Computational Toxicology

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  • Publisher : John Wiley & Sons
  • Release : 13 February 2018
  • ISBN : 9781119282563
  • Page : 450 pages
  • Rating : 4.5/5 from 103 voters

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A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is currently achievable with computational toxicology and a view to future developments Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

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Computational Toxicology

Computational Toxicology
  • Author : Sean Ekins
  • Publisher : John Wiley & Sons
  • Release Date : 2018-02-13
  • ISBN : 9781119282563
GET THIS BOOKComputational Toxicology

A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is currently achievable with computational toxicology and a view to future developments Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment Assembles cutting-edge concepts and leading authors into a unique

Computational Toxicology

Computational Toxicology
  • Author : Sean Ekins
  • Publisher : John Wiley & Sons
  • Release Date : 2007-06-30
  • ISBN : 9780470145883
GET THIS BOOKComputational Toxicology

A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing

Computational Toxicology

Computational Toxicology
  • Author : William Mendez,Bruce A. Fowler
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • ISBN : 9780128060537
GET THIS BOOKComputational Toxicology

The focus of the chapter is on the development and application of computational toxicology methods to human risk assessment. The various CompTox methods are defined, and a brief history of their development and applications in risk assessment is provided. The technological, economic, and public health concerns driving the development of the methods are described, along with how the specific forces shaped the historical and current use of CompTox methods in risk assessment. Translation research programs in the United States and

Computational Toxicology

Computational Toxicology
  • Author : Luis G. Valerio
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • ISBN : 9780128060476
GET THIS BOOKComputational Toxicology

The remarkable advances of high-performance computing to facilitate and increase efficiency in helping to resolve or support assessments on the toxic effects of chemicals on tissues and genomic material have led to development of novel in silico methods. These methods can support risk assessment via integration of study data that can be translated into meaningful predictive information. This chapter describes some methods in computational toxicology and how to integrate experimental data with computational assessments for supporting risk assessment.

Computational Toxicology

Computational Toxicology
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release Date : 2013-06-04
  • ISBN : 9780123965080
GET THIS BOOKComputational Toxicology

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided

Computational Toxicology

Computational Toxicology
  • Author : Isaac Warren,Eftim Sorina
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • ISBN : 9780128060506
GET THIS BOOKComputational Toxicology

New and emerging high-throughput toxicology and human exposure data sets offer great promise to expand or reshape the process of chemical risk assessment. While the methods to mine new computational toxicology data and assess its predictive power and compatibility with more traditional toxicology data are still under development, this chapter presents publicly available data sets that can be mined to support risk assessment. Risk assessors are faced with adapting to toxicity testing in the 21st century and soon may be

Computational Toxicology

Computational Toxicology
  • Author : Nigel Greene,Mark Gosink
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • ISBN : 9780128060513
GET THIS BOOKComputational Toxicology

The costs of developing new drugs continue to rise while public and governmental expectations demand safer drugs. This demand for safer drugs can also significantly delay the time it takes to reach the market, as screening for drug safety can be a time-consuming process. In order to reduce costs and timelines while increasing safety, pharmaceutical firms have incorporated predictive methodologies to identify potential safety issues before a new drug is given to patients or even before a compound is tested

Advances in Computational Toxicology

Advances in Computational Toxicology
  • Author : Huixiao Hong
  • Publisher : Springer
  • Release Date : 2019-05-21
  • ISBN : 9783030164430
GET THIS BOOKAdvances in Computational Toxicology

This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
  • Author : Rudy J Richardson,Dale E Johnson
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-03-03
  • ISBN : 9781782623328
GET THIS BOOKComputational Systems Pharmacology and Toxicology

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.

Chemometrics and Cheminformatics in Aquatic Toxicology

Chemometrics and Cheminformatics in Aquatic Toxicology
  • Author : Kunal Roy
  • Publisher : John Wiley & Sons
  • Release Date : 2022-01-06
  • ISBN : 9781119681595
GET THIS BOOKChemometrics and Cheminformatics in Aquatic Toxicology

CHEMOMETRICS AND CHEMINFORMATICS IN AQUATIC TOXICOLOGY Explore chemometric and cheminformatic techniques and tools in aquatic toxicology Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various

In Silico Toxicology

In Silico Toxicology
  • Author : Mark T. D. Cronin,Judith C. Madden
  • Publisher : Royal Society of Chemistry
  • Release Date : 2010
  • ISBN : 9781849730044
GET THIS BOOKIn Silico Toxicology

In silico methods to predict toxicity are becoming increasingly important, particularly in light of European legislation such as Reach and the Cosmetics Regulation. They are also being used extensively worldwide e.g. in the USA, Canada, Japan and Australia. The objective of In Silico Toxicology: Principles and Applications is to enable the reader to develop new, and use existing, in silico methods to predict the toxicity and fate of chemicals. It develops the theme in a logical sequence leading the

Comprehensive Toxicology

Comprehensive Toxicology
  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2017-12-01
  • ISBN : 9780081006122
GET THIS BOOKComprehensive Toxicology

Comprehensive Toxicology, Third Edition, discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • ISBN : 9780128137253
GET THIS BOOKInformation Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • ISBN : 9781464967085
GET THIS BOOKIssues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Drug Management, Toxicology, Monitoring, Resistance, and Safety. The editors have built Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drug Management, Toxicology, Monitoring, Resistance, and Safety in this eBook to be deeper than what you can access anywhere else, as well as consistently

Hayes' Principles and Methods of Toxicology

Hayes' Principles and Methods of Toxicology
  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release Date : 2014-10-10
  • ISBN : 9781842145371
GET THIS BOOKHayes' Principles and Methods of Toxicology

Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap