Translating MicroRNAs to the Clinic

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  • Publisher : Academic Press
  • Release : 17 September 2016
  • ISBN : 9780128005545
  • Page : 392 pages
  • Rating : 4.5/5 from 103 voters

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Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply microRNA from lab to clinic“/li> Extensive pedagogical updates aiming to improve the education of translational researchers in this field Transdisciplinary approach aims to support cross-fertilization between different sub-specialties of medicine

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Translating MicroRNAs to the Clinic

Translating MicroRNAs to the Clinic
  • Author : Jeffrey Laurence
  • Publisher : Academic Press
  • Release Date : 2016-09-17
  • ISBN : 9780128005545
GET THIS BOOKTranslating MicroRNAs to the Clinic

Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
  • Author : Suming Huang,Michael D Litt,C. Ann Blakey
  • Publisher : Academic Press
  • Release Date : 2015-10-19
  • ISBN : 9780128004715
GET THIS BOOKEpigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Quan Lin,Yi E. Sun
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2012-12-31
  • ISBN : 9780128058442
GET THIS BOOKEpigenetic Regulation in the Nervous System

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-02-06
  • ISBN : 9780128145142
GET THIS BOOKComputational Epigenetics and Diseases

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease,

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
  • Author : José Luis García-Giménez
  • Publisher : Academic Press
  • Release Date : 2015-12-07
  • ISBN : 9780128019214
GET THIS BOOKEpigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e.

MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets

MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets
  • Author : Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-05-21
  • ISBN : 9781788013949
GET THIS BOOKMicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA

Epigenetics of B Cells and Antibody Responses

Epigenetics of B Cells and Antibody Responses
  • Author : Paolo Casali
  • Publisher : Frontiers Media SA
  • Release Date : 2016-04-12
  • ISBN : 9782889197903
GET THIS BOOKEpigenetics of B Cells and Antibody Responses

Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and

Epigenetic Alterations in Oncogenesis

Epigenetic Alterations in Oncogenesis
  • Author : Adam R. Karpf
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-06
  • ISBN : 9781441999672
GET THIS BOOKEpigenetic Alterations in Oncogenesis

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia

Epigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia
  • Author : Constance Regina Bär
  • Publisher : Unknown
  • Release Date : 2013
  • ISBN : OCLC:869014201
GET THIS BOOKEpigenetic Regulation of MicroRNAs in Chronic Lymphocytic Leukemia

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release Date : 2017-10-13
  • ISBN : 9780128134375
GET THIS BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
  • Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
  • Publisher : Unknown
  • Release Date : 1996
  • ISBN : UOM:39015047449171
GET THIS BOOKEpigenetic Mechanisms of Gene Regulation

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects

Essentials of Noncoding RNA in Neuroscience

Essentials of Noncoding RNA in Neuroscience
  • Author : Davide De Pietri Tonelli
  • Publisher : Academic Press
  • Release Date : 2017-06-14
  • ISBN : 9780128498996
GET THIS BOOKEssentials of Noncoding RNA in Neuroscience

Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in

Prognostic Epigenetics

Prognostic Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-11-01
  • ISBN : 9780128142608
GET THIS BOOKPrognostic Epigenetics

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can

Non-coding RNAs and Epigenetic Regulation of Gene Expression

Non-coding RNAs and Epigenetic Regulation of Gene Expression
  • Author : Kevin V. Morris
  • Publisher : Horizon Scientific Press
  • Release Date : 2012
  • ISBN : 1904455948
GET THIS BOOKNon-coding RNAs and Epigenetic Regulation of Gene Expression

Non-coding RNAs potentially play an active role in modulating gene transcription and epigenetic states. Several genes in differentiated cells may be under some form of RNA-based transcriptional and epigenetic regulatory control. This form of regulation may be controlled by selective pressures and influence the adaptability of the cell. The concept that RNA can control epigenetic states impacts our understanding of the basic fabric of the cell and may have therapeutic potential. Many studies have been carried out on the modulation

Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection
  • Author : Sudhir Srivastava
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-07
  • ISBN : 9781118468821
GET THIS BOOKBiomarkers in Cancer Screening and Early Detection

Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to