Research in the Biomedical Sciences

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  • Publisher : Academic Press
  • Release : 01 June 2017
  • ISBN : 0128047259
  • Page : 356 pages
  • Rating : 4.5/5 from 103 voters

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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a "big picture" perspective that includes the scope of the replicability issue and covers initiatives that have the potential to act as effective solutions Offers real world research context for transparent, replicable experimental design and execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

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Research in the Biomedical Sciences

Research in the Biomedical Sciences
  • Author : Michael Curtis,Michael Williams
  • Publisher : Academic Press
  • Release Date : 2017-06-01
  • ISBN : 0128047259
GET THIS BOOKResearch in the Biomedical Sciences

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility

Reproducibility and Replicability in Science

Reproducibility and Replicability in Science
  • Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
  • Publisher : National Academies Press
  • Release Date : 2019-10-20
  • ISBN : 9780309486163
GET THIS BOOKReproducibility and Replicability in Science

One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release Date : 2020-04-28
  • ISBN : 9780309664066
GET THIS BOOKEnhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release Date : 2020-05-28
  • ISBN : 9780309663496
GET THIS BOOKEnhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research
  • Author : Erwin B. Montgomery
  • Publisher : Academic Press
  • Release Date : 2019-03-14
  • ISBN : 9780128176726
GET THIS BOOKReproducibility in Biomedical Research

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of

Implementing Reproducible Research

Implementing Reproducible Research
  • Author : Victoria Stodden,Friedrich Leisch,Roger D. Peng
  • Publisher : CRC Press
  • Release Date : 2014-04-14
  • ISBN : 9781466561595
GET THIS BOOKImplementing Reproducible Research

In computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be available for widely distributing the data and code. In addition, both data and code need to be licensed permissively enough so that others can reproduce the work without a substantial

Rigor Mortis

Rigor Mortis
  • Author : Richard Harris
  • Publisher : Basic Books
  • Release Date : 2018-05-01
  • ISBN : 154164414X
GET THIS BOOKRigor Mortis

"A rewarding read for anyone who wants to know the unvarnished truth about how science really gets done."--Financial Times American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal

Experimental Design for Laboratory Biologists

Experimental Design for Laboratory Biologists
  • Author : Stanley E. Lazic
  • Publisher : Cambridge University Press
  • Release Date : 2016-10-31
  • ISBN : 9781107074293
GET THIS BOOKExperimental Design for Laboratory Biologists

A guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results.

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Good Research Practice in Non-Clinical Pharmacology and Biomedicine
  • Author : Anton Bespalov,Martin C. Michel,Thomas Steckler
  • Publisher : Springer Nature
  • Release Date : 2020-01-01
  • ISBN : 9783030336561
GET THIS BOOKGood Research Practice in Non-Clinical Pharmacology and Biomedicine

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Fostering Integrity in Research

Fostering Integrity in Research
  • Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science
  • Publisher : National Academies Press
  • Release Date : 2018-01-13
  • ISBN : 9780309391252
GET THIS BOOKFostering Integrity in Research

The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science:

The Practice of Reproducible Research

The Practice of Reproducible Research
  • Author : Justin Kitzes,Daniel Turek,Fatma Deniz
  • Publisher : Univ of California Press
  • Release Date : 2017-10-17
  • ISBN : 9780520294752
GET THIS BOOKThe Practice of Reproducible Research

The Practice of Reproducible Research presents concrete examples of how researchers in the data-intensive sciences are working to improve the reproducibility of their research projects. In each of the thirty-one case studies in this volume, the author or team describes the workflow that they used to complete a real-world research project. Authors highlight how they utilized particular tools, ideas, and practices to support reproducibility, emphasizing the very practical how, rather than the why or what, of conducting reproducible research. Part 1

Towards Bayesian Model-Based Demography

Towards Bayesian Model-Based Demography
  • Author : Jakub Bijak
  • Publisher : Springer Nature
  • Release Date : 2022-06-27
  • ISBN : 9783030830397
GET THIS BOOKTowards Bayesian Model-Based Demography

Experimental Design and Reproducibility in Preclinical Animal Studies

Experimental Design and Reproducibility in Preclinical Animal Studies
  • Author : José M. Sánchez Morgado,Aurora Brønstad
  • Publisher : Springer
  • Release Date : 2021-09-01
  • ISBN : 3030661466
GET THIS BOOKExperimental Design and Reproducibility in Preclinical Animal Studies

This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.

Metabolomics for Biomedical Research

Metabolomics for Biomedical Research
  • Author : Jerzy Adamski
  • Publisher : Academic Press
  • Release Date : 2020-03-20
  • ISBN : 9780128127858
GET THIS BOOKMetabolomics for Biomedical Research

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells

Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results

Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on Applied and Theoretical Statistics
  • Publisher : National Academies Press
  • Release Date : 2016-03-29
  • ISBN : 9780309392020
GET THIS BOOKStatistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results

Questions about the reproducibility of scientific research have been raised in numerous settings and have gained visibility through several high-profile journal and popular press articles. Quantitative issues contributing to reproducibility challenges have been considered (including improper data measurement and analysis, inadequate statistical expertise, and incomplete data, among others), but there is no clear consensus on how best to approach or to minimize these problems. A lack of reproducibility of scientific results has created some distrust in scientific findings among the