Clinical Studies and Therapies in Parkinson s Disease

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Read or download book entitled Clinical Studies and Therapies in Parkinson s Disease written by Juan Segura-Aguilar and published by Academic Press in PDF, EPUB and Kindle Format. Click Get This Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like. We cannot guarantee that Clinical Studies and Therapies in Parkinson s Disease book is available in the library.

  • Publisher : Academic Press
  • Release : 12 June 2021
  • ISBN : 9780128221587
  • Page : 306 pages
  • Rating : 4.5/5 from 103 voters

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More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

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Clinical Studies and Therapies in Parkinson's Disease

Clinical Studies and Therapies in Parkinson's Disease
  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Release Date : 2021-06-12
  • ISBN : 9780128221587
GET THIS BOOKClinical Studies and Therapies in Parkinson's Disease

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains

Clinical Trials In Parkinson's Disease

Clinical Trials In Parkinson's Disease
  • Author : Santiago Perez-Lloret
  • Publisher : Humana
  • Release Date : 2020-08-19
  • ISBN : 1071609114
GET THIS BOOKClinical Trials In Parkinson's Disease

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the

Restorative Therapies in Parkinson's Disease

Restorative Therapies in Parkinson's Disease
  • Author : Patrik Brundin,C. Warren Olanow
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-08-31
  • ISBN : 9780387328232
GET THIS BOOKRestorative Therapies in Parkinson's Disease

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience

Selegiline in the Treatment of Parkinson's Disease

Selegiline in the Treatment of Parkinson's Disease
  • Author : Esa Heinonen
  • Publisher : Unknown
  • Release Date : 1995
  • ISBN : 9512904411
GET THIS BOOKSelegiline in the Treatment of Parkinson's Disease

Non-Motor Symptoms of Parkinson's Disease

Non-Motor Symptoms of Parkinson's Disease
  • Author : K. Ray Chaudhuri,Eduardo Tolosa,Anthony H. V. Schapira,Werner Poewe
  • Publisher : Oxford University Press, USA
  • Release Date : 2014
  • ISBN : 9780199684243
GET THIS BOOKNon-Motor Symptoms of Parkinson's Disease

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized

Towards New Therapies for Parkinson's Disease

Towards New Therapies for Parkinson's Disease
  • Author : David Finkelstein
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-11-02
  • ISBN : 9789533074634
GET THIS BOOKTowards New Therapies for Parkinson's Disease

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The

Deep Brain Stimulation for Parkinson's Disease

Deep Brain Stimulation for Parkinson's Disease
  • Author : Gordon H. Baltuch,Matthew B. Stern
  • Publisher : CRC Press
  • Release Date : 2007-03-19
  • ISBN : 9781420019759
GET THIS BOOKDeep Brain Stimulation for Parkinson's Disease

Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Etiology of Parkinson's Disease

Etiology of Parkinson's Disease
  • Author : Jonas H. Ellenberg,William C. Koller,James William Langston
  • Publisher : CRC Press
  • Release Date : 1995-03-01
  • ISBN : 0824788230
GET THIS BOOKEtiology of Parkinson's Disease

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Clinical Trials In Parkinson's Disease

Clinical Trials In Parkinson's Disease
  • Author : Santiago Perez-Lloret
  • Publisher : Unknown
  • Release Date : 2021
  • ISBN : 1071609122
GET THIS BOOKClinical Trials In Parkinson's Disease

Recent Advances in Parkinson's Disease

Recent Advances in Parkinson's Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-04-02
  • ISBN : 9780444642615
GET THIS BOOKRecent Advances in Parkinson's Disease

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?,

Diagnosis and Treatment of Parkinson's Disease

Diagnosis and Treatment of Parkinson's Disease
  • Author : Cindy Levine
  • Publisher : Department of Health and Human Services Pu Ncy for Healthcare Res
  • Release Date : 2003-01-01
  • ISBN : 1587630885
GET THIS BOOKDiagnosis and Treatment of Parkinson's Disease

Therapeutics of Parkinson's Disease and Other Movement Disorders

Therapeutics of Parkinson's Disease and Other Movement Disorders
  • Author : Mark Hallett,Werner Poewe
  • Publisher : John Wiley & Sons
  • Release Date : 2008-10-13
  • ISBN : 9780470714003
GET THIS BOOKTherapeutics of Parkinson's Disease and Other Movement Disorders

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

Rating Scales in Parkinson's Disease

Rating Scales in Parkinson's Disease
  • Author : Cristina Sampaio,Christopher G. Goetz,Anette Schrag
  • Publisher : Oxford University Press
  • Release Date : 2012-06-28
  • ISBN : 9780199783106
GET THIS BOOKRating Scales in Parkinson's Disease

For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains

Levodopa-Induced Dyskinesia in Parkinson's Disease

Levodopa-Induced Dyskinesia in Parkinson's Disease
  • Author : Susan H. Fox,Jonathan M. Brotchie
  • Publisher : Springer
  • Release Date : 2014-10-08
  • ISBN : 9781447165033
GET THIS BOOKLevodopa-Induced Dyskinesia in Parkinson's Disease

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions

Parkinson's Disease and the Family

Parkinson's Disease and the Family
  • Author : Nutan Sharma,Elaine Richman
  • Publisher : Harvard University Press
  • Release Date : 2009-06-30
  • ISBN : 9780674267305
GET THIS BOOKParkinson's Disease and the Family

Too often, with Parkinson's disease, a loved one serves as medical interpreter, patient advocate, and caregiver. Sharma and Richman draw on the latest research and clinical practice techniques to offer valuable suggestions for managing patient care and, perhaps more important, for healing the family unit.