Molecular and Cellular Therapies for Motor Neuron Diseases

Book Molecular and Cellular Therapies for Motor Neuron Diseases Cover

Read or download book entitled Molecular and Cellular Therapies for Motor Neuron Diseases written by Nicholas M Boulis and published by Academic Press in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that Molecular and Cellular Therapies for Motor Neuron Diseases book is available in the library.

  • Publisher : Academic Press
  • Release : 18 January 2017
  • ISBN : 9780128025246
  • Page : 336 pages
  • Rating : 4.5/5 from 103 voters

Download Molecular and Cellular Therapies for Motor Neuron Diseases in PDF, Epub and Kindle

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

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Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases
  • Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
  • Publisher : Academic Press
  • Release Date : 2017-01-18
  • ISBN : 9780128025246
GET THIS BOOKMolecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms.

Novel Aspects on Motor Neuron Disease

Novel Aspects on Motor Neuron Disease
  • Author : Humberto Foyaca Sibat,Lourdes de Fátima Ibañez-Valdés
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-05-20
  • ISBN : 9781838807733
GET THIS BOOKNovel Aspects on Motor Neuron Disease

Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis
  • Author : Ricardo Tapia
  • Publisher : Frontiers Media SA
  • Release Date : 2015-02-11
  • ISBN : 9782889193769
GET THIS BOOKCellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS),

Motor Neuron Disease in Adults

Motor Neuron Disease in Adults
  • Author : Mark Bromberg
  • Publisher : Oxford University Press
  • Release Date : 2014-10-02
  • ISBN : 9780190202262
GET THIS BOOKMotor Neuron Disease in Adults

Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on

The Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease
  • Author : Patrick A. Lewis,Jennifer E. Spillane
  • Publisher : Academic Press
  • Release Date : 2018-11-16
  • ISBN : 9780128110706
GET THIS BOOKThe Molecular and Clinical Pathology of Neurodegenerative Disease

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a

The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments

The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
  • Author : Manoj Kumar Jaiswal
  • Publisher : Frontiers Media SA
  • Release Date : 2017-04-17
  • ISBN : 9782889451463
GET THIS BOOKThe Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is

The Future of Pharmaceuticals

The Future of Pharmaceuticals
  • Author : Sarfaraz K. Niazi
  • Publisher : CRC Press
  • Release Date : 2022-03-01
  • ISBN : 9781000458169
GET THIS BOOKThe Future of Pharmaceuticals

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences.

Gene and Cell Therapy

Gene and Cell Therapy
  • Author : Nancy Smyth Templeton
  • Publisher : CRC Press
  • Release Date : 2003-12-17
  • ISBN : 9780824758608
GET THIS BOOKGene and Cell Therapy

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and

New Insights Into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair

New Insights Into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair
  • Author : Jose Angel Morales-Garcia,Naoko Kaneko,Vicente Herranz-Pérez
  • Publisher : Frontiers Media SA
  • Release Date : 2022-04-04
  • ISBN : 9782889749089
GET THIS BOOKNew Insights Into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair

Translational Neuroscience

Translational Neuroscience
  • Author : Mark H. Tuszynski
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : 1489976531
GET THIS BOOKTranslational Neuroscience

Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging

TDP-43 and Neurodegeneration

TDP-43 and Neurodegeneration
  • Author : Vijay Kumar,Manoj Kumar Jaiswal
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • ISBN : 9780128204405
GET THIS BOOKTDP-43 and Neurodegeneration

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells

Cell Press Reviews: Stem Cells to Model and Treat Disease

Cell Press Reviews: Stem Cells to Model and Treat Disease
  • Author : Cell Press
  • Publisher : Elsevier
  • Release Date : 2013-12-03
  • ISBN : 9780127999166
GET THIS BOOKCell Press Reviews: Stem Cells to Model and Treat Disease

Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatments Stem-cell-based organ regeneration Integrating stem cells into personalized drug discovery Using pluripotent stem cells

The Management of Motor Neurone Disease

The Management of Motor Neurone Disease
  • Author : George M. Cochrane
  • Publisher : Unknown
  • Release Date : 1987
  • ISBN : UOM:39015012536432
GET THIS BOOKThe Management of Motor Neurone Disease

Programmed Cells from Basic Neuroscience to Therapy

Programmed Cells from Basic Neuroscience to Therapy
  • Author : Fred H. Gage,Yves Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-05-13
  • ISBN : 9783642366482
GET THIS BOOKProgrammed Cells from Basic Neuroscience to Therapy

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons

Dementia and Motor Neuron Disease

Dementia and Motor Neuron Disease
  • Author : Michael Strong
  • Publisher : CRC Press
  • Release Date : 2006-07-27
  • ISBN : 0415391660
GET THIS BOOKDementia and Motor Neuron Disease

Dementia and Motor Neuron Disease is a single authoritative reference on the current understanding of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This comprehensive work is ideal for clinical and research groups focusing on dementia or ALS, as well as those working in the fields of neuroimaging and neuropsychology. Key topics covered include: • Frontotemporal dementia, including history, anatomy and impairment • Clinical phenomenology and treatment • Neuropathological, cognitive dysfunction and altered cognition spectrums • Neuroimaging • Molecular and cellular neuropathology • Genetics • Neurochemistry With contributions