Genome Stability

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  • Publisher : Academic Press
  • Release : 17 July 2021
  • ISBN : 9780323856805
  • Page : 760 pages
  • Rating : 4.5/5 from 103 voters

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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

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Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release Date : 2021-07-17
  • ISBN : 9780323856805
GET THIS BOOKGenome Stability

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release Date : 2013-12-16
  • ISBN : 9781317682318
GET THIS BOOKGenome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-11
  • ISBN : 9048134714
GET THIS BOOKGenome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our

Nuclear Genome Stability: DNA Replication, Telomere Maintenance, and DNA Repair

Nuclear Genome Stability: DNA Replication, Telomere Maintenance, and DNA Repair
  • Author : Maria Isabel Nogueira Cano,Richard McCulloch,Marcelo Santos Da Silva
  • Publisher : Frontiers Media SA
  • Release Date : 2022-03-09
  • ISBN : 9782889746309
GET THIS BOOKNuclear Genome Stability: DNA Replication, Telomere Maintenance, and DNA Repair

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release Date : 2018-01-16
  • ISBN : 9782889453894
GET THIS BOOKMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (

Systems Biology of Cancer

Systems Biology of Cancer
  • Author : Sam Thiagalingam
  • Publisher : Cambridge University Press
  • Release Date : 2015-04-09
  • ISBN : 9780521493390
GET THIS BOOKSystems Biology of Cancer

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

DNA Damage, Genome Stability and Human Disease

DNA Damage, Genome Stability and Human Disease
  • Author : Yuejin Hua,Hari S. Misra,Anthony Davis
  • Publisher : Frontiers Media SA
  • Release Date : 2022-01-27
  • ISBN : 9782889741946
GET THIS BOOKDNA Damage, Genome Stability and Human Disease

Genome Instability in Cancer Development

Genome Instability in Cancer Development
  • Author : Erich A. Nigg
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-14
  • ISBN : 9781402037641
GET THIS BOOKGenome Instability in Cancer Development

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Pub
  • Release Date : 2014
  • ISBN : 0815344856
GET THIS BOOKGenome Stability

"Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination

Roles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination
  • Author : Juan Argueso Almeida
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : CORNELL:31924094621632
GET THIS BOOKRoles for the Saccharomyces Cerevisiae MLH1 Mismatch Repair Gene in Genome Stability and Genetic Recombination

Mismatch repair (MMR) systems correct mismatches formed during DNA replication and genetic recombination and as the result of DNA damage. MMR is initiated by a conserved family of MutS (MSH) and MutL (MLH) homolog proteins. MLH1 is unique among these proteins because it is also required for high levels of crossing over which are necessary for the proper disjunction of homologous chromosomes during the first meiotic division.

Epigenetics and Systems Biology

Epigenetics and Systems Biology
  • Author : Leonie Ringrose
  • Publisher : Academic Press
  • Release Date : 2017-04-25
  • ISBN : 9780128030769
GET THIS BOOKEpigenetics and Systems Biology

Epigenetics and Systems Biology highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies. This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments. Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied.

Somatic Genome Variation

Somatic Genome Variation
  • Author : Xiu-Qing Li
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-26
  • ISBN : 9781118647066
GET THIS BOOKSomatic Genome Variation

Written by an international team of experts, Somatic Genome Variation presents a timely summary of the latest understanding of somatic genome development and variation in plants, animals, and microorganisms. Wide-ranging in coverage, the authors provide an updated view of somatic genomes and genetic theories while also offering interpretations of somatic genome variation. The text provides geneticists, bioinformaticians, biologist, plant scientists, crop scientists, and microbiologists with a valuable overview of this fascinating field of research.

DNA Repair and Replication

DNA Repair and Replication
  • Author : Roger J. A. Grand,John J. Reynolds
  • Publisher : Garland Science
  • Release Date : 2018-09-03
  • ISBN : 9780429876547
GET THIS BOOKDNA Repair and Replication

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Transposons and the Dynamic Genome

Transposons and the Dynamic Genome
  • Author : Dirk-Henner Lankenau,Jean-Nicolas Volff
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-06-30
  • ISBN : 9783642020056
GET THIS BOOKTransposons and the Dynamic Genome

This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life.

Genome and Disease

Genome and Disease
  • Author : Jean-Nicolas Volff
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2006-01-01
  • ISBN : 9783805580298
GET THIS BOOKGenome and Disease

Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several