Genetic Toxicology Testing

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  • Publisher : Academic Press
  • Release : 28 May 2016
  • ISBN : 9780128010068
  • Page : 460 pages
  • Rating : 4.5/5 from 103 voters

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Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

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Genetic Toxicology Testing

Genetic Toxicology Testing
  • Author : Ray Proudlock
  • Publisher : Academic Press
  • Release Date : 2016-05-28
  • ISBN : 9780128010068
GET THIS BOOKGenetic Toxicology Testing

Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in

Genetic Toxicology

Genetic Toxicology
  • Author : James M. Parry,Elizabeth M. Parry
  • Publisher : Humana Press
  • Release Date : 2011-12-07
  • ISBN : 1617794201
GET THIS BOOKGenetic Toxicology

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of

Genotoxicity and Carcinogenicity Testing of Pharmaceuticals

Genotoxicity and Carcinogenicity Testing of Pharmaceuticals
  • Author : Michael J. Graziano,David Jacobson-Kram
  • Publisher : Springer
  • Release Date : 2015-11-02
  • ISBN : 9783319220840
GET THIS BOOKGenotoxicity and Carcinogenicity Testing of Pharmaceuticals

This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emerging tests. With contributions from recognized experts in the pharmaceutical industry and health authorities, this volume presents a balanced view on the interpretation and application

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release Date : 2001-08-31
  • ISBN : 9781135554200
GET THIS BOOKGenetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard ide

OECD Series on Testing and Assessment Overview on genetic toxicology TGs

OECD Series on Testing and Assessment Overview on genetic toxicology TGs
  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 2017-04-13
  • ISBN : 9789264274761
GET THIS BOOKOECD Series on Testing and Assessment Overview on genetic toxicology TGs

Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 478: Rodent Dominant Lethal Test

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 478: Rodent Dominant Lethal Test
  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 2016-07-29
  • ISBN : 9789264264823
GET THIS BOOKOECD Guidelines for the Testing of Chemicals, Section 4 Test No. 478: Rodent Dominant Lethal Test

The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.

Insight on Genotoxicity

Insight on Genotoxicity
  • Author : Shiv Shankar Shukla,Ravindra Kumar Pandey,Bina Gidwani,Gunjan Kalyani
  • Publisher : CRC Press
  • Release Date : 2020-10-14
  • ISBN : 9781000197310
GET THIS BOOKInsight on Genotoxicity

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 1984-04-04
  • ISBN : 9789264071346
GET THIS BOOKOECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...

Principles of Genetic Toxicology

Principles of Genetic Toxicology
  • Author : D. Brusick
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • ISBN : 9781489919809
GET THIS BOOKPrinciples of Genetic Toxicology

The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of

Genotoxicity Assessment

Genotoxicity Assessment
  • Author : Alok Dhawan,Mahima Bajpayee
  • Publisher : Humana Press
  • Release Date : 2013-08-08
  • ISBN : 1627035281
GET THIS BOOKGenotoxicity Assessment

Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of

Genetic Toxicology

Genetic Toxicology
  • Author : Albert P. Li,Robert H. Heflich
  • Publisher : CRC Press
  • Release Date : 1991-03-27
  • ISBN : 0849388155
GET THIS BOOKGenetic Toxicology

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and

Genetic Toxicology Testing

Genetic Toxicology Testing
  • Author : Ray Proudlock
  • Publisher : Academic Press
  • Release Date : 2016-06-01
  • ISBN : 0128007648
GET THIS BOOKGenetic Toxicology Testing

Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory ad test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test
  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 1986-10-23
  • ISBN : 9789264071483
GET THIS BOOKOECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test

The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...

A Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2012-11-02
  • ISBN : 9780123878151
GET THIS BOOKA Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. Intended as a comprehensive resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations (CRO), this book will discuss discovery toxicology and the international guidelines for

The Micronucleus Assay in Toxicology

The Micronucleus Assay in Toxicology
  • Author : Michael Fenech,Siegfried Knasm├╝ller
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-07-18
  • ISBN : 9781788018494
GET THIS BOOKThe Micronucleus Assay in Toxicology

Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods