Computer Aided Applications in Pharmaceutical Technology

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  • Publisher : Elsevier
  • Release : 10 April 2013
  • ISBN : 9781908818324
  • Page : 300 pages
  • Rating : 4.5/5 from 103 voters

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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

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Computer-Aided Applications in Pharmaceutical Technology

Computer-Aided Applications in Pharmaceutical Technology
  • Author : Jelena Djuris
  • Publisher : Elsevier
  • Release Date : 2013-04-10
  • ISBN : 9781908818324
GET THIS BOOKComputer-Aided Applications in Pharmaceutical Technology

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
  • Author : Ivana Masic,Jelena Parojcic,Zorica Djuric
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-04-10
  • ISBN : 9780128091937
GET THIS BOOKComputer-aided applications in pharmaceutical technology

This chapter introduces the concept of computational fluid dynamics (CFD) and its applications in pharmaceutical technology. Basic theoretical explanations on the mathematics of fluid flow and numerical grids are provided. CFD is a versatile tool that is mainly used in complex dynamical process characterization. Examples of CFD applications in development of inhalers, analysis of dissolution apparatus hydrodynamics, and fluidized bed process simulations are presented.

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
  • Author : Ljiljana Djekic,Dragana Vasiljevic,Marija Primorac
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-04-10
  • ISBN : 9780128091883
GET THIS BOOKComputer-aided applications in pharmaceutical technology

This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
  • Author : Sandra Grbic,Jelena Parojcic,Zorica Djuric
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-04-10
  • ISBN : 9780128091920
GET THIS BOOKComputer-aided applications in pharmaceutical technology

This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.

Computer-aided applications in pharmaceutical technology

Computer-aided applications in pharmaceutical technology
  • Author : Jelena Djuris,Svetlana Ibric,Zorica Djuric
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-04-10
  • ISBN : 9780128091890
GET THIS BOOKComputer-aided applications in pharmaceutical technology

This chapter provides a basic theoretical background on experimental design application and interpretation. Techniques described include screening designs, full and fractional factorial designs, Plackett–Burman design, D-optimal designs, response surface methodology, central composite designs, Box–Behnken design, and mixture designs, etc. The reader will be introduced to the experimental domains covered by specific design, making it easier to select the one appropriate for the problem. After theoretical introduction, a number of illustrative examples of design of experiments application in the

Computer Aided Pharmaceutics and Drug Delivery

Computer Aided Pharmaceutics and Drug Delivery
  • Author : Vikas Anand Saharan
  • Publisher : Springer Nature
  • Release Date : 2022-05-30
  • ISBN : 9789811651809
GET THIS BOOKComputer Aided Pharmaceutics and Drug Delivery

This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems.

Computer-Aided Vaccine Design

Computer-Aided Vaccine Design
  • Author : Joo Chuan Tong,Shoba Ranganathan
  • Publisher : Elsevier
  • Release Date : 2013-07-31
  • ISBN : 9781908818416
GET THIS BOOKComputer-Aided Vaccine Design

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used,

An Introduction to Pharmaceutical Sciences

An Introduction to Pharmaceutical Sciences
  • Author : Jiben Roy
  • Publisher : Elsevier
  • Release Date : 2011-07-25
  • ISBN : 9781908818041
GET THIS BOOKAn Introduction to Pharmaceutical Sciences

This textbook is written as a unified approach to various topics, ranging from drug discovery to manufacturing, techniques and technology, regulation and marketing. The key theme of the book is pharmaceuticals - what every student of pharmaceutical sciences should know: from the active pharmaceutical ingredients to the preparation of various dosage forms along with the relevant chemistry, this book makes pharmaceuticals relevant to undergraduate students of pharmacy and pharmaceutical sciences. This book explains how a particular drug was discovered and

Novel Platforms for Drug Delivery Applications

Novel Platforms for Drug Delivery Applications
  • Author : Sangita Das,Sabu Thomas,Partha Pratim Das
  • Publisher : Woodhead Publishing
  • Release Date : 2022-11-18
  • ISBN : 9780323913782
GET THIS BOOKNovel Platforms for Drug Delivery Applications

Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ?-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety

Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals

Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals
  • Author : Tim Sandle
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • ISBN : 9781908818638
GET THIS BOOKSterility, Sterilisation and Sterility Assurance for Pharmaceuticals

Failure to adequately control any microbial challenge associated within process or product by robust sterilisation will result in a contaminated marketed product, with potential harm to the patient. Sterilisation is therefore of great importance to healthcare and the manufacturers of medical devices and pharmaceuticals. Sterility, sterilisation and sterility assurance for pharmaceuticals examines different means of rendering a product sterile by providing an overview of sterilisation methods including heat, radiation and filtration. The book outlines and discusses sterilisation technology and the

Bioinformatics for Biomedical Science and Clinical Applications

Bioinformatics for Biomedical Science and Clinical Applications
  • Author : K-H Liang
  • Publisher : Elsevier
  • Release Date : 2013-07-31
  • ISBN : 9781908818232
GET THIS BOOKBioinformatics for Biomedical Science and Clinical Applications

Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications. Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical

Formulation tools for Pharmaceutical Development

Formulation tools for Pharmaceutical Development
  • Author : J E Aguilar
  • Publisher : Elsevier
  • Release Date : 2013-09-30
  • ISBN : 9781908818508
GET THIS BOOKFormulation tools for Pharmaceutical Development

A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools. Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_

Commercializing the Stem Cell Sciences

Commercializing the Stem Cell Sciences
  • Author : Olivia Harvey
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • ISBN : 9781908818140
GET THIS BOOKCommercializing the Stem Cell Sciences

Promising new developments in biomedical technology such as stem cell science are widely endorsed by governments keen to reduce spiralling healthcare costs, clinicians focused on patient care, and patients demanding revolutionary new treatments. Commercializing the stem cell sciences offers a comparative analysis of the commercial methods adopted in the global stem cell industries. It seeks to establish whether there is an optimum commercial model and to examine what emerging companies can learn from their predecessors. Following an introduction to stem

Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs
  • Author : Bojan Čalija
  • Publisher : Academic Press
  • Release Date : 2017-01-03
  • ISBN : 9780128040805
GET THIS BOOKMicrosized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs

Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin. This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal,

Computer Applications in Pharmaceutical Research and Development

Computer Applications in Pharmaceutical Research and Development
  • Author : Sean Ekins
  • Publisher : John Wiley & Sons
  • Release Date : 2006-07-11
  • ISBN : 9780470037225
GET THIS BOOKComputer Applications in Pharmaceutical Research and Development

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view,