Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

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  • Publisher : Academic Press
  • Release : 20 September 2016
  • ISBN : 9780128028117
  • Page : 316 pages
  • Rating : 4.5/5 from 103 voters

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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release Date : 2016-09-20
  • ISBN : 9780128028117
GET THIS BOOKDrug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies,

Drug Repositioning

Drug Repositioning
  • Author : Joel Dudley,Laura Berliocchi
  • Publisher : CRC Press
  • Release Date : 2017-07-14
  • ISBN : 9781315356211
GET THIS BOOKDrug Repositioning

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches

Neurobiology of Huntington’s Disease

Neurobiology of Huntington’s Disease
  • Author : Donald C. Lo,Robert E. Hughes
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • ISBN : 9781420008258
GET THIS BOOKNeurobiology of Huntington’s Disease

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding

Principles of Neurochemistry

Principles of Neurochemistry
  • Author : Bijo Mathew,Della Grace Thomas Parambi
  • Publisher : Springer Nature
  • Release Date : 2020-09-21
  • ISBN : 9789811551673
GET THIS BOOKPrinciples of Neurochemistry

This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research.

Alzheimer's Disease Drug Development

Alzheimer's Disease Drug Development
  • Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • ISBN : 9781108838665
GET THIS BOOKAlzheimer's Disease Drug Development

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Drug Delivery to the Brain

Drug Delivery to the Brain
  • Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-03
  • ISBN : 9781461491057
GET THIS BOOKDrug Delivery to the Brain

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics

Pharmacogenomics in Drug Discovery and Development

Pharmacogenomics in Drug Discovery and Development
  • Author : Qing Yan
  • Publisher : Springer Nature
  • Release Date : 2022-10-08
  • ISBN : 9781071625736
GET THIS BOOKPharmacogenomics in Drug Discovery and Development

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics

Therapies for Retinal Degeneration

Therapies for Retinal Degeneration
  • Author : de la Rosa (Enrique J.),Thomas G. Cotter
  • Publisher : Royal Society of Chemistry
  • Release Date : 2018
  • ISBN : 9781782629498
GET THIS BOOKTherapies for Retinal Degeneration

This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders
  • Author : Preetham Elumalai,Sreeja Lakshmi
  • Publisher : Springer Nature
  • Release Date : 2022
  • ISBN : 9789811667039
GET THIS BOOKFunctional Foods and Therapeutic Strategies for Neurodegenerative Disorders

This book provides a comprehensive summary of the latest knowledge regarding functional foods and new therapeutic strategies for neurodegenerative disorders through explaining specific mechanisms for natural remedies and functional foods as well as alternative treatment and supplementary approaches for neurodegenerative diseases. Many relevant topics are covered, including role of prebiotics, recent applications for dietary polyphenols, marine bioactive compounds for neuro disorders, and age-related disorders. The roles of various remedies and functional foods are explained for various types of diseases, and

Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10

Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10
  • Author : Atta-ur-Rahman,Zareen Amtul
  • Publisher : Bentham Science Publishers
  • Release Date : 2022-04-07
  • ISBN : 9789815040685
GET THIS BOOKFrontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release Date : 2017-04-05
  • ISBN : 9780081011188
GET THIS BOOKDesign of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of

Neurobiology of Huntington’s Disease

Neurobiology of Huntington’s Disease
  • Author : Donald C. Lo,Robert E. Hughes
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • ISBN : 0849390001
GET THIS BOOKNeurobiology of Huntington’s Disease

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding

Animal Models for Neurodegenerative Disease

Animal Models for Neurodegenerative Disease
  • Author : Jesus Avila,Jose J. Lucas,Felix Hernandez
  • Publisher : Royal Society of Chemistry
  • Release Date : 2011
  • ISBN : 9781849731843
GET THIS BOOKAnimal Models for Neurodegenerative Disease

This book provides up-to-date information on the use of transgenic mouse models in the study of neurodegenerative disorders. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates and academics.

Drug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease
  • Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
  • Publisher : Elsevier
  • Release Date : 2015-06-27
  • ISBN : 9780128039601
GET THIS BOOKDrug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery.

Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery
  • Author : Atta-ur- Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release Date : 2017-12-19
  • ISBN : 9781681084435
GET THIS BOOKFrontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery is a book series devoted to publishing reviews which highlight the latest advances in drug design and discovery for disorders of the central nervous system (CNS). Eminent scientists write contributions on all areas of CNS drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series is essential reading for all pharmaceutical scientists involved in CNS drug design and discovery