Intrinsically Disordered Proteins

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  • Publisher : Humana
  • Release : 23 July 2021
  • ISBN : 1071605267
  • Page : 951 pages
  • Rating : 4.5/5 from 103 voters

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The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Birthe B. Kragelund,Karen Skriver
  • Publisher : Humana
  • Release Date : 2021-07-23
  • ISBN : 1071605267
GET THIS BOOKIntrinsically Disordered Proteins

The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Vladimir N. Uversky
  • Publisher : Springer
  • Release Date : 2014-08-05
  • ISBN : 9783319089218
GET THIS BOOKIntrinsically Disordered Proteins

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Nicola Salvi
  • Publisher : Academic Press
  • Release Date : 2019-06-14
  • ISBN : 9780128167328
GET THIS BOOKIntrinsically Disordered Proteins

Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and

Structure and Function of Intrinsically Disordered Proteins

Structure and Function of Intrinsically Disordered Proteins
  • Author : Peter Tompa,Alan Fersht
  • Publisher : CRC Press
  • Release Date : 2009-11-18
  • ISBN : 1420078933
GET THIS BOOKStructure and Function of Intrinsically Disordered Proteins

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Intrinsically Disordered Proteins Studied by NMR Spectroscopy
  • Author : Isabella C. Felli,Roberta Pierattelli
  • Publisher : Springer
  • Release Date : 2015-09-19
  • ISBN : 9783319201641
GET THIS BOOKIntrinsically Disordered Proteins Studied by NMR Spectroscopy

This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology
  • Author : Vladimir Uversky
  • Publisher : Academic Press
  • Release Date : 2019-09-15
  • ISBN : 9780128168516
GET THIS BOOKDancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the

Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental Analysis of Intrinsically Disordered Proteins
  • Author : Vladimir Uversky,Sonia Longhi
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-31
  • ISBN : 0470602600
GET THIS BOOKInstrumental Analysis of Intrinsically Disordered Proteins

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Springer
  • Release Date : 2012-07-21
  • ISBN : 1461437059
GET THIS BOOKIntrinsically Disordered Protein Analysis

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
  • Author : Jean-Paul Renaud
  • Publisher : John Wiley & Sons
  • Release Date : 2020-01-09
  • ISBN : 9781118900505
GET THIS BOOKStructural Biology in Drug Discovery

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable

Biomolecular Forms and Functions

Biomolecular Forms and Functions
  • Author : Manju Bansal,N. Srinivasan
  • Publisher : World Scientific
  • Release Date : 2013
  • ISBN : 9789814449144
GET THIS BOOKBiomolecular Forms and Functions

This volume is primarily a compilation of contributed articles representing the impact and application of Ramachandran's work on conformation analysis of biopolymers, as well as recent advances in macromolecular structural biology, involving diverse experimental and computational approaches. This volume is being published to coincide with a conference on "Biomolecular Forms and Functions: A celebration of 50 years of the Ramachandran Map" being held at the Indian Institute of Science, Bangalore, in January 2013.

Fuzziness

Fuzziness
  • Author : Monika Fuxreiter,Peter Tompa
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-03-07
  • ISBN : 9781461406594
GET THIS BOOKFuzziness

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-10-14
  • ISBN : 9780323853002
GET THIS BOOKDancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Springer
  • Release Date : 2012-07-21
  • ISBN : 1461437032
GET THIS BOOKIntrinsically Disordered Protein Analysis

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on

NMR of Biomolecules

NMR of Biomolecules
  • Author : Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-16
  • ISBN : 9783527328505
GET THIS BOOKNMR of Biomolecules

NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

Advances in Protein Molecular and Structural Biology Methods

Advances in Protein Molecular and Structural Biology Methods
  • Author : Timir Tripathi,Vikash Kumar Dubey
  • Publisher : Academic Press
  • Release Date : 2022-01-14
  • ISBN : 9780323902656
GET THIS BOOKAdvances in Protein Molecular and Structural Biology Methods

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied