Carbohydrates in Drug Discovery and Development

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  • Publisher : Elsevier
  • Release : 31 July 2020
  • ISBN : 9780128166765
  • Page : 714 pages
  • Rating : 4.5/5 from 103 voters

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Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

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Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
  • Author : Vinod K. Tiwari
  • Publisher : Elsevier
  • Release Date : 2020-07-31
  • ISBN : 9780128166765
GET THIS BOOKCarbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the

Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • ISBN : 9783527605781
GET THIS BOOKCarbohydrate-based Drug Discovery

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume

Carbohydrates in Drug Design and Discovery

Carbohydrates in Drug Design and Discovery
  • Author : Jesus Jimenez-Barbero,F. Javier Canada,Sonsoles Martin-Santamaria
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-03-30
  • ISBN : 9781849739993
GET THIS BOOKCarbohydrates in Drug Design and Discovery

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections,

Carbohydrates as Drugs

Carbohydrates as Drugs
  • Author : Peter H. Seeberger,Christoph Rademacher
  • Publisher : Springer
  • Release Date : 2014-11-14
  • ISBN : 9783319086750
GET THIS BOOKCarbohydrates as Drugs

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series

The Organic Chemistry of Sugars

The Organic Chemistry of Sugars
  • Author : Daniel E. Levy,Peter Fügedi
  • Publisher : CRC Press
  • Release Date : 2005-09-21
  • ISBN : 9781420027952
GET THIS BOOKThe Organic Chemistry of Sugars

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Carbohydrate Chemistry

Carbohydrate Chemistry
  • Author : Laura Cipolla
  • Publisher : Unknown
  • Release Date : 2015
  • ISBN : 1783267194
GET THIS BOOKCarbohydrate Chemistry

The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of

Carbohydrate Recognition

Carbohydrate Recognition
  • Author : Binghe Wang,Geert-Jan Boons
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • ISBN : 1118017579
GET THIS BOOKCarbohydrate Recognition

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Carbohydrate-based Drug Discovery, 2 Volume Set

Carbohydrate-based Drug Discovery, 2 Volume Set
  • Author : Chi-Huey Wong
  • Publisher : John Wiley & Sons
  • Release Date : 2003-10-17
  • ISBN : 9783527306329
GET THIS BOOKCarbohydrate-based Drug Discovery, 2 Volume Set

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume

Drug Discovery and Development

Drug Discovery and Development
  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release Date : 2021-02-15
  • ISBN : 9789811555343
GET THIS BOOKDrug Discovery and Development

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable

Carbohydrate Chemistry

Carbohydrate Chemistry
  • Author : Paul Kosma,Tanja M. Wrodnigg,Arnold Stütz
  • Publisher : CRC Press
  • Release Date : 2021-01-14
  • ISBN : 9781351256070
GET THIS BOOKCarbohydrate Chemistry

Volumes in the Proven Synthetic Methods Series address the concerns many chemists have regarding irreproducibility of synthetic protocols, lack of identification and characterization data for new compounds, and inflated yields reported in chemical communications—trends that have recently become a serious problem. Exploring carbohydrate chemistry from both the academic and industrial points of view, this unique resource brings together useful information into one convenient reference. The series is unique among other synthetic literature in the carbohydrate field in that, to

Carbohydrate Drug Design

Carbohydrate Drug Design
  • Author : Anatoliĭ Alekseevich Klesov,Zbigniew J. Witczak,David Platt
  • Publisher : Amer Chemical Society
  • Release Date : 2006
  • ISBN : UOM:39015064134219
GET THIS BOOKCarbohydrate Drug Design

It is becoming more obvious in recent years that carbohydrates present a new dimension in drug design for targeting specific diseases. Carbohydrates birthed a whole new vocabulary into chemistry, biochemistry and related disciplines -- a new language in the form of distinct characters and images providing professional chemists not in the area of carbohydrates to become familiar and knowledgeable on the topic. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases

Water Extraction of Bioactive Compounds

Water Extraction of Bioactive Compounds
  • Author : Herminia Dominguez,Maria Jesus Gonzalez Munoz
  • Publisher : Elsevier
  • Release Date : 2017-09-20
  • ISBN : 9780128096154
GET THIS BOOKWater Extraction of Bioactive Compounds

Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers,

Carbohydrate-Based Vaccines and Immunotherapies

Carbohydrate-Based Vaccines and Immunotherapies
  • Author : Zhongwu Guo,Geert-Jan Boons
  • Publisher : John Wiley & Sons
  • Release Date : 2009-06-17
  • ISBN : 9780470473276
GET THIS BOOKCarbohydrate-Based Vaccines and Immunotherapies

The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including

Drug Discovery and Development, Volume 1

Drug Discovery and Development, Volume 1
  • Author : Mukund S. Chorghade
  • Publisher : John Wiley & Sons
  • Release Date : 2006-07-18
  • ISBN : 9780471780090
GET THIS BOOKDrug Discovery and Development, Volume 1

This two volume set provides a comprehensive account of the entiresequence of operations involved in discovering a drug through theactual delivery of the drug to clinicians and medicalpractitioners. Includes case studies of the discovery of erythromycin analogs(antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment andmanagement of bacterial infections, Parkinson's disease, psoriasis,ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics The first volume

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design
  • Author : Sanjeev Kumar Singh
  • Publisher : Springer Nature
  • Release Date : 2021-02-02
  • ISBN : 9789811589362
GET THIS BOOKInnovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it