Fragment Based Drug Discovery

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  • Publisher : Royal Society of Chemistry
  • Release : 03 July 2015
  • ISBN : 9781849739085
  • Page : 314 pages
  • Rating : 4.5/5 from 103 voters

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Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

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Fragment-Based Drug Discovery

Fragment-Based Drug Discovery
  • Author : Steven Howard,Chris Abell
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-07-03
  • ISBN : 9781849739085
GET THIS BOOKFragment-Based Drug Discovery

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug

In-Silico Lead Discovery

In-Silico Lead Discovery
  • Author : Maria A. Miteva
  • Publisher : Bentham Science Publishers
  • Release Date : 2011
  • ISBN : 9781608051427
GET THIS BOOKIn-Silico Lead Discovery

Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinf

Fragment-based Drug Discovery

Fragment-based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • ISBN : 9783527337750
GET THIS BOOKFragment-based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Inhibitors of Molecular Chaperones as Therapeutic Agents

Inhibitors of Molecular Chaperones as Therapeutic Agents
  • Author : Timothy D. Machajewski,Zhenhai Gao,David P. Rotella
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013
  • ISBN : 9781849736664
GET THIS BOOKInhibitors of Molecular Chaperones as Therapeutic Agents

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal

In Silico Methods for Drug Design and Discovery

In Silico Methods for Drug Design and Discovery
  • Author : Simone Brogi,Teodorico Castro Ramalho,José L. Medina-Franco,Kamil Kuca,Marian Valko
  • Publisher : Frontiers Media SA
  • Release Date : 2020-10-09
  • ISBN : 9782889660575
GET THIS BOOKIn Silico Methods for Drug Design and Discovery

Frontiers in Drug Design and Discovery

Frontiers in Drug Design and Discovery
  • Author : Atta-ur- Rahman,Gary W. Caldwell, M. Iqbal Choudhary,Mark R. Player
  • Publisher : Bentham Science Publishers
  • Release Date : 2010-12-13
  • ISBN : 9781608052011
GET THIS BOOKFrontiers in Drug Design and Discovery

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

In Silico Drug Discovery and Design

In Silico Drug Discovery and Design
  • Author : Claudio N. Cavasotto
  • Publisher : CRC Press
  • Release Date : 2015-08-06
  • ISBN : 9781482217858
GET THIS BOOKIn Silico Drug Discovery and Design

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita

Fragment-based Approaches in Drug Discovery

Fragment-based Approaches in Drug Discovery
  • Author : Wolfgang Jahnke,Daniel A. Erlanson
  • Publisher : John Wiley & Sons
  • Release Date : 2006-12-13
  • ISBN : 9783527608607
GET THIS BOOKFragment-based Approaches in Drug Discovery

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design

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  • Author : Om Silakari,Pankaj Kumar Singh
  • Publisher : Academic Press
  • Release Date : 2020-11-05
  • ISBN : 9780128205471
GET THIS BOOKConcepts and Experimental Protocols of Modelling and Informatics in Drug Design

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets.

Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition

Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • ISBN : 9781481688208
GET THIS BOOKGlycogen Synthase Kinases—Advances in Research and Application: 2013 Edition

Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of

Antimicrobials

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  • Author : Flavia Marinelli,Olga Genilloud
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-04
  • ISBN : 9783642399688
GET THIS BOOKAntimicrobials

Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence

The Practice of Medicinal Chemistry

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  • Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
  • Publisher : Elsevier
  • Release Date : 2015-07-01
  • ISBN : 9780124172135
GET THIS BOOKThe Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to

Towards Efficient Designing of Safe Nanomaterials

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  • Author : Jerzy Leszczynski,Tomasz Puzyn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-09-30
  • ISBN : 9781849735476
GET THIS BOOKTowards Efficient Designing of Safe Nanomaterials

The expanding field of nanotechnology is now one of the most promising areas of science. However, because some nanoparticles can have a negative impact on human health and the environment, the design of novel materials must always be accompanied by a comprehensive risk assessment. Until now, the information on the methods available has been fragmented and incomplete. This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical

BioNMR in Drug Research

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  • Author : Oliver Zerbe
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • ISBN : 9783527605422
GET THIS BOOKBioNMR in Drug Research

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the

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  • Author : Debmalya Barh,Muhammad Sarwar Khan,Eric Davies
  • Publisher : Springer
  • Release Date : 2015-03-18
  • ISBN : 9788132221722
GET THIS BOOKPlantOmics: The Omics of Plant Science

PlantOmics: The Omics of Plant Science provides a comprehensive account of the latest trends and developments of omics technologies or approaches and their applications in plant science. Thirty chapters written by 90 experts from 15 countries are included in this state-of-the-art book. Each chapter describes one topic/omics such as: omics in model plants, spectroscopy for plants, next generation sequencing, functional genomics, cyto-metagenomics, epigenomics, miRNAomics, proteomics, metabolomics, glycomics, lipidomics, secretomics, phenomics, cytomics, physiomics, signalomics, thiolomics, organelle omics, micro morphomics, microbiomics, cryobionomics, nanotechnology,