GPCRs

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  • Publisher : Academic Press
  • Release : 11 September 2019
  • ISBN : 9780128167281
  • Page : 500 pages
  • Rating : 4.5/5 from 103 voters

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GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

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GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release Date : 2019-09-11
  • ISBN : 9780128167281
GET THIS BOOKGPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible

GPCR Signaling in Cancer

GPCR Signaling in Cancer
  • Author : Arun K. Shukla
  • Publisher : Academic Press
  • Release Date : 2020-02
  • ISBN : 9780128202302
GET THIS BOOKGPCR Signaling in Cancer

GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in

G-Protein-Coupled Receptor Dimers

G-Protein-Coupled Receptor Dimers
  • Author : Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni
  • Publisher : Humana Press
  • Release Date : 2017-09-12
  • ISBN : 3319601725
GET THIS BOOKG-Protein-Coupled Receptor Dimers

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information

G Protein-Coupled Receptors

G Protein-Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-01-05
  • ISBN : 9780128151082
GET THIS BOOKG Protein-Coupled Receptors

G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
  • Author : Denis J. Dupré,Terence E. Hébert,Ralf Jockers
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-11-19
  • ISBN : 9789400747654
GET THIS BOOKGPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs

Modelling of GPCRs

Modelling of GPCRs
  • Author : Andrea Strasser,Hans-Joachim Wittmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-08-13
  • ISBN : 9789400745964
GET THIS BOOKModelling of GPCRs

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling

Neuropeptide GPCRs in neuroendocrinology

Neuropeptide GPCRs in neuroendocrinology
  • Author : Jae Young Seong,Hubert Vaudry
  • Publisher : Frontiers E-books
  • Release Date : 2014-11-07
  • ISBN : 9782889192670
GET THIS BOOKNeuropeptide GPCRs in neuroendocrinology

The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of

Adhesion‐GPCRs

Adhesion‐GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-26
  • ISBN : 9781441979131
GET THIS BOOKAdhesion‐GPCRs

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders.

The Physiology and Pharmacology of Leucine-rich Repeat GPCRs

The Physiology and Pharmacology of Leucine-rich Repeat GPCRs
  • Author : Brian J. Arey,James A. Dias
  • Publisher : Frontiers Media SA
  • Release Date : 2016-08-05
  • ISBN : 9782889199587
GET THIS BOOKThe Physiology and Pharmacology of Leucine-rich Repeat GPCRs

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively

Ligand Design for G Protein-coupled Receptors, Volume 30

Ligand Design for G Protein-coupled Receptors, Volume 30
  • Author : Didier Rognan,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-10
  • ISBN : 3527312846
GET THIS BOOKLigand Design for G Protein-coupled Receptors, Volume 30

1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled

The G Protein-Coupled Receptors Handbook

The G Protein-Coupled Receptors Handbook
  • Author : Lakshmi A. Devi
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-01
  • ISBN : 9781592599196
GET THIS BOOKThe G Protein-Coupled Receptors Handbook

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as

Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors

Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors
  • Author : Sameer Mohammad,Muheeb Beg,Manveen Kaur Gupta
  • Publisher : Frontiers Media SA
  • Release Date : 2022-01-28
  • ISBN : 9782889742134
GET THIS BOOKCell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors

G Protein-Coupled Receptors

G Protein-Coupled Receptors
  • Author : Tatsuya Haga,Shigeki Takeda
  • Publisher : CRC Press
  • Release Date : 2005-08-04
  • ISBN : 9781420038279
GET THIS BOOKG Protein-Coupled Receptors

This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

GPCRs: From Deorphanization to Lead Structure Identification

GPCRs: From Deorphanization to Lead Structure Identification
  • Author : H. Bourne,Richard Horuk,J. Kuhnke,H. Michel
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-23
  • ISBN : 9783540489825
GET THIS BOOKGPCRs: From Deorphanization to Lead Structure Identification

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.

G Protein-coupled Receptors

G Protein-coupled Receptors
  • Author : Georges Vauquelin,Bengt von Mentzer
  • Publisher : John Wiley & Sons
  • Release Date : 2008-03-11
  • ISBN : 047051664X
GET THIS BOOKG Protein-coupled Receptors

G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology provides a