Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

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  • Publisher : Academic Press
  • Release : 17 December 2021
  • ISBN : 9780128204436
  • Page : 242 pages
  • Rating : 5/5 from 1 voters

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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases Elucidates neurogenetics of gene APP, gene PSEN1, gene APOE, gene LRRK2, gene DJ1, and others in the pathology of neurodegenerative diseases. Explains caspases-mediated neuronal apoptosis in pathogenesis of Alzheimer’s disease covering amyloidogenesis, caspase-activated DNase, rho-associated coiled coil–containing protein kinase 1, mammalian sterile 20-like kinase 1, role of synaptic loss, microglial TREM2 receptor, microglial LRP1 receptor, microglial advanced glycation end-product receptor, astrocytic glial a 7 subtypes of nAChR, NLRP3 inflammasome, P2X purinoreceptors, miRNAs, and many other factors Demonstrates the role of caspases and apoptosis in Parkinson’s disease covering truncation of a-synuclein, neuroinflammation, parkin protein, activation of microglial cells, extrinsic and intrinsic pathways of apoptosis, ?tau314, and several other factors Explains etiopathogenesis of Huntington’s disease through covering clinically important topics as role of exon 1 HTT protein, ubiquitous nature of huntingtin, length of expanded polyglutamine tract, classically and alternately activated microglia, nuclear factor kappa B, kynurenine signaling pathway, tumor suppressor protein, PGC-1a gene, advanced glycation end-products, autophagy, and many other significant topics.

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Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases
  • Author : Anil Gupta
  • Publisher : Academic Press
  • Release Date : 2021-12-17
  • ISBN : 9780128204436
GET THIS BOOKHuman Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus

Neurodegenerative Diseases

Neurodegenerative Diseases
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  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-15
  • ISBN : 9789535110880
GET THIS BOOKNeurodegenerative Diseases

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It

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  • Publisher : Humana Press
  • Release Date : 2014-11-28
  • ISBN : 1493921517
GET THIS BOOKNeuronal Cell Death

This volume represents a valuable and readily reproducible collection of established and emerging techniques for neuronal cell death research. Conveniently divided into four parts, sections cover a series of techniques for the molecular, structural, functional and genomic characterization of dying neurons, a number of protocols that are of primary interest in neuropathology and in experimental neuropathology, a series of gene engineering techniques to obtain and manipulate neuronal stem cells and progenitors, to prepare HSV-1 vectors for the gene therapy, and

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
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  • Publisher : University of Adelaide Press
  • Release Date : 2011
  • ISBN : 9780987073051
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

Adenoviral Vector-mediated Gene Delivery of Dominant-negative Caspase-9 (Casp9DN) Prevents 6-hydroxydopamine (6-OHDA)-induced Death of Dopaminergic Neurons in Cell Culture, But Not in an Adult Rat Model of Parkinson's Disease

Adenoviral Vector-mediated Gene Delivery of Dominant-negative Caspase-9 (Casp9DN) Prevents 6-hydroxydopamine (6-OHDA)-induced Death of Dopaminergic Neurons in Cell Culture, But Not in an Adult Rat Model of Parkinson's Disease
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  • Publisher : Unknown
  • Release Date : 2005
  • ISBN : OCLC:61322392
GET THIS BOOKAdenoviral Vector-mediated Gene Delivery of Dominant-negative Caspase-9 (Casp9DN) Prevents 6-hydroxydopamine (6-OHDA)-induced Death of Dopaminergic Neurons in Cell Culture, But Not in an Adult Rat Model of Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder induced by the selective loss of neurons in the brain stem producing the neurotransmitter dopamine (DA). One role for DA is to modulate motor capabilities, and PD is clinically diagnosed by the appearance of various motor disturbances. To date, the cause of sporadic PD is largely unknown. Intense research is underway utilizing PD models to study disease progression and neuronal loss with the goal of developing therapies that halt DA neuron loss, rejuvenate

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Role of Proteases in the Pathophysiology of Neurodegenerative Diseases
  • Author : Abel Lajtha,Naren L. Banik
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-08
  • ISBN : 9780306468476
GET THIS BOOKRole of Proteases in the Pathophysiology of Neurodegenerative Diseases

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by

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  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-28
  • ISBN : 9783211735749
GET THIS BOOKNeuropsychiatric Disorders

This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Mechanism of Reversal of Alzheimer's Disease A-beta Induced Neuronal Degeneration in Cultured Human SHSY Cells Using a Neurotrophic Ependymin Mimetic

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  • Publisher : Unknown
  • Release Date : 2007
  • ISBN : OCLC:181739072
GET THIS BOOKMechanism of Reversal of Alzheimer's Disease A-beta Induced Neuronal Degeneration in Cultured Human SHSY Cells Using a Neurotrophic Ependymin Mimetic

Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that leads to dementia in adults. The mechanism of neurodegeneration is thought to involve the extracellular production of a highly toxic A-beta peptide that engages cell surface receptors to induce cellular oxidative stress and apoptosis, but the signal transduction pathways that lead to A-beta induced cell death are unknown. We previously showed that a human ependymin neurotrophic peptide mimetic (hEPN-1) can promote cell survival in an in vitro AD model system. This

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  • Publisher : Springer Science & Business Media
  • Release Date : 2009-02-28
  • ISBN : 0387788875
GET THIS BOOKCyclin Dependent Kinase 5 (Cdk5)

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation

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  • Publisher : World Scientific
  • Release Date : 2012
  • ISBN : 9789814350440
GET THIS BOOKAutophagy of the Nervous System

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons.

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  • Publisher : Cambridge University Press
  • Release Date : 2014-04-24
  • ISBN : 9781107011670
GET THIS BOOKTextbook of Neural Repair and Rehabilitation

Volume 1 of the Textbook of Neural Repair and Rehabilitation covers the basic sciences relevant to recovery of function following injury to the nervous system.

Molecular Mechanisms of Neurodegenerative Diseases

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  • Publisher : Springer Science & Business Media
  • Release Date : 2000-10-19
  • ISBN : 9781592590063
GET THIS BOOKMolecular Mechanisms of Neurodegenerative Diseases

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from

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  • Publisher : Oxford University Press, USA
  • Release Date : 2002
  • ISBN : 0195145232
GET THIS BOOKThe Neuron

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.

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  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-07
  • ISBN : 9783709167816
GET THIS BOOKAdvances in Dementia Research

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques,

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  • Author : Gorazd Drevensek
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-02
  • ISBN : 9781789230147
GET THIS BOOKSex Hormones in Neurodegenerative Processes and Diseases

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental