RNA Based Regulation in Human Health and Disease

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  • Publisher : Academic Press
  • Release : 19 August 2020
  • ISBN : 9780128171943
  • Page : 444 pages
  • Rating : 4.5/5 from 103 voters

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RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

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RNA-Based Regulation in Human Health and Disease

RNA-Based Regulation in Human Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • ISBN : 9780128171943
GET THIS BOOKRNA-Based Regulation in Human Health and Disease

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA

microRNA Regulation in Health and Disease

microRNA Regulation in Health and Disease
  • Author : Clifford J. Steer,Subbaya Subramanian
  • Publisher : MDPI
  • Release Date : 2020-02-21
  • ISBN : 9783039217144
GET THIS BOOKmicroRNA Regulation in Health and Disease

MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA

Epigenetics and Reproductive Health

Epigenetics and Reproductive Health
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-09-12
  • ISBN : 9780128197547
GET THIS BOOKEpigenetics and Reproductive Health

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted

Epigenetics of the Immune System

Epigenetics of the Immune System
  • Author : Dieter Kabelitz,Jaydeep Bhat
  • Publisher : Academic Press
  • Release Date : 2020-06-04
  • ISBN : 9780128179659
GET THIS BOOKEpigenetics of the Immune System

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune

Epigenetics Methods

Epigenetics Methods
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2020-07-08
  • ISBN : 9780128194157
GET THIS BOOKEpigenetics Methods

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used

microRNA Regulation in Health and Disease

microRNA Regulation in Health and Disease
  • Author : Clifford Steer,Subree Subramanian
  • Publisher : Unknown
  • Release Date : 2020
  • ISBN : 3039217151
GET THIS BOOKmicroRNA Regulation in Health and Disease

MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : 0815332181
GET THIS BOOKMolecular Biology of the Cell

RNA Diseases in Humans – From Fundamental Research to Therapeutic Applications

RNA Diseases in Humans – From Fundamental Research to Therapeutic Applications
  • Author : Naoyuki Kataoka,Akila Mayeda,Kinji Ohno
  • Publisher : Frontiers Media SA
  • Release Date : 2019-10-15
  • ISBN : 9782889630974
GET THIS BOOKRNA Diseases in Humans – From Fundamental Research to Therapeutic Applications

This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Release Date : 2015-10-10
  • ISBN : 9780128016725
GET THIS BOOKThe Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological

Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases

Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases
  • Author : Shaveta Kanoria,Santosh Kumar,Florent Hubé
  • Publisher : Frontiers Media SA
  • Release Date : 2022-05-27
  • ISBN : 9782889762484
GET THIS BOOKNon-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases

Human Epigenomics

Human Epigenomics
  • Author : Carsten Carlberg,Ferdinand Molnár
  • Publisher : Springer
  • Release Date : 2018-02-01
  • ISBN : 9789811076145
GET THIS BOOKHuman Epigenomics

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the

Molecular Biology of Long Non-coding RNAs

Molecular Biology of Long Non-coding RNAs
  • Author : Ahmad M. Khalil
  • Publisher : Springer
  • Release Date : 2019-06-06
  • ISBN : 9783030170868
GET THIS BOOKMolecular Biology of Long Non-coding RNAs

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs,

Engineering Synthetic Ligand-responsive RNA Devices for Controlling the Cell Cycle

Engineering Synthetic Ligand-responsive RNA Devices for Controlling the Cell Cycle
  • Author : Kathy Yufeng Wei
  • Publisher : Unknown
  • Release Date : 2015
  • ISBN : OCLC:919018522
GET THIS BOOKEngineering Synthetic Ligand-responsive RNA Devices for Controlling the Cell Cycle

Synthetic biology aims to program cells by applying engineering principles to the design of genetic circuits to control and monitor cellular behavior. Programmed cells can harness existing dynamically coordinated biologically processes to rescue cellular malfunctions, control existing cellular morphology, and introduce useful novel functionality. Recent advances in the field are leading to genetic circuits of higher-order complexity in mammalian cells, which may ultimately be used to study and reprogram phenotypes that play a key role in human health and disease,

Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease

Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease
  • Author : Asim K. Duttaroy
  • Publisher : Academic Press
  • Release Date : 2021-07-08
  • ISBN : 9780128221945
GET THIS BOOKEvidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease

Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease explores a wide range of studies from clinical investigations to mechanistic research, covering the actions of bioactives on specific tissues and cells in intestinal, neurological, immunological and cardiovascular health and disease, including cancers. The book also focuses on metabolism, mechanisms of actions, tissue-specific effects, and the structure–function relationships between clinical trial, ex vivo and in vitro data. Written for nutrition researchers, clinical researchers, dieticians, and others

RNA and DNA Diagnostics

RNA and DNA Diagnostics
  • Author : Volker A. Erdmann,Stefan Jurga,Jan Barciszewski
  • Publisher : Springer
  • Release Date : 2015-06-10
  • ISBN : 9783319173054
GET THIS BOOKRNA and DNA Diagnostics

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific