Organ on a chip

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  • Publisher : Academic Press
  • Release : 09 November 2019
  • ISBN : 9780128172032
  • Page : 546 pages
  • Rating : 4.5/5 from 103 voters

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Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Includes case studies of other organs on a chip that have been developed and successfully used Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

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Organ-on-a-chip

Organ-on-a-chip
  • Author : Julia Hoeng,David Bovard,Manuel Peitsch
  • Publisher : Academic Press
  • Release Date : 2019-11-09
  • ISBN : 9780128172032
GET THIS BOOKOrgan-on-a-chip

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations

Organ-on-a-chip

Organ-on-a-chip
  • Author : Marco Rasponi
  • Publisher : Unknown
  • Release Date : 2022
  • ISBN : 1071616935
GET THIS BOOKOrgan-on-a-chip

This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series,

Organs-on-chips

Organs-on-chips
  • Author : Yu-suke Torisawa,Yi-Chung Tung
  • Publisher : MDPI
  • Release Date : 2020-05-27
  • ISBN : 9783039289172
GET THIS BOOKOrgans-on-chips

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability

Lab-on-a-Chip Fabrication and Application

Lab-on-a-Chip Fabrication and Application
  • Author : Margarita Stoytcheva,Roumen Zlatev
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-29
  • ISBN : 9789535124573
GET THIS BOOKLab-on-a-Chip Fabrication and Application

The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.

The Organ Thieves

The Organ Thieves
  • Author : Chip Jones
  • Publisher : Simon and Schuster
  • Release Date : 2020-08-18
  • ISBN : 9781982107543
GET THIS BOOKThe Organ Thieves

The Immortal Life of Henrietta Lacks meets Get Out in this “startling…powerful” (Kirkus Reviews) investigation of racial inequality at the core of the heart transplant race. In 1968, Bruce Tucker, a black man, went into Virginia’s top research hospital with a head injury, only to have his heart taken out of his body and put into the chest of a white businessman. Now, in The Organ Thieves, Pulitzer Prize–nominated journalist Chip Jones exposes the horrifying inequality surrounding Tucker’

Animal Experimentation

Animal Experimentation
  • Author : Kathrin Herrmann,Kimberley Jayne
  • Publisher : Human-Animal Studies
  • Release Date : 2019
  • ISBN : 9004356185
GET THIS BOOKAnimal Experimentation

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip
  • Author : Xiujun James Li,Chaoyong Yang,Paul C. H. Li
  • Publisher : Newnes
  • Release Date : 2021-09-19
  • ISBN : 9780444594617
GET THIS BOOKMultidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and

Regenerative Medicine Technology

Regenerative Medicine Technology
  • Author : Sean V. Murphy,Anthony Atala
  • Publisher : CRC Press
  • Release Date : 2016-11-30
  • ISBN : 9781315354156
GET THIS BOOKRegenerative Medicine Technology

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
  • Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
  • Publisher : Woodhead Publishing
  • Release Date : 2020-03-20
  • ISBN : 9780081029077
GET THIS BOOKBiomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on

Cardiac Cell Culture Technologies

Cardiac Cell Culture Technologies
  • Author : Zbigniew Brzozka,Elzbieta Jastrzebska
  • Publisher : Springer
  • Release Date : 2017-11-21
  • ISBN : 9783319706856
GET THIS BOOKCardiac Cell Culture Technologies

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and

Microsystems for Pharmatechnology

Microsystems for Pharmatechnology
  • Author : Andreas Dietzel
  • Publisher : Springer
  • Release Date : 2016-01-22
  • ISBN : 9783319269207
GET THIS BOOKMicrosystems for Pharmatechnology

This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models
  • Author : J. Miguel Oliveira,Rui L. Reis
  • Publisher : Springer Nature
  • Release Date : 2020-04-13
  • ISBN : 9783030365882
GET THIS BOOKBiomaterials- and Microfluidics-Based Tissue Engineered 3D Models

This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for

Cutting-Edge Enabling Technologies for Regenerative Medicine

Cutting-Edge Enabling Technologies for Regenerative Medicine
  • Author : Heung Jae Chun,Chan Hum Park,Il Keun Kwon,Gilson Khang
  • Publisher : Springer
  • Release Date : 2018-10-24
  • ISBN : 9789811309502
GET THIS BOOKCutting-Edge Enabling Technologies for Regenerative Medicine

This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive

Biomimetic Microengineering

Biomimetic Microengineering
  • Author : Hyun Jung Kim
  • Publisher : CRC Press
  • Release Date : 2020-01-16
  • ISBN : 9781000725667
GET THIS BOOKBiomimetic Microengineering

This book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
  • Author : Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
  • Publisher : William Andrew
  • Release Date : 2012-12-31
  • ISBN : 9781437734607
GET THIS BOOKMicrofluidic Cell Culture Systems

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles