Drug Discovery for Psychiatric Disorders

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  • Publisher : Royal Society of Chemistry
  • Release : 08 October 2012
  • ISBN : 9781849734943
  • Page : 678 pages
  • Rating : 4.5/5 from 103 voters

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The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments. For example, currently available treatments for schizophrenia address mainly the positive symptoms and largely neglect the negative symptoms and cognitive disfunction which greatly impact overall morbidity. Similarly, whilst the current first line antidepressants show significantly improved side effect profiles compared to the first generation therapies, there still up to 40% of patients who are treatment resistant, and even in the patient population which responds well, the onset of action is slow at typically 2-3 weeks. The aim of this book is to provide the first point of call for those involved or just interested in this rapidly expanding and increasingly fragmented field of research and drug discovery. The editors will combine their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders in this field to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders, such as schizophrenia, depression, anxiety, ADHD, bipolar disorder, addiction and autism.

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Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
  • Author : Zoran Rankovic,Richard Hargreaves,Matilda Bingham
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-10-08
  • ISBN : 9781849734943
GET THIS BOOKDrug Discovery for Psychiatric Disorders

The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments.

Modern CNS Drug Discovery

Modern CNS Drug Discovery
  • Author : Rudy Schreiber
  • Publisher : Springer Nature
  • Release Date : 2021-06-17
  • ISBN : 9783030623517
GET THIS BOOKModern CNS Drug Discovery

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release Date : 2008-11-18
  • ISBN : 0080920381
GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery: Neurological Disorders

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical

Drug Discovery for Schizophrenia

Drug Discovery for Schizophrenia
  • Author : Tatiana V. Lipina,John C. Roder
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-05-13
  • ISBN : 9781782620266
GET THIS BOOKDrug Discovery for Schizophrenia

Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing

Psychiatric Drug Discovery and Development

Psychiatric Drug Discovery and Development
  • Author : Strategic Research Institute
  • Publisher : Unknown
  • Release Date : 2003
  • ISBN : OCLC:84520532
GET THIS BOOKPsychiatric Drug Discovery and Development

Epigenetics in Psychiatry

Epigenetics in Psychiatry
  • Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
  • Publisher : Academic Press
  • Release Date : 2021-08-16
  • ISBN : 9780128235782
GET THIS BOOKEpigenetics in Psychiatry

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent

The Myth of the Chemical Cure

The Myth of the Chemical Cure
  • Author : J. Moncrieff
  • Publisher : Springer
  • Release Date : 2016-04-13
  • ISBN : 9780230589445
GET THIS BOOKThe Myth of the Chemical Cure

This book overturns the idea that psychiatric drugs work by correcting chemical imbalance and analyzes the professional, commercial and political vested interests that have shaped this view. It provides a comprehensive critique of research on drugs including antidepressants, antipsychotics and mood stabilizers.

Clinical Pharmacology in Psychiatry

Clinical Pharmacology in Psychiatry
  • Author : Lars F. Gram,Luc P. Balant,Herbert Y. Meltzer,Svein G. Dahl
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-07
  • ISBN : 9783642780103
GET THIS BOOKClinical Pharmacology in Psychiatry

This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basic theme of the previous meetings in this series (Chicago 1979, Troms0 1980, Odense 1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge the gap between experimental development and clinical reality in psychopharmacology. After more than 25 years of intensive research in biological psychiatry, basic understanding

Lithium: A Doctor, a Drug, and a Breakthrough

Lithium: A Doctor, a Drug, and a Breakthrough
  • Author : Walter A. Brown
  • Publisher : Liveright Publishing
  • Release Date : 2019-08-13
  • ISBN : 9781631492006
GET THIS BOOKLithium: A Doctor, a Drug, and a Breakthrough

The remarkable untold story of a miracle drug, the forgotten pioneer who discovered it, and the fight to bring lithium to the masses. The DNA double helix, penicillin, the X-ray, insulin—these are routinely cited as some of the most important medical discoveries of the twentieth century. And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
  • Author : Jens-Uwe Peters
  • Publisher : John Wiley & Sons
  • Release Date : 2012-03-13
  • ISBN : 9780470590904
GET THIS BOOKPolypharmacology in Drug Discovery

"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release Date : 2008-11-17
  • ISBN : 9780080920399
GET THIS BOOKAnimal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • ISBN : 9780309292498
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
  • Author : Zoran Rankovic,Richard Hargreaves,Matilda Bingham
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012
  • ISBN : 9781849733656
GET THIS BOOKDrug Discovery for Psychiatric Disorders

This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.

Accelerating the Development of Biomarkers for Drug Safety

Accelerating the Development of Biomarkers for Drug Safety
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release Date : 2009-07-20
  • ISBN : 0309142318
GET THIS BOOKAccelerating the Development of Biomarkers for Drug Safety

Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for

Anatomy of an Epidemic

Anatomy of an Epidemic
  • Author : Robert Whitaker
  • Publisher : Crown
  • Release Date : 2010-04-13
  • ISBN : 9780307452436
GET THIS BOOKAnatomy of an Epidemic

Updated with bonus material, including a new foreword and afterword with new research, this New York Times bestseller is essential reading for a time when mental health is constantly in the news. In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Interwoven with Whitaker’s groundbreaking analysis of the merits of psychiatric medications are