Piperidine Based Drug Discovery

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  • Publisher : Heterocyclic Drug Discovery
  • Release : 14 June 2017
  • ISBN : 0128051574
  • Page : 358 pages
  • Rating : 4.5/5 from 103 voters

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10.22 Piperidine-Based Gastric Antisecretory Drugs -- 10.23 Piperidine-Based Hypoglycemic Drugs -- 10.24 Piperidine-Based Drugs Used in the Treatment of Rheumatoid Arthritis -- 10.25 Piperidine-Based Nicotinic Cholinomimetics -- 10.26 Piperidine-Based Immunosuppresant Drugs -- 10.27 Conclusion -- Index-Trade Names -- Index-Substance Classes -- Back Cover

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Piperidine-Based Drug Discovery

Piperidine-Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Heterocyclic Drug Discovery
  • Release Date : 2017-06-14
  • ISBN : 0128051574
GET THIS BOOKPiperidine-Based Drug Discovery

10.22 Piperidine-Based Gastric Antisecretory Drugs -- 10.23 Piperidine-Based Hypoglycemic Drugs -- 10.24 Piperidine-Based Drugs Used in the Treatment of Rheumatoid Arthritis -- 10.25 Piperidine-Based Nicotinic Cholinomimetics -- 10.26 Piperidine-Based Immunosuppresant Drugs -- 10.27 Conclusion -- Index-Trade Names -- Index-Substance Classes -- Back Cover

Piperidine-Based Drug Discovery

Piperidine-Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release Date : 2017-06-12
  • ISBN : 9780128134283
GET THIS BOOKPiperidine-Based Drug Discovery

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central

Small Molecule Scaffold Synthesis, One-bead One-compound Library Synthesis, and Method Development in Drug Discovery

Small Molecule Scaffold Synthesis, One-bead One-compound Library Synthesis, and Method Development in Drug Discovery
  • Author : Seth M. Dixon
  • Publisher : Unknown
  • Release Date : 2006
  • ISBN : UCAL:X74600
GET THIS BOOKSmall Molecule Scaffold Synthesis, One-bead One-compound Library Synthesis, and Method Development in Drug Discovery

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks
  • Author : Jie Jack Li,Minmin Yang
  • Publisher : CRC Press
  • Release Date : 2021-10-21
  • ISBN : 9781000416015
GET THIS BOOKDrug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-07-15
  • ISBN : 9781782627913
GET THIS BOOKSynthetic Methods in Drug Discovery

Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • ISBN : 9781118686355
GET THIS BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-27
  • ISBN : 9781118145661
GET THIS BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Fragment-based Drug Discovery

Fragment-based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • ISBN : 9783527337750
GET THIS BOOKFragment-based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Synthesis of Essential Drugs

Synthesis of Essential Drugs
  • Author : Ruben Vardanyan,Victor Hruby
  • Publisher : Elsevier
  • Release Date : 2006-03-10
  • ISBN : 008046212X
GET THIS BOOKSynthesis of Essential Drugs

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active

Tailored Functional Materials

Tailored Functional Materials
  • Author : Kalisadhan Mukherjee,Rama Kanta Layek,Debasis De
  • Publisher : Springer Nature
  • Release Date : 2022-10-17
  • ISBN : 9789811925726
GET THIS BOOKTailored Functional Materials

This book presents the select proceedings of the International Symposium entitled “Materials of the Millennium: Emerging Trends and Future Prospects” (MMETFP 2021). It discusses the synthesis, tailoring, and characterization of different materials for functional applications in various sectors which include but not limited to energy, environment, biomedical/ health care, construction, transportation etc. Topics covered in this book are synthesis and characterization of polymers, ceramics, composites, biomaterials, carbon-based nanostructures as well as materials for green environment, structural materials, modeling and simulation of

Peptide-based Drug Discovery

Peptide-based Drug Discovery
  • Author : Ved Srivastava
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-06-22
  • ISBN : 9781788011716
GET THIS BOOKPeptide-based Drug Discovery

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes

High-Throughput Lead Optimization in Drug Discovery

High-Throughput Lead Optimization in Drug Discovery
  • Author : Tushar Kshirsagar
  • Publisher : CRC Press
  • Release Date : 2008-03-04
  • ISBN : 9781420006964
GET THIS BOOKHigh-Throughput Lead Optimization in Drug Discovery

A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
  • Author : Robert Stroud,Janet Finer-Moore
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • ISBN : 9781847557964
GET THIS BOOKComputational and Structural Approaches to Drug Discovery

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This

Peptidomimetics in Organic and Medicinal Chemistry

Peptidomimetics in Organic and Medicinal Chemistry
  • Author : Antonio Guarna,Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release Date : 2014-03-14
  • ISBN : 9781118683149
GET THIS BOOKPeptidomimetics in Organic and Medicinal Chemistry

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres,

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release Date : 2020-04-09
  • ISBN : 9780128175927
GET THIS BOOKGreen Approaches in Medicinal Chemistry for Sustainable Drug Design

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and