Chemical Biology of the Genome

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  • Publisher : Academic Press
  • Release : 14 May 2021
  • ISBN : 9780128176450
  • Page : 352 pages
  • Rating : 4.5/5 from 103 voters

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Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

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Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy,Tapas K. Kundu
  • Publisher : Academic Press
  • Release Date : 2021-05-14
  • ISBN : 9780128176450
GET THIS BOOKChemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout,

Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release Date : 2017-09-19
  • ISBN : 9789811065477
GET THIS BOOKAdvancing Development of Synthetic Gene Regulators

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates

Chemical Genomics

Chemical Genomics
  • Author : Haian Fu
  • Publisher : Cambridge University Press
  • Release Date : 2012-02-13
  • ISBN : 9781107377585
GET THIS BOOKChemical Genomics

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals;

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release Date : 2020-10-01
  • ISBN : 9783030447434
GET THIS BOOKThe Chemical Biology of Long Noncoding RNAs

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A

Chemical Biology of Natural Products

Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher : CRC Press
  • Release Date : 2017-09-22
  • ISBN : 9781351643283
GET THIS BOOKChemical Biology of Natural Products

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing

Chemical Genomics

Chemical Genomics
  • Author : Stefan Jaroch,Hilmar Weinmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-26
  • ISBN : 9783540376354
GET THIS BOOKChemical Genomics

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening

CRISPR

CRISPR
  • Author : Rodolphe Barrangou,Erik Sontheimer,Luciano Marraffini
  • Publisher : John Wiley & Sons
  • Release Date : 2022-09-14
  • ISBN : 9781683670377
GET THIS BOOKCRISPR

CRISPR CRISPR: BIOLOGY AND APPLICATIONS “An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most

Chemical Genomics

Chemical Genomics
  • Author : Edward D. Zanders
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-04
  • ISBN : 9781592599486
GET THIS BOOKChemical Genomics

Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations.

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids
  • Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
  • Publisher : Springer Science & Business
  • Release Date : 2014-04-22
  • ISBN : 9783642544521
GET THIS BOOKChemical Biology of Nucleic Acids

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
  • Author : ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-21
  • ISBN : 9783642196157
GET THIS BOOKChemogenomics and Chemical Genetics

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : 0815332181
GET THIS BOOKMolecular Biology of the Cell

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
  • Author : Sheng Ding
  • Publisher : John Wiley & Sons
  • Release Date : 2008-02-08
  • ISBN : 9780470199121
GET THIS BOOKChemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

High Throughput Screening Methods

High Throughput Screening Methods
  • Author : Joshua A. Bittker,Nathan T. Ross
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-12-08
  • ISBN : 9781782624714
GET THIS BOOKHigh Throughput Screening Methods

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading

Chemical Biology

Chemical Biology
  • Author : Anonim
  • Publisher : Springer Nature
  • Release Date : 2012
  • ISBN : 9783662644126
GET THIS BOOKChemical Biology

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
  • Author : ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
  • Publisher : Springer
  • Release Date : 2016-08-23
  • ISBN : 3662519917
GET THIS BOOKChemogenomics and Chemical Genetics

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently