Developing Therapeutics for Alzheimer s Disease

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Read or download book entitled Developing Therapeutics for Alzheimer s Disease written by Michael S. Wolfe and published by Academic Press in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that Developing Therapeutics for Alzheimer s Disease book is available in the library.

  • Publisher : Academic Press
  • Release : 27 May 2016
  • ISBN : 9780128021644
  • Page : 676 pages
  • Rating : 4.5/5 from 103 voters

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Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

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Developing Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2016-05-27
  • ISBN : 9780128021644
GET THIS BOOKDeveloping Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the

Alzheimer's Disease Drug Development

Alzheimer's Disease Drug Development
  • Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • ISBN : 9781108838665
GET THIS BOOKAlzheimer's Disease Drug Development

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Alzheimer’s Disease Theranostics

Alzheimer’s Disease Theranostics
  • Author : Magisetty Obulesu
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • ISBN : 9780128167397
GET THIS BOOKAlzheimer’s Disease Theranostics

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders

Global Clinical Trials for Alzheimer's Disease

Global Clinical Trials for Alzheimer's Disease
  • Author : Menghis Bairu,Michael Weiner
  • Publisher : Academic Press
  • Release Date : 2013-08-28
  • ISBN : 9780124115309
GET THIS BOOKGlobal Clinical Trials for Alzheimer's Disease

Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in

Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease
  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • ISBN : 9780128037126
GET THIS BOOKNeuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is

Alzheimer's Disease

Alzheimer's Disease
  • Author : Renee D. Wegrzyn,Alan S. Rudolph
  • Publisher : CRC Press
  • Release Date : 2012-04-26
  • ISBN : 9781439827093
GET THIS BOOKAlzheimer's Disease

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from

Biomarkers in Alzheimer's Disease

Biomarkers in Alzheimer's Disease
  • Author : Tapan Khan
  • Publisher : Academic Press
  • Release Date : 2016-08-02
  • ISBN : 9780128051474
GET THIS BOOKBiomarkers in Alzheimer's Disease

Biomarkers in Alzheimer’s Disease provides a comprehensive overview of all modalities of Alzheimer’s disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer’s disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer’s disease, and for differential diagnosis of Alzheimer’

Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy

Alzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy
  • Author : M.C. Carrillo,H. Hampel
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2012-04-23
  • ISBN : 9783805598033
GET THIS BOOKAlzheimer's Disease - Modernizing Concept, Biological Diagnosis and Therapy

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on

The Alzheimer's Disease Challenge

The Alzheimer's Disease Challenge
  • Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
  • Publisher : Frontiers Media SA
  • Release Date : 2019-12-04
  • ISBN : 9782889631285
GET THIS BOOKThe Alzheimer's Disease Challenge

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population

Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease

Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease
  • Author : Ghulam Md Ashraf,Athanasios Alexiou
  • Publisher : Springer Nature
  • Release Date : 2019-10-11
  • ISBN : 9789811396366
GET THIS BOOKBiological, Diagnostic and Therapeutic Advances in Alzheimer's Disease

This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers

Current State of Alzheimer's Disease Research and Therapeutics

Current State of Alzheimer's Disease Research and Therapeutics
  • Author : Mary Lou Michaelis,Elias K. Michaelis
  • Publisher : Academic Press
  • Release Date : 2012-08-02
  • ISBN : 9780123948168
GET THIS BOOKCurrent State of Alzheimer's Disease Research and Therapeutics

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Uday Kishore
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-15
  • ISBN : 9789535110880
GET THIS BOOKNeurodegenerative Diseases

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Nagehan Ersoy Tunalı
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-01-20
  • ISBN : 9781838801496
GET THIS BOOKNeurodegenerative Diseases

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical

Geriatric Medicine and Gerontology

Geriatric Medicine and Gerontology
  • Author : Edward T. Jr Zawada
  • Publisher : Unknown
  • Release Date : 2019
  • ISBN : 1789841445
GET THIS BOOKGeriatric Medicine and Gerontology

This volume is a collection of reports dealing with geriatrics and gerontology. The first section provides an introduction to the common medical and non-medical problems of aging. The second section concentrates on one of the most devastating problems of the elderly, that of dementia. Finally, the third section deals with newer topics such as hearing loss, acute and chronic lymphoproliferative disorders, and the use of nerve and muscle stimulation to reduce morbidity and mortality associated with degenerative neurologic diseases. The

Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience
  • Author : Jerry J. Buccafusco
  • Publisher : CRC Press
  • Release Date : 2000-08-29
  • ISBN : 9781420041811
GET THIS BOOKMethods of Behavior Analysis in Neuroscience

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic