Piperidine Based Drug Discovery

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Read or download book entitled Piperidine Based Drug Discovery written by Ruben Vardanyan and published by Elsevier in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that Piperidine Based Drug Discovery book is available in the library.

  • Publisher : Elsevier
  • Release : 12 June 2017
  • ISBN : 9780128134283
  • Page : 358 pages
  • Rating : 4.5/5 from 103 voters

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Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

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Piperidine-Based Drug Discovery

Piperidine-Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release Date : 2017-06-12
  • ISBN : 9780128134283
GET THIS BOOKPiperidine-Based Drug Discovery

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks
  • Author : Jie Jack Li,Minmin Yang
  • Publisher : CRC Press
  • Release Date : 2021-10-21
  • ISBN : 9781000416015
GET THIS BOOKDrug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel

Small molecule scaffold synthesis, one-bead one-compound library synthesis, and method development in drug discovery

Small molecule scaffold synthesis, one-bead one-compound library synthesis, and method development in drug discovery
  • Author : Seth M. Dixon
  • Publisher : Unknown
  • Release Date : 2006
  • ISBN : UCAL:X74600
GET THIS BOOKSmall molecule scaffold synthesis, one-bead one-compound library synthesis, and method development in drug discovery

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-07-15
  • ISBN : 9781782627913
GET THIS BOOKSynthetic Methods in Drug Discovery

Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • ISBN : 9781118686355
GET THIS BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Fragment-based Drug Discovery

Fragment-based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • ISBN : 9783527337750
GET THIS BOOKFragment-based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Fragment-Based Drug Discovery

Fragment-Based Drug Discovery
  • Author : Steven Howard,Chris Abell
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-07-03
  • ISBN : 9781849739085
GET THIS BOOKFragment-Based Drug Discovery

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug

Structure-based Design of Drugs and Other Bioactive Molecules

Structure-based Design of Drugs and Other Bioactive Molecules
  • Author : Arun K. Ghosh,Sandra Gemma
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • ISBN : 9783527333653
GET THIS BOOKStructure-based Design of Drugs and Other Bioactive Molecules

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use

Peptide-based Drug Discovery

Peptide-based Drug Discovery
  • Author : Ved Srivastava
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-06-22
  • ISBN : 9781788011716
GET THIS BOOKPeptide-based Drug Discovery

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
  • Author : Robert Stroud,Janet Finer-Moore
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • ISBN : 9781847557964
GET THIS BOOKComputational and Structural Approaches to Drug Discovery

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This

High-Throughput Lead Optimization in Drug Discovery

High-Throughput Lead Optimization in Drug Discovery
  • Author : Tushar Kshirsagar
  • Publisher : CRC Press
  • Release Date : 2008-03-04
  • ISBN : 9781420006964
GET THIS BOOKHigh-Throughput Lead Optimization in Drug Discovery

A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit

Lead Generation Using a Privileged Structure-based Approach

Lead Generation Using a Privileged Structure-based Approach
  • Author : Sivakumar Annadurai
  • Publisher : Unknown
  • Release Date : 2011
  • ISBN : OCLC:1280138105
GET THIS BOOKLead Generation Using a Privileged Structure-based Approach

In drug discovery there are several approaches to lead generation and one traditional approach involves the synthesis and screening of a structurally diverse compound library against a number of biological targets to identify high affinity lead compounds. The use of a `privileged' structure-based compound library represents a viable approach that could lead to drug like lead compounds. Privileged structures are defined as those ligand substructures that may be used to generate high affinity leads for more than one type of

Peptidomimetics in Organic and Medicinal Chemistry

Peptidomimetics in Organic and Medicinal Chemistry
  • Author : Antonio Guarna,Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release Date : 2014-03-14
  • ISBN : 9781118683149
GET THIS BOOKPeptidomimetics in Organic and Medicinal Chemistry

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres,

Structure-Based Drug Design

Structure-Based Drug Design
  • Author : Pandi Veerapandian
  • Publisher : Routledge
  • Release Date : 2018-03-29
  • ISBN : 9781351413060
GET THIS BOOKStructure-Based Drug Design

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase

Bioactive Peptides in Drug Discovery and Design

Bioactive Peptides in Drug Discovery and Design
  • Author : John Matsoukas,Thomas Mavromoustakos
  • Publisher : IOS Press
  • Release Date : 1999
  • ISBN : 9051994257
GET THIS BOOKBioactive Peptides in Drug Discovery and Design

As in previous editions, the focus in ESSENTIAL MATHEMATICS with APPLICATIONS remains on the Aufmann Interactive Method (AIM). Students are encouraged to be active participants in the classroom and in their own studies as they work through the How To examples and the paired Examples and You Try It problems. Student engagement is crucial to success. Presenting students with worked examples, and then providing them with the opportunity to immediately solve similar problems, helps them build their confidence and eventually