In Vitro Toxicology

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  • Publisher : Academic Press
  • Release : 13 November 2017
  • ISBN : 9780128047712
  • Page : 248 pages
  • Rating : 4.5/5 from 103 voters

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In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. Discusses new techniques and protocols in a clear and concise manner includes examinations of nanotoxicity, genotoxicity and carcinogenicity Explains practical laboratory methods and the theories behind in vitro testing

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In Vitro Toxicology

In Vitro Toxicology
  • Author : Alok Dhawan,Seok (Soga) Kwon
  • Publisher : Academic Press
  • Release Date : 2017-11-13
  • ISBN : 9780128047712
GET THIS BOOKIn Vitro Toxicology

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance

In Vitro Toxicology Systems

In Vitro Toxicology Systems
  • Author : Anna Bal-Price,Paul Jennings
  • Publisher : Humana Press
  • Release Date : 2014-05-01
  • ISBN : 1493905201
GET THIS BOOKIn Vitro Toxicology Systems

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism,

In Vitro Toxicity Testing Protocols

In Vitro Toxicity Testing Protocols
  • Author : Sheila O’Hare,C. K. Atterwill
  • Publisher : Humana Press
  • Release Date : 1995-05-04
  • ISBN : UOM:39015037494393
GET THIS BOOKIn Vitro Toxicity Testing Protocols

In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement

Genetic Toxicology Testing

Genetic Toxicology Testing
  • Author : Ray Proudlock
  • Publisher : Academic Press
  • Release Date : 2016-05-28
  • ISBN : 9780128010068
GET THIS BOOKGenetic Toxicology Testing

Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in

Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

Reducing, Refining and Replacing the Use of Animals in Toxicity Testing
  • Author : Dave Allen,Mike D. Waters
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013
  • ISBN : 9781849736527
GET THIS BOOKReducing, Refining and Replacing the Use of Animals in Toxicity Testing

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available

In Vitro Methods in Pharmaceutical Research

In Vitro Methods in Pharmaceutical Research
  • Author : Jose V. Castell,Maria Jose Gmez-Lechn
  • Publisher : Elsevier
  • Release Date : 1996-10-04
  • ISBN : 0080534600
GET THIS BOOKIn Vitro Methods in Pharmaceutical Research

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. Meets the continuing demand for information in

Principles of Toxicology Testing

Principles of Toxicology Testing
  • Author : Frank A Barile
  • Publisher : CRC Press
  • Release Date : 2013-04-02
  • ISBN : 9781842145296
GET THIS BOOKPrinciples of Toxicology Testing

Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, includin

Animal Experimentation

Animal Experimentation
  • Author : Kathrin Herrmann,Kimberley Jayne
  • Publisher : Human-Animal Studies
  • Release Date : 2019
  • ISBN : 9004356185
GET THIS BOOKAnimal Experimentation

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Validation of Alternative Methods for Toxicity Testing

Validation of Alternative Methods for Toxicity Testing
  • Author : Chantra Eskes,Maurice Whelan
  • Publisher : Springer
  • Release Date : 2016-09-26
  • ISBN : 9783319338262
GET THIS BOOKValidation of Alternative Methods for Toxicity Testing

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are

In Vitro Toxicology, Second Edition

In Vitro Toxicology, Second Edition
  • Author : Shayne C. Gad
  • Publisher : CRC Press
  • Release Date : 2000-11-02
  • ISBN : 9781560327691
GET THIS BOOKIn Vitro Toxicology, Second Edition

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists

Drug Discovery Toxicology

Drug Discovery Toxicology
  • Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-22
  • ISBN : 9781119053392
GET THIS BOOKDrug Discovery Toxicology

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers

Standard Operating Procedures In Vitro Toxicology

Standard Operating Procedures In Vitro Toxicology
  • Author : I.P. Sword,S.D. Thomson
  • Publisher : Springer
  • Release Date : 2011-10-09
  • ISBN : 940098717X
GET THIS BOOKStandard Operating Procedures In Vitro Toxicology

When Volume 1 (Toxicolpgy) in this series of Standard Operating Procedures was pub lished in early 1979, the FDA's Good Laboratory Practice Regulations did not have the force of United States Law, but nevertheless had a substantial impact on the conduct of toxicology in laboratories throughout the world. These Regulations are now in force, and Volume 2 (Pathology) was published later the same year. Our critics have implied that we have attempted to reduce toxicology to the level of the cookery book, or

In Vitro Toxicology

In Vitro Toxicology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : OCLC:1010416721
GET THIS BOOKIn Vitro Toxicology

Alternative Toxicological Methods

Alternative Toxicological Methods
  • Author : Harry Salem,Sidney A. Katz
  • Publisher : CRC Press
  • Release Date : 2003-03-26
  • ISBN : 9780203008799
GET THIS BOOKAlternative Toxicological Methods

Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist

In Vitro Toxicology

In Vitro Toxicology
  • Author : Alan M. Goldberg
  • Publisher : Mary Ann Liebert
  • Release Date : 1985
  • ISBN : UCAL:$B319480
GET THIS BOOKIn Vitro Toxicology