Autoimmunity

Mosaic of Autoimmunity
  • Author : Carlo Perricone,Yehuda Shoenfeld
  • Publisher : Academic Press
  • Release Date : 2019-02-15
  • ISBN : 9780128143070
GET THIS BOOKMosaic of Autoimmunity

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers

Epigenetics and Dermatology

Epigenetics and Dermatology
  • Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
  • Publisher : Academic Press
  • Release Date : 2015-02-16
  • ISBN : 9780128012727
GET THIS BOOKEpigenetics and Dermatology

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities

Prognostic Epigenetics

Prognostic Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-11-01
  • ISBN : 9780128142608
GET THIS BOOKPrognostic Epigenetics

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-02-06
  • ISBN : 9780128145142
GET THIS BOOKComputational Epigenetics and Diseases

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease,

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release Date : 2015-08-11
  • ISBN : 9780127999203
GET THIS BOOKDNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Translational Studies on Inflammation

Translational Studies on Inflammation
  • Author : Ane C.F. Nunes
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-01-08
  • ISBN : 9781789843576
GET THIS BOOKTranslational Studies on Inflammation

Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
  • Author : Shuai Li,John Hopper
  • Publisher : Academic Press
  • Release Date : 2021-08-31
  • ISBN : 9780128209523
GET THIS BOOKTwin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic

The Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity
  • Author : Denise Faustman
  • Publisher : Academic Press
  • Release Date : 2014-03-13
  • ISBN : 9780128004616
GET THIS BOOKThe Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science

Personalized Epigenetics

Personalized Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2015-04-28
  • ISBN : 9780128004364
GET THIS BOOKPersonalized Epigenetics

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology