Drug Metabolism in Diseases

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  • Publisher : Academic Press
  • Release : 12 September 2016
  • ISBN : 9780128029633
  • Page : 294 pages
  • Rating : 4.5/5 from 103 voters

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Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

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Drug Metabolism in Diseases

Drug Metabolism in Diseases
  • Author : Wen Xie
  • Publisher : Academic Press
  • Release Date : 2016-09-12
  • ISBN : 9780128029633
GET THIS BOOKDrug Metabolism in Diseases

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and

Drug Metabolism in Diseases

Drug Metabolism in Diseases
  • Author : Wen Xie
  • Publisher : Academic Press
  • Release Date : 2016-10-03
  • ISBN : 0128029498
GET THIS BOOKDrug Metabolism in Diseases

"Drug Metabolism in Diseases" is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and

Rational Therapeutics for Infants and Children

Rational Therapeutics for Infants and Children
  • Author : Institute of Medicine,Division of Health Sciences Policy,Roundtable on Research and Development of Drugs, Biologics, and Medical Devices,Jonathan R. Davis,Sarah Pitluck,Peter Bouxsein,Ronald W. Estabrook
  • Publisher : National Academies Press
  • Release Date : 2000-04-07
  • ISBN : 0309183642
GET THIS BOOKRational Therapeutics for Infants and Children

The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be

Drugs and the Liver

Drugs and the Liver
  • Author : Penny North-Lewis
  • Publisher : Unknown
  • Release Date : 2008
  • ISBN : UOM:39015073936794
GET THIS BOOKDrugs and the Liver

Liver disease is a widespread and increasing problem throughout the world, however little is published on how different types and degrees of liver dysfunction affect the body's ability to handle medicines."Drugs and the Liver" is designed to assist practitioners in making pragmatic choices for their patients. It aims to: enable the practitioner to assess liver function using biochemical markers, other tests, signs, symptoms and disease knowledge; identify which pharmacokinetic and pharmacodynamic parameters of a drug are likely to be

Introduction to Drug Metabolism

Introduction to Drug Metabolism
  • Author : G. Gordon Gibson,Paul Skett
  • Publisher : Nelson Thornes
  • Release Date : 2001
  • ISBN : 0748760113
GET THIS BOOKIntroduction to Drug Metabolism

Of drug-metabolising reactions. p. 25.

Surgical Procedures on the Cirrhotic Patient

Surgical Procedures on the Cirrhotic Patient
  • Author : Bijan Eghtesad,John Fung
  • Publisher : Springer
  • Release Date : 2017-04-27
  • ISBN : 9783319523965
GET THIS BOOKSurgical Procedures on the Cirrhotic Patient

This volume provides a concise yet comprehensive overview on surgical procedures performed on the cirrhotic patient. The text explains the underlying pathophysiologic alterations in liver disease and cirrhosis, provides assessment of disease severity and risk factors, and helps to predict potential outcomes based on the nature of the operation. Operations discussed in detail include bariatric surgery, colorectal surgery, hepatic surgery, kidney transplantation, gynecological procedures, neurosurgical procedures, and ophthalmic surgery. The book is also supplemented with instructive color illustrations and tables.

Biological Reactive Intermediates IV

Biological Reactive Intermediates IV
  • Author : Charlotte M. Witmer,Robert R. Snyder,David J. Jollow,George F. Kalf,James J. Kocsis
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-09
  • ISBN : 9781468458770
GET THIS BOOKBiological Reactive Intermediates IV

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
  • Author : Aparajita Dey
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-02-12
  • ISBN : 9789400758810
GET THIS BOOKCytochrome P450 2E1: Its Role in Disease and Drug Metabolism

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic

Biochemistry of Drug Metabolizing Enzymes

Biochemistry of Drug Metabolizing Enzymes
  • Author : Muhammad Sajid Hamid Akash,Kanwal Rehman
  • Publisher : Academic Press
  • Release Date : 2022-05-28
  • ISBN : 9780323951210
GET THIS BOOKBiochemistry of Drug Metabolizing Enzymes

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their

Atkinson's Principles of Clinical Pharmacology

Atkinson's Principles of Clinical Pharmacology
  • Author : Shiew-Mei Huang,Juan J.L. Lertora,Paolo Vicini,Arthur J. Atkinson, Jr.
  • Publisher : Academic Press
  • Release Date : 2021-10-16
  • ISBN : 9780128198841
GET THIS BOOKAtkinson's Principles of Clinical Pharmacology

Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with

Metabolism of Human Diseases

Metabolism of Human Diseases
  • Author : Eckhard Lammert,Martin Zeeb
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-06-02
  • ISBN : 9783709107157
GET THIS BOOKMetabolism of Human Diseases

“Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell

Drug Metabolism, Pharmacokinetics and Bioanalysis

Drug Metabolism, Pharmacokinetics and Bioanalysis
  • Author : Hye Suk Lee,Kwang-Hyeon Liu
  • Publisher : MDPI
  • Release Date : 2019-06-12
  • ISBN : 9783038979166
GET THIS BOOKDrug Metabolism, Pharmacokinetics and Bioanalysis

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There

Cytochrome P450 2e1: Its Role in Disease and Drug Metabolism

Cytochrome P450 2e1: Its Role in Disease and Drug Metabolism
  • Author : Aparajita Dey
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-02-04
  • ISBN : 9401782024
GET THIS BOOKCytochrome P450 2e1: Its Role in Disease and Drug Metabolism

Nuclear Receptors in Drug Metabolism

Nuclear Receptors in Drug Metabolism
  • Author : Wen Xie
  • Publisher : John Wiley & Sons
  • Release Date : 2008-11-03
  • ISBN : 9780470409053
GET THIS BOOKNuclear Receptors in Drug Metabolism

This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.

Metabolic Syndrome

Metabolic Syndrome
  • Author : Minghan Wang
  • Publisher : John Wiley & Sons
  • Release Date : 2011-04-18
  • ISBN : 9780470922712
GET THIS BOOKMetabolic Syndrome

METABOLIC SYNDROME A comprehensive look at the fight against the metabolic syndrome epidemic Increasing risk of cardiovascular disease and diabetes, the metabolic syndrome is a world health problem that demands attention from all levels of the health care industry. Metabolic Syndrome: Underlying Mechanisms and Drug therapies extensively covers the metabolic syndrome with an emphasis on drug discovery efforts, providing a context of molecular mechanisms and drug pharmacology for pharmaceutical scientists. The book starts by examining the physiology of metabolic tissues