Redox Signaling and Biomarkers in Ageing

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  • Publisher : Springer Nature
  • Release : 08 January 2022
  • ISBN : 9783030849658
  • Page : 439 pages
  • Rating : 4.5/5 from 103 voters

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This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

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Redox Signaling and Biomarkers in Ageing

Redox Signaling and Biomarkers in Ageing
  • Author : Ufuk Çakatay
  • Publisher : Springer Nature
  • Release Date : 2022-01-08
  • ISBN : 9783030849658
GET THIS BOOKRedox Signaling and Biomarkers in Ageing

This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences

Human Aging

Human Aging
  • Author : Calogero Caruso,Giuseppina Candore
  • Publisher : Academic Press
  • Release Date : 2021-05-11
  • ISBN : 9780128227374
GET THIS BOOKHuman Aging

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and

Oxidative Stress and Antioxidant Protection

Oxidative Stress and Antioxidant Protection
  • Author : Donald Armstrong,Robert D. Stratton
  • Publisher : John Wiley & Sons
  • Release Date : 2016-01-14
  • ISBN : 9781118832400
GET THIS BOOKOxidative Stress and Antioxidant Protection

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior

Reviews on Biomarker Studies in Aging and Anti-Aging Research

Reviews on Biomarker Studies in Aging and Anti-Aging Research
  • Author : Paul C. Guest
  • Publisher : Springer Nature
  • Release Date : 2019-09-06
  • ISBN : 9783030256500
GET THIS BOOKReviews on Biomarker Studies in Aging and Anti-Aging Research

Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as

Oxidative Stress Mechanisms and their Modulation

Oxidative Stress Mechanisms and their Modulation
  • Author : Mohinder Bansal,Naveen Kaushal
  • Publisher : Springer
  • Release Date : 2014-10-17
  • ISBN : 9788132220329
GET THIS BOOKOxidative Stress Mechanisms and their Modulation

Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
  • Author : Marco Malavolta,Eugenio Mocchegiani
  • Publisher : Academic Press
  • Release Date : 2016-04-15
  • ISBN : 9780128018279
GET THIS BOOKMolecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and

General Methods in Biomarker Research and their Applications

General Methods in Biomarker Research and their Applications
  • Author : Victor R. Preedy,Vinood B. Patel
  • Publisher : Springer
  • Release Date : 2015-08-14
  • ISBN : 9400776950
GET THIS BOOKGeneral Methods in Biomarker Research and their Applications

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of

Biomarkers of Human Aging

Biomarkers of Human Aging
  • Author : Alexey Moskalev
  • Publisher : Springer Nature
  • Release Date : 2019-09-13
  • ISBN : 9783030249700
GET THIS BOOKBiomarkers of Human Aging

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts

Explaining Health Across the Sciences

Explaining Health Across the Sciences
  • Author : Jonathan Sholl,Suresh I.S. Rattan
  • Publisher : Springer Nature
  • Release Date : 2020-08-28
  • ISBN : 9783030526634
GET THIS BOOKExplaining Health Across the Sciences

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific

Advances in Mitochondrial Medicine

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  • Author : Roberto Scatena,Patrizia Bottoni,Bruno Giardina
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-03-08
  • ISBN : 9789400728691
GET THIS BOOKAdvances in Mitochondrial Medicine

Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include

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  • Author : Suresh I. S. Rattan,Gurcharan Kaur
  • Publisher : Springer Nature
  • Release Date : 2021-11-04
  • ISBN : 9783030830175
GET THIS BOOKNutrition, Food and Diet in Ageing and Longevity

This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal

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Free Radicals and Diseases
  • Author : Rizwan Ahmad
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-10-26
  • ISBN : 9789535127468
GET THIS BOOKFree Radicals and Diseases

The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Biomarker

Biomarker
  • Author : Ghousia Begum
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-09-05
  • ISBN : 9781789236668
GET THIS BOOKBiomarker

This book investigates the emerging use of biomarkers as a diagnostic tool for the identification of patients with an abnormal condition or as a tool for staging the extent of disease, as an indicator of disease prognosis. Chapters in Part I focus on biomarkers for cancer, including breast cancer and pancreatic cancer, as well as circulating microRNA profiling in cancer biomarker discovery. Chapters in Part II focus on biomarkers of other diagnoses/diseases, including sepsis, childhood renal diseases, pulmonary diseases,

Brain Aging

Brain Aging
  • Author : David R. Riddle
  • Publisher : CRC Press
  • Release Date : 2007-04-19
  • ISBN : 1420005529
GET THIS BOOKBrain Aging

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

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  • Author : Irfan Rahman,Debasis Bagchi
  • Publisher : Academic Press
  • Release Date : 2013-09-03
  • ISBN : 9780123978073
GET THIS BOOKInflammation, Advancing Age and Nutrition

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes