Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

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  • Publisher : Academic Press
  • Release : 24 May 2020
  • ISBN : 9780128199381
  • Page : 240 pages
  • Rating : 4.5/5 from 103 voters

Download Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies in PDF, Epub and Kindle

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

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Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies
  • Author : Chi Hin Cho,Tao Hu
  • Publisher : Academic Press
  • Release Date : 2020-05-24
  • ISBN : 9780128199381
GET THIS BOOKDrug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

Colorectal Cancer

Colorectal Cancer
  • Author : Jindong Chen
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-16
  • ISBN : 9781789231007
GET THIS BOOKColorectal Cancer

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies
  • Author : Chi Hin Cho,Tao Hu
  • Publisher : Academic Press
  • Release Date : 2020-06-22
  • ISBN : 9780128199374
GET THIS BOOKDrug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with

Investigation of Mechanisms of Drug Resistance in Colorectal Cancer

Investigation of Mechanisms of Drug Resistance in Colorectal Cancer
  • Author : M. Ortega Duran
  • Publisher : Unknown
  • Release Date : 2017
  • ISBN : OCLC:1063739318
GET THIS BOOKInvestigation of Mechanisms of Drug Resistance in Colorectal Cancer

Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins

Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins
  • Author : Dennis George
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : OCLC:957491596
GET THIS BOOKNotch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment efforts, tumor recurrence and chemoresistance remain as considerable challenges. Treatment options are limited if surgery and chemotherapy are unsuccessful. Several studies have implicated the Notch signaling pathway in conferring drug resistance to tumor cells, in addition to increased CRC aggressiveness and potential for metastatic spread. Our

Investigating the Evolutionary Dynamics of Drug Resistance in Colorectal Cancer

Investigating the Evolutionary Dynamics of Drug Resistance in Colorectal Cancer
  • Author : Freddie J. H. Whiting
  • Publisher : Unknown
  • Release Date : 2021
  • ISBN : OCLC:1314285445
GET THIS BOOKInvestigating the Evolutionary Dynamics of Drug Resistance in Colorectal Cancer

Identification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer

Identification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer
  • Author : Yang Zang
  • Publisher : Unknown
  • Release Date : 2015
  • ISBN : OCLC:968205469
GET THIS BOOKIdentification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer

Colorectal cancer is the third most common diagnosed and the second leading lethal cancer in the United States. Development of drug resistance is one of the primary causes of colorectal cancer relapse yet underlying mechanisms is still largely unknown and therapeutic treatments remain limited. Here we show that expression of miR-520g/miR-587 is correlated with drug resistance of colon cancer cells. Ectopic expression of miR-520g/miR-587 confers resistance to 5-FU or oxaliplatin-induced apoptosis in vitro and attenuates the

Characterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells

Characterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells
  • Author : Heather Dekker
  • Publisher : Unknown
  • Release Date : 2018
  • ISBN : OCLC:1122755467
GET THIS BOOKCharacterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells

Metastatic colorectal cancer is often fatal, and drug resistance to chemotherapeutic agents is one of the primary contributing factors to this lethality. Drug resistance arises from exposure to chemotherapies, and it can be mediated through a variety of mechanisms. One of these mechanisms is alteration of enzymes within the cancer cells to affect the processing or removal of the drug. Carboxylesterase is an example of an enzyme that converts irinotecan, a drug used in metastatic colorectal cancer treatments, into the

Combination Therapy as a Promising Strategy to Overcome Drug Resistance in Colorectal Cancer

Combination Therapy as a Promising Strategy to Overcome Drug Resistance in Colorectal Cancer
  • Author : Benardina Ndreshkjana
  • Publisher : Unknown
  • Release Date : 2019
  • ISBN : OCLC:1155524899
GET THIS BOOKCombination Therapy as a Promising Strategy to Overcome Drug Resistance in Colorectal Cancer

Multi-Drug Resistance in Cancer

Multi-Drug Resistance in Cancer
  • Author : Jun Zhou
  • Publisher : Humana Press
  • Release Date : 2012-08-09
  • ISBN : 1617796646
GET THIS BOOKMulti-Drug Resistance in Cancer

Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive

Chemo-resistance in Gastrointestinal Cancers

Chemo-resistance in Gastrointestinal Cancers
  • Author : Xia Li,Dong-Hua Yang,Prathibha Ranganathan
  • Publisher : Frontiers Media SA
  • Release Date : 2022-03-30
  • ISBN : 9782889747764
GET THIS BOOKChemo-resistance in Gastrointestinal Cancers

Colon Cancer Diagnosis and Therapy

Colon Cancer Diagnosis and Therapy
  • Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
  • Publisher : Springer Nature
  • Release Date : 2021
  • ISBN : 9783030633691
GET THIS BOOKColon Cancer Diagnosis and Therapy

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the

Drug Transporters in Drug Disposition, Effects and Toxicity

Drug Transporters in Drug Disposition, Effects and Toxicity
  • Author : Xiaodong Liu,Guoyu Pan
  • Publisher : Springer Nature
  • Release Date : 2019-09-30
  • ISBN : 9789811376474
GET THIS BOOKDrug Transporters in Drug Disposition, Effects and Toxicity

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell

Mathematical Modeling of Drug Resistance Due to KRAS Mutation in Colorectal Cancer

Mathematical Modeling of Drug Resistance Due to KRAS Mutation in Colorectal Cancer
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : OCLC:1052078385
GET THIS BOOKMathematical Modeling of Drug Resistance Due to KRAS Mutation in Colorectal Cancer

Cancer Drug Resistance

Cancer Drug Resistance
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-09
  • ISBN : 9781597450355
GET THIS BOOKCancer Drug Resistance

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies,