Computational Systems Biology

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  • Publisher : Academic Press
  • Release : 26 November 2013
  • ISBN : 9780124059382
  • Page : 548 pages
  • Rating : 4.5/5 from 103 voters

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This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

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Computational Systems Biology

Computational Systems Biology
  • Author : Andres Kriete,Roland Eils
  • Publisher : Academic Press
  • Release Date : 2013-11-26
  • ISBN : 9780124059382
GET THIS BOOKComputational Systems Biology

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational

An Introduction to Computational Systems Biology

An Introduction to Computational Systems Biology
  • Author : Karthik Raman
  • Publisher : CRC Press
  • Release Date : 2021-05-30
  • ISBN : 9780429944529
GET THIS BOOKAn Introduction to Computational Systems Biology

This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable

Computational Systems Biology of Cancer

Computational Systems Biology of Cancer
  • Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
  • Publisher : CRC Press
  • Release Date : 2012-08-25
  • ISBN : 9781439831441
GET THIS BOOKComputational Systems Biology of Cancer

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the

Learning and Inference in Computational Systems Biology

Learning and Inference in Computational Systems Biology
  • Author : Neil D. Lawrence,Guido Sanguinetti,Magnus Rattray,Mark Girolami
  • Publisher : Mit Press
  • Release Date : 2010
  • ISBN : STANFORD:36105215298956
GET THIS BOOKLearning and Inference in Computational Systems Biology

Tools and techniques for biological inference problems at scales ranging from genome-wide to pathway-specific. Computational systems biology unifies the mechanistic approach of systems biology with the data-driven approach of computational biology. Computational systems biology aims to develop algorithms that uncover the structure and parameterization of the underlying mechanistic model--in other words, to answer specific questions about the underlying mechanisms of a biological system--in a process that can be thought of as learning or inference. This volume offers state-of-the-art perspectives from

Frontiers in Computational and Systems Biology

Frontiers in Computational and Systems Biology
  • Author : Jianfeng Feng,Wenjiang Fu,Fengzhu Sun
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-06-14
  • ISBN : 9781849961967
GET THIS BOOKFrontiers in Computational and Systems Biology

Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such

Integer Linear Programming in Computational and Systems Biology

Integer Linear Programming in Computational and Systems Biology
  • Author : Dan Gusfield
  • Publisher : Cambridge University Press
  • Release Date : 2019-06-13
  • ISBN : 9781108421768
GET THIS BOOKInteger Linear Programming in Computational and Systems Biology

This hands-on tutorial text for non-experts demonstrates biological applications of a versatile modeling and optimization technique.

Simulation Algorithms for Computational Systems Biology

Simulation Algorithms for Computational Systems Biology
  • Author : Luca Marchetti,Corrado Priami,Vo Hong Thanh
  • Publisher : Springer
  • Release Date : 2017-09-27
  • ISBN : 9783319631134
GET THIS BOOKSimulation Algorithms for Computational Systems Biology

This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections

Computational Systems Biology Approaches in Cancer Research

Computational Systems Biology Approaches in Cancer Research
  • Author : Inna Kuperstein,Emmanuel Barillot
  • Publisher : CRC Press
  • Release Date : 2019-09-09
  • ISBN : 9781000682922
GET THIS BOOKComputational Systems Biology Approaches in Cancer Research

Praise for Computational Systems BiologyApproaches in Cancer Research: "Complex concepts are written clearly and with informative illustrations and useful links. The book is enjoyable to read yet provides sufficient depth to serve as a valuable resource for both students and faculty." — Trey Ideker, Professor of Medicine, UC Xan Diego, School of Medicine "This volume is attractive because it addresses important and timely topics for research and teaching on computational methods in cancer research. It covers a broad variety of approaches,

Computational Systems Biology in Medicine and Biotechnology

Computational Systems Biology in Medicine and Biotechnology
  • Author : Sonia Cortassa,Miguel A. Aon
  • Publisher : Humana
  • Release Date : 2022-06-23
  • ISBN : 107161830X
GET THIS BOOKComputational Systems Biology in Medicine and Biotechnology

This volume addresses the latest state-of-the-art systems biology-oriented approaches that--driven by big data and bioinformatics--are utilized by Computational Systems Biology, an interdisciplinary field that bridges experimental tools with computational tools to tackle complex questions at the frontiers of knowledge in medicine and biotechnology. The chapters in this book are organized into six parts: systems biology of the genome, epigenome, and redox proteome; metabolic networks; aging and longevity; systems biology of diseases; spatiotemporal patterns of rhythms, morphogenesis, and complex dynamics; and

Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances
  • Author : Lecca, Paola
  • Publisher : IGI Global
  • Release Date : 2011-12-31
  • ISBN : 9781613504369
GET THIS BOOKSystemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science. Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and

An Introduction to Systems Biology

An Introduction to Systems Biology
  • Author : Uri Alon
  • Publisher : CRC Press
  • Release Date : 2006-07-07
  • ISBN : 9781584886426
GET THIS BOOKAn Introduction to Systems Biology

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the

Systems Biology and Bioinformatics

Systems Biology and Bioinformatics
  • Author : Kayvan Najarian,Siamak Najarian,Shahriar Gharibzadeh,Christopher N. Eichelberger
  • Publisher : CRC Press
  • Release Date : 2009-04-13
  • ISBN : 9781439882948
GET THIS BOOKSystems Biology and Bioinformatics

The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology
  • Author : Hamid R Arabnia,Quoc Nam Tran
  • Publisher : Morgan Kaufmann
  • Release Date : 2015-08-11
  • ISBN : 9780128026465
GET THIS BOOKEmerging Trends in Computational Biology, Bioinformatics, and Systems Biology

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques. • Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid

Cancer Systems Biology

Cancer Systems Biology
  • Author : Edwin Wang
  • Publisher : CRC Press
  • Release Date : 2010-05-04
  • ISBN : 1439811865
GET THIS BOOKCancer Systems Biology

The unprecedented amount of data produced with high-throughput experimentation forces biologists to employ mathematical representation and computation methods to glean meaningful information in systems-level biology. Applying this approach to the underlying molecular mechanisms of tumorigenesis, cancer researchers can uncover a series of new discov

Artificial Intelligence Methods and Tools for Systems Biology

Artificial Intelligence Methods and Tools for Systems Biology
  • Author : W. Dubitzky,Francisco Azuaje
  • Publisher : Springer
  • Release Date : 2006-08-02
  • ISBN : 9781402028656
GET THIS BOOKArtificial Intelligence Methods and Tools for Systems Biology

This book provides simultaneously a design blueprint, user guide, research agenda, and communication platform for current and future developments in artificial intelligence (AI) approaches to systems biology. It places an emphasis on the molecular dimension of life phenomena and in one chapter on anatomical and functional modeling of the brain. As design blueprint, the book is intended for scientists and other professionals tasked with developing and using AI technologies in the context of life sciences research. As a user guide,