Successes and Challenges of NK Immunotherapy

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  • Publisher : Academic Press
  • Release : 23 June 2021
  • ISBN : 9780128243961
  • Page : 538 pages
  • Rating : 4.5/5 from 103 voters

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Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

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Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
  • Author : Benjamin Bonavida,Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2021-06-23
  • ISBN : 9780128243961
GET THIS BOOKSuccesses and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application

NK Cell-Based Cancer Immunotherapy

NK Cell-Based Cancer Immunotherapy
  • Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
  • Publisher : Frontiers Media SA
  • Release Date : 2016-09-08
  • ISBN : 9782889199341
GET THIS BOOKNK Cell-Based Cancer Immunotherapy

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine

NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy

NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy
  • Author : Erik Wennerberg,Andreas Lundqvist,Yumeng Mao,Dimitrios Mougiakakos
  • Publisher : Frontiers Media SA
  • Release Date : 2021-09-08
  • ISBN : 9782889712717
GET THIS BOOKNK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy

NK Cells in Cancer Immunotherapy

NK Cells in Cancer Immunotherapy
  • Author : Lynda Addou-Klouche
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : OCLC:1154268044
GET THIS BOOKNK Cells in Cancer Immunotherapy

Natural killer (NK) cells are crucial components of the innate immune system and play critical roles in host immunity against viral infections and cancer. NK cells' activity is controlled by the interaction of a wide range of receptors expressed on their surfaces with cell surface ligands. Opposite signals delivered by inhibitory and activating receptors tightly regulate NK cells' cytotoxicity. Natural killer cells can discriminate between normal and cancer cells. NK cells are known to directly recognize and kill malignant cells

Tumor Progression and Therapeutic Resistance

Tumor Progression and Therapeutic Resistance
  • Author : Wafik S. El-Deiry
  • Publisher : Unknown
  • Release Date : 2005
  • ISBN : UVA:X030000978
GET THIS BOOKTumor Progression and Therapeutic Resistance

This volume presents the entire breadth of translational cancer research and brings together members of academia and industry in the expectation of accelerating interactions and progress in the field. A variety of key topics are presented, beginning with discovery of molecular targets and pathways (oncogene, cell survival, tumor suppression, cell death), host-neoplasm interactions (cell adhesion, matrix proteases), early detection, monitoring progression, understanding tumor progression and metastasis, immune surveillance, in vivo molecular imaging, animal models, drug discovery including chemistry, high-throughput assays,

Cancer Immunotherapy

Cancer Immunotherapy
  • Author : Sarah S. Donatelli,Julie Y. Djeu
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • ISBN : 9780128059050
GET THIS BOOKCancer Immunotherapy

Natural Killer (NK) cells are a unique subset of lymphocytes genetically programmed to locate and destroy cellular malignancies. They accomplish this through unique cell surface receptors that, upon contacting a target cell, transmit either inhibitory or activating intracellular signals, ultimately determining whether the target cell will be killed or spared. Acquisition of the capacity to kill comes only after the NK cell is rendered tolerant to healthy self cells through interaction with naturally expressed MHC I molecules. The resulting functional

Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer

Molecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer
  • Author : Loredana Cifaldi,Daniel Olive,James Di Santo
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-31
  • ISBN : 9782889638765
GET THIS BOOKMolecular Strategies Aimed to Boost NK Cell-based Immunotherapy of Cancer

In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

Immunotherapy

Immunotherapy
  • Author : Krassimir Metodiev
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-26
  • ISBN : 9789535131052
GET THIS BOOKImmunotherapy

This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ideas of application of modern immunomodulation. It is always a benefit, but also a compliment, to gather a team of internationally distinguished authors and to motivate them to reveal their

Natural Killer Cells

Natural Killer Cells
  • Author : Michael T. Lotze,Angus W. Thomson
  • Publisher : Academic Press
  • Release Date : 2009-11-12
  • ISBN : 0080919294
GET THIS BOOKNatural Killer Cells

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage

Clinical Applications of Natural Killer Cells

Clinical Applications of Natural Killer Cells
  • Author : Yui Harada
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : OCLC:1154297547
GET THIS BOOKClinical Applications of Natural Killer Cells

Natural killer (NK) cells are an essential component of the innate immune system, and they play a crucial role in immunity against malignancies. Recent advances in our understanding of NK cell biology have paved the way for new therapeutic strategies based on NK cells for the treatment of various cancers. In this section, we will focus on NK cell immunotherapy, including the enhancement of antibody-dependent cellular cytotoxicity, the manipulation of receptor-mediated activation, inclusion criteria based on killer cell immunoglobulin-like receptor (

Natural Killer Cells

Natural Killer Cells
  • Author : Jacques Zimmer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-01-12
  • ISBN : 9783642023095
GET THIS BOOKNatural Killer Cells

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad

Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology
  • Author : Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O’Sullivan
  • Publisher : Springer Nature
  • Release Date : 2021-06-02
  • ISBN : 9783030632342
GET THIS BOOKCritical Issues in Head and Neck Oncology

This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck

Natural Killer Cells: the Future of Cancer Immunotherapy

Natural Killer Cells: the Future of Cancer Immunotherapy
  • Author : Priyanka Senthil
  • Publisher : Unknown
  • Release Date : 2020-04-20
  • ISBN : 9798638783372
GET THIS BOOKNatural Killer Cells: the Future of Cancer Immunotherapy

Cellular therapeutics is an emerging field with significant advances in the engineering of immune effector cells that play a revolutionary role in treatment for cancer. Up until now, most immunomodulatory strategies focus on enhancing T cells, which are lymphocyte immune cells that are important for cell-mediated immunity to fight pathogens and cancer. T cells have proven their ability in successful cellular therapies against leukemia, but may soon face competition. Through several preclinical studies, researchers have discovered new guardian immune cells

Gene and Cellular Immunotherapy for Cancer

Gene and Cellular Immunotherapy for Cancer
  • Author : Armin Ghobadi
  • Publisher : Springer Nature
  • Release Date : 2022-09-29
  • ISBN : 9783030878498
GET THIS BOOKGene and Cellular Immunotherapy for Cancer

Tumor Immunology and Immunotherapy

Tumor Immunology and Immunotherapy
  • Author : Robert C. Rees
  • Publisher : OUP Oxford
  • Release Date : 2014-05-29
  • ISBN : 9780191664557
GET THIS BOOKTumor Immunology and Immunotherapy

Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer