Polycomb Group Proteins

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  • Publisher : Academic Press
  • Release : 01 January 2017
  • ISBN : 9780128098226
  • Page : 372 pages
  • Rating : 4.5/5 from 103 voters

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Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome

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Polycomb Group Proteins

Polycomb Group Proteins
  • Author : Vincenzo Pirrotta
  • Publisher : Academic Press
  • Release Date : 2017-01-01
  • ISBN : 9780128098226
GET THIS BOOKPolycomb Group Proteins

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
  • Author : Suming Huang,Michael D Litt,C. Ann Blakey
  • Publisher : Academic Press
  • Release Date : 2015-10-19
  • ISBN : 9780128004715
GET THIS BOOKEpigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease
  • Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
  • Publisher : Springer
  • Release Date : 2016-06-24
  • ISBN : 9784431546283
GET THIS BOOKEtiology and Morphogenesis of Congenital Heart Disease

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide

Introduction to Epigenetics

Introduction to Epigenetics
  • Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
  • Publisher : Springer Nature
  • Release Date : 2021-03-23
  • ISBN : 9783030686703
GET THIS BOOKIntroduction to Epigenetics

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading

Nuclear Architecture and Dynamics

Nuclear Architecture and Dynamics
  • Author : Christophe Lavelle,Jean-Marc Victor
  • Publisher : Academic Press
  • Release Date : 2017-10-27
  • ISBN : 9780128035030
GET THIS BOOKNuclear Architecture and Dynamics

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists,

Polycomb Group Proteins

Polycomb Group Proteins
  • Author : Chiara Lanzuolo,Beatrice Bodega
  • Publisher : Humana Press
  • Release Date : 2016-09-14
  • ISBN : 1493963783
GET THIS BOOKPolycomb Group Proteins

This volume presents the most recent technologies used in the Polycomb Group Proteins (PcG) field. Chapters detail state-of-the-art methods, creating a unique and comprehensive reference source for investigating Polycomb function in the nucleus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Polycomb Group Proteins: Method and Protocols

Handbook of Epigenetics

Handbook of Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release Date : 2017-07-10
  • ISBN : 9780128054772
GET THIS BOOKHandbook of Epigenetics

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue

Polycomb Group Proteins in the Freshwater Polyp Hydra

Polycomb Group Proteins in the Freshwater Polyp Hydra
  • Author : Sonja Matt
  • Publisher : Unknown
  • Release Date : 2011
  • ISBN : OCLC:749957281
GET THIS BOOKPolycomb Group Proteins in the Freshwater Polyp Hydra

Epigenetics

Epigenetics
  • Author : C. David Allis,Thomas Jenuwein,Danny Reinberg,Marie-Laure Caparros
  • Publisher : CSHL Press
  • Release Date : 2007
  • ISBN : 9780879697242
GET THIS BOOKEpigenetics

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and

The Myelodysplastic Syndromes

The Myelodysplastic Syndromes
  • Author : Judit Várkonyi
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-03-23
  • ISBN : 9789400704404
GET THIS BOOKThe Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. The major morbidity relates to patients’ symptomatic cytopenias.MDS was previously named as “preleukemia “ or “ smoldering leukemia” as the lack of terminal cells in MDS and because about 25% of all cases progresses into acute myeloid leukemia. According to various reports the annual incidence of MDS ranges widely from 2-12 per 100.000, increasing to 30-50 cases per 100.000 among persons aged 70 or older. It is believed that the true

Computational Genomics with R

Computational Genomics with R
  • Author : Altuna Akalin
  • Publisher : CRC Press
  • Release Date : 2020-12-16
  • ISBN : 9781498781862
GET THIS BOOKComputational Genomics with R

Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the

CtBP Family Proteins

CtBP Family Proteins
  • Author : G. Chinnadurai
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-05-07
  • ISBN : 9780387399737
GET THIS BOOKCtBP Family Proteins

The Ctbp family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. This book is a comprehensive monograph on the Ctbp family proteins.

Polycomb Group Proteins and Homeotic Gene Silencing in Drosophila

Polycomb Group Proteins and Homeotic Gene Silencing in Drosophila
  • Author : Aditya Kumar Sengupta
  • Publisher : Unknown
  • Release Date : 2003
  • ISBN : 3898255735
GET THIS BOOKPolycomb Group Proteins and Homeotic Gene Silencing in Drosophila

Epigenetics and Chromatin

Epigenetics and Chromatin
  • Author : Philippe Jeanteur
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-09-10
  • ISBN : 3540852360
GET THIS BOOKEpigenetics and Chromatin

Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express

Epigenetic Regulation of Skin Development and Regeneration

Epigenetic Regulation of Skin Development and Regeneration
  • Author : Vladimir A. Botchkarev,Sarah E. Millar
  • Publisher : Springer
  • Release Date : 2018-09-03
  • ISBN : 9783319167695
GET THIS BOOKEpigenetic Regulation of Skin Development and Regeneration

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration