Fast Facts Glioblastoma

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  • Publisher : Karger Medical and Scientific Publishers
  • Release : 26 February 2020
  • ISBN : 9781912776719
  • Page : 76 pages
  • Rating : 4.5/5 from 103 voters

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Glioblastoma (also known as glioblastoma multiforme) is a malignant intrinsic tumor thought to arise from populations of stem/progenitor cells in the brain. It is the most common aggressive intrinsic brain tumor in adults, with the potential to spread rapidly within the brain. Patients with glioblastoma face a poor prognosis, with median overall survival of approximately 15 months. However, our growing understanding of the molecular biology of gliomas means that this outlook may be improving. The identification of clinically relevant subgroups defined by specific genetic mutations is challenging the traditional delineation between low- and high-grade gliomas that has been based on histological appearance and imaging. Indeed, it is becoming clear that, as a molecular entity, a glioblastoma, which by traditional classification is a grade IV glioma, may present with a lower grade initially and then become more aggressive – an important addition to the established concept. The care of a patient with a glioblastoma requires a coordinated approach delivered by a multidisciplinary team, with the aim of maintaining quality of life for as long as possible. Here, we provide a concise overview of the diagnosis and management of glioblastoma, as well as discussion of our emerging understanding of the molecular drivers that are helping us to delineate different patient subgroups. These subgroups will, hopefully, allow more targeted treatments in the future. This resource will be of interest to all those involved in caring for patients with this aggressive brain tumor, including neurologists, neurosurgeons, neuro-oncologists, radiation oncologists, palliative care specialists, specialist nurses and medical students. Contents: • Epidemiology, pathophysiology and classification • Clinical presentation • Diagnosis • Management • Treatment of associated conditions • Emerging research and treatment

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Fast Facts: Glioblastoma

Fast Facts: Glioblastoma
  • Author : M. McNamara,S. Brandner,S.C. Thust
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2020-02-26
  • ISBN : 9781912776719
GET THIS BOOKFast Facts: Glioblastoma

Glioblastoma (also known as glioblastoma multiforme) is a malignant intrinsic tumor thought to arise from populations of stem/progenitor cells in the brain. It is the most common aggressive intrinsic brain tumor in adults, with the potential to spread rapidly within the brain. Patients with glioblastoma face a poor prognosis, with median overall survival of approximately 15 months. However, our growing understanding of the molecular biology of gliomas means that this outlook may be improving. The identification of clinically relevant subgroups

Glioblastoma:

Glioblastoma:
  • Author : Swapan K. Ray
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-10-31
  • ISBN : 9781441904102
GET THIS BOOKGlioblastoma:

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new

Glioblastoma

Glioblastoma
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2023-02-08
  • ISBN : OCLC:1125677458
GET THIS BOOKGlioblastoma

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies
  • Author : Ramasamy Paulmurugan,Tarik F. Massoud
  • Publisher : Academic Press
  • Release Date : 2021-06-25
  • ISBN : 9780128215685
GET THIS BOOKGlioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists,

Novel Therapeutic Advances in Glioblastoma

Novel Therapeutic Advances in Glioblastoma
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-22
  • ISBN : 9780128211151
GET THIS BOOKNovel Therapeutic Advances in Glioblastoma

Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promising strategies of glioblastoma treatment: personalized genotoxic therapy and stem cell transplantation, Extracellular matrix and biocompatible materials in glioblastoma treatment, Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient, Advanced Multimodal Imaging

Precision Molecular Pathology of Glioblastoma

Precision Molecular Pathology of Glioblastoma
  • Author : José Javier Otero,Aline Paixao Becker
  • Publisher : Springer Nature
  • Release Date : 2021-04-30
  • ISBN : 9783030691707
GET THIS BOOKPrecision Molecular Pathology of Glioblastoma

This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to

Glioblastoma E-Book

Glioblastoma E-Book
  • Author : Steven Brem,Kalil G. Abdullah
  • Publisher : Elsevier Health Sciences
  • Release Date : 2016-09-22
  • ISBN : 9780323479745
GET THIS BOOKGlioblastoma E-Book

Clinically focused and designed to provide a to-the-point overview, Glioblastoma , by Drs. Steven Brem and Kalil G. Abdullah, brings you up to date with increased understanding, new treatment protocols, and recent advances in the field. Written by contributing specialists who are global experts in their respective areas, this one-stop reference provides neurosurgeons, medical-and-radiation oncologists, neuro-oncologists, neuropathologists, internal medicine physicians, and researchers with a dependable source of information on current treatment options, tumor recurrence, and patient care. Evidence for current treatment

A Statistic of One

A Statistic of One
  • Author : Stephen Hatrak
  • Publisher : iUniverse
  • Release Date : 2012-05
  • ISBN : 9781475916348
GET THIS BOOKA Statistic of One

A Statistic of One: My Walk with Glioblastoma Multiforme traces Stephen Hatrak's life from his diagnosis of glioblastoma multiforme, the deadliest of malignant brain tumors, to the present. He chronicles the trials and tribulations he faced and the losses he suffered along his journey. Faith and inner strength are formidable allies in overcoming any tragedy in one's life, and they played vital roles in his struggle. He was told from the start that the he might have twelve months to

Irreversible Electroporation

Irreversible Electroporation
  • Author : Boris Rubinsky
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-11-25
  • ISBN : 9783642054204
GET THIS BOOKIrreversible Electroporation

Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of

Surviving "Terminal" Cancer

Surviving
  • Author : Ben Williams, Ph.D.
  • Publisher : Createspace Independent Pub
  • Release Date : 2002-06-02
  • ISBN : 1477496513
GET THIS BOOKSurviving "Terminal" Cancer

An account of dealing with glioblastoma brain cancer, along with the information needed to survive it

Radiobiology of Glioblastoma

Radiobiology of Glioblastoma
  • Author : Luigi Pirtoli,Giovanni Luca Gravina,Antonio Giordano
  • Publisher : Springer
  • Release Date : 2016-06-06
  • ISBN : 9783319283050
GET THIS BOOKRadiobiology of Glioblastoma

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in

Targeted Therapies for Glioblastoma: A Critical Appraisal

Targeted Therapies for Glioblastoma: A Critical Appraisal
  • Author : Shiv K. Gupta,Sani H. Kizilbash,Thierry M. Muanza
  • Publisher : Frontiers Media SA
  • Release Date : 2020-01-22
  • ISBN : 9782889633531
GET THIS BOOKTargeted Therapies for Glioblastoma: A Critical Appraisal

Advances in Biology and Treatment of Glioblastoma

Advances in Biology and Treatment of Glioblastoma
  • Author : Kumaravel Somasundaram
  • Publisher : Springer
  • Release Date : 2017-06-29
  • ISBN : 9783319568201
GET THIS BOOKAdvances in Biology and Treatment of Glioblastoma

This volume covers the most important areas of glioblastoma – surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.

Glioblastoma, Part I: Surgical Management and Adjuncts, An Issue of Neurosurgery Clinics of North America, E-Book

Glioblastoma, Part I: Surgical Management and Adjuncts, An Issue of Neurosurgery Clinics of North America, E-Book
  • Author : Michael A Vogelbaum
  • Publisher : Elsevier Health Sciences
  • Release Date : 2020-12-04
  • ISBN : 9780323790956
GET THIS BOOKGlioblastoma, Part I: Surgical Management and Adjuncts, An Issue of Neurosurgery Clinics of North America, E-Book

This issue of Neurosurgery Clinics, guest edited by Dr. Michael A. Vogelbaum, is devoted to Glioblastoma, Part I: Surgical Management and Adjuncts. This is one of four issues selected each year by the series Consulting Editors, Russell R. Lonser and Daniel K. Resnick. Articles in this issue include: Perioperative Management of Patients with Glioblastoma, Role of Resection in Glioblastoma Management, Advancing Imaging to Enhance Surgery, Intraoperative Imaging for High-Grade Glioma Surgery, Use of Intraoperative Fluorophores, Extent of Resection of Glioblastoma,

Neural Stem Cells of the Subventricular Zone: from Neurogenesis to Glioblastoma Origin

Neural Stem Cells of the Subventricular Zone: from Neurogenesis to Glioblastoma Origin
  • Author : Esperanza R. Matarredona,Carmen Castro,Hugo Guerrero-Cazares,Natanael Zarco
  • Publisher : Frontiers Media SA
  • Release Date : 2021-11-05
  • ISBN : 9782889715954
GET THIS BOOKNeural Stem Cells of the Subventricular Zone: from Neurogenesis to Glioblastoma Origin