Drug Discovery in Cancer Epigenetics

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Read or download book entitled Drug Discovery in Cancer Epigenetics written by Gerda Egger and published by Academic Press in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that Drug Discovery in Cancer Epigenetics book is available in the library.

  • Publisher : Academic Press
  • Release : 19 November 2015
  • ISBN : 9780128024928
  • Page : 498 pages
  • Rating : 4.5/5 from 103 voters

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Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

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Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release Date : 2015-11-19
  • ISBN : 9780128024928
GET THIS BOOKDrug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics
  • Author : Gerda Egger,Paola Arimondo
  • Publisher : Academic Press
  • Release Date : 2015-12-16
  • ISBN : 0128022086
GET THIS BOOKDrug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin

Epigenetics for Drug Discovery

Epigenetics for Drug Discovery
  • Author : Nessa Carey
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • ISBN : 9781782628484
GET THIS BOOKEpigenetics for Drug Discovery

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big

Epigenetics for Drug Discovery

Epigenetics for Drug Discovery
  • Author : Nessa Carey
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • ISBN : 9781849738828
GET THIS BOOKEpigenetics for Drug Discovery

This book will provide an invaluable guide to epigenetics, one of the fastest moving fields in drug discovery, for medicinal chemists working in academia and in the pharmaceutical industry.

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy
  • Author : Steven Gray
  • Publisher : Academic Press
  • Release Date : 2015-07-01
  • ISBN : 9780128002247
GET THIS BOOKEpigenetic Cancer Therapy

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

Epigenetic Drug Discovery

Epigenetic Drug Discovery
  • Author : Wolfgang Sippl,Manfred Jung
  • Publisher : John Wiley & Sons
  • Release Date : 2019-03-25
  • ISBN : 9783527343140
GET THIS BOOKEpigenetic Drug Discovery

This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and

Epigenetics in Precision Medicine

Epigenetics in Precision Medicine
  • Author : Jose Luis Garcia-Gimenez
  • Publisher : Elsevier
  • Release Date : 2021-11-22
  • ISBN : 9780323858052
GET THIS BOOKEpigenetics in Precision Medicine

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic

Epigenetics in Cancer: Mechanisms and Drug Development

Epigenetics in Cancer: Mechanisms and Drug Development
  • Author : Xiao Zhu,Biaoru Li,Zhenhua Xu
  • Publisher : Frontiers Media SA
  • Release Date : 2022-07-25
  • ISBN : 9782889743766
GET THIS BOOKEpigenetics in Cancer: Mechanisms and Drug Development

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
  • Author : Jean-Paul Renaud
  • Publisher : John Wiley & Sons
  • Release Date : 2020-01-09
  • ISBN : 9781118900505
GET THIS BOOKStructural Biology in Drug Discovery

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable

The Epigenetics Revolution

The Epigenetics Revolution
  • Author : Nessa Carey
  • Publisher : Columbia University Press
  • Release Date : 2012-03-06
  • ISBN : 9780231530712
GET THIS BOOKThe Epigenetics Revolution

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the

Histone Mutations and Cancer

Histone Mutations and Cancer
  • Author : Dong Fang,Junhong Han
  • Publisher : Springer Nature
  • Release Date : 2020-11-06
  • ISBN : 9789811581045
GET THIS BOOKHistone Mutations and Cancer

This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Elsevier
  • Release Date : 2014-05-02
  • ISBN : 9780124059221
GET THIS BOOKTransgenerational Epigenetics

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms

Pharmacoepigenetics

Pharmacoepigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-04
  • ISBN : 9780128139400
GET THIS BOOKPharmacoepigenetics

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
  • Author : José Luis García-Giménez
  • Publisher : Academic Press
  • Release Date : 2015-12-07
  • ISBN : 9780128019214
GET THIS BOOKEpigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
  • Author : Alexey Moskalev,Alexander M. Vaiserman
  • Publisher : Academic Press
  • Release Date : 2017-11-17
  • ISBN : 9780128110836
GET THIS BOOKEpigenetics of Aging and Longevity

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in