High Throughput Bioanalytical Sample Preparation

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Read or download book entitled High Throughput Bioanalytical Sample Preparation written by David A. Wells and published by Elsevier Science Limited in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that High Throughput Bioanalytical Sample Preparation book is available in the library.

  • Publisher : Elsevier Science Limited
  • Release : 28 January 2003
  • ISBN : UOM:39015056471918
  • Page : 648 pages
  • Rating : 4.5/5 from 103 voters

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High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. · Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies · Thorough literature review and summary of published information · Detailed discussion and examples of the method development process

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High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation
  • Author : David A. Wells
  • Publisher : Elsevier Science Limited
  • Release Date : 2003-01-28
  • ISBN : UOM:39015056471918
GET THIS BOOKHigh Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase

Applied Biological Engineering

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  • Publisher : BoD – Books on Demand
  • Release Date : 2012-03-23
  • ISBN : 9789535104124
GET THIS BOOKApplied Biological Engineering

Biological engineering is a field of engineering in which the emphasis is on life and life-sustaining systems. Biological engineering is an emerging discipline that encompasses engineering theory and practice connected to and derived from the science of biology. The most important trend in biological engineering is the dynamic range of scales at which biotechnology is now able to integrate with biological processes. An explosion in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug delivery into cells, miniaturized

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  • Author : Perry G. Wang
  • Publisher : CRC Press
  • Release Date : 2008-08-20
  • ISBN : 9781420059540
GET THIS BOOKHigh-Throughput Analysis in the Pharmaceutical Industry

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres

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  • Author : Nader Rifai
  • Publisher : Elsevier Health Sciences
  • Release Date : 2017-01-16
  • ISBN : 9780323548489
GET THIS BOOKTietz Textbook of Clinical Chemistry and Molecular Diagnostics

The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE

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  • Publisher : Elsevier Health Sciences
  • Release Date : 2022-02-03
  • ISBN : 9780323834674
GET THIS BOOKTietz Textbook of Laboratory Medicine - E-Book

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on

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  • Author : Wenkui Li,Wenying Jian,Yunlin Fu
  • Publisher : John Wiley & Sons
  • Release Date : 2019-02-25
  • ISBN : 9781119274322
GET THIS BOOKSample Preparation in LC-MS Bioanalysis

Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human

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  • Publisher : John Wiley & Sons
  • Release Date : 2011-03-31
  • ISBN : 047092280X
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This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it

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  • Author : Jack Rosenfeld
  • Publisher : John Wiley & Sons
  • Release Date : 2009-02-12
  • ISBN : 9781405148030
GET THIS BOOKSample Preparation for Hyphenated Analytical Techniques

Linking “standard” but often mutually incompatible analytical techniques – so called hyphenation – generally leads to enhanced analytical performance, so hyphenated techniques are widely used in areas where samples are presented in complex matrices, eg environmental, pharmaceutical and biochemical analysis. With these hyphenated techniques, sample preparation is often the most time-consuming step in analysis, particularly where compounds are present in low concentration, and it has a huge influence on the quality of the analytical results. Sample preparation is still not given the

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  • Publisher : Elsevier
  • Release Date : 2018-06-26
  • ISBN : 9780128160640
GET THIS BOOKPrinciples and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well

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  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-03
  • ISBN : 9781118671351
GET THIS BOOKHandbook of LC-MS Bioanalysis

Consolidates the information LC-MS bioanalytical scientistsneed to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by newapproaches for developing bioanalytical methods, new liquidchromatographic (LC) techniques, and new mass spectrometric (MS)instruments. Moreover, there are a host of guidelines andregulations designed to ensure the quality of bioanalyticalresults. Presenting the best practices, experimental protocols, and thelatest understanding of regulations, this book offers acomprehensive review of LC-MS bioanalysis of small molecules andmacromolecules. It not only addresses the needs

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  • Author : Wilfried M.A. Niessen
  • Publisher : CRC Press
  • Release Date : 2006-08-09
  • ISBN : 9781420014549
GET THIS BOOKLiquid Chromatography-Mass Spectrometry

A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and

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  • Author : Richard F. Venn
  • Publisher : CRC Press
  • Release Date : 2008-02-25
  • ISBN : 9781420005608
GET THIS BOOKPrinciples and Practice of Bioanalysis

In the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substance

Sample Preparation in LC-MS Bioanalysis

Sample Preparation in LC-MS Bioanalysis
  • Author : Wenkui Li,Wenying Jian,Yunlin Fu
  • Publisher : John Wiley & Sons
  • Release Date : 2019-03-12
  • ISBN : 9781119274292
GET THIS BOOKSample Preparation in LC-MS Bioanalysis

Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human

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  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-26
  • ISBN : 0470538945
GET THIS BOOKEnzyme Inhibition in Drug Discovery and Development

The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics,

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  • Author : Mike S. Lee
  • Publisher : John Wiley & Sons
  • Release Date : 2005-09-02
  • ISBN : 9780471721024
GET THIS BOOKIntegrated Strategies for Drug Discovery Using Mass Spectrometry

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug