Cancer Leading Proteases

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  • Publisher : Academic Press
  • Release : 03 February 2020
  • ISBN : 9780128181683
  • Page : 526 pages
  • Rating : 4.5/5 from 103 voters

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Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

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Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2020-02-03
  • ISBN : 9780128181683
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2020-01-09
  • ISBN : 9780128181690
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release Date : 2017-11-15
  • ISBN : 9789811061417
GET THIS BOOKPathophysiological Aspects of Proteases

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making

Proteolytic Signaling in Health and Disease

Proteolytic Signaling in Health and Disease
  • Author : Andre Zelanis
  • Publisher : Academic Press
  • Release Date : 2021-10-13
  • ISBN : 9780323856973
GET THIS BOOKProteolytic Signaling in Health and Disease

In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound

The Cancer Degradome

The Cancer Degradome
  • Author : Dylan Edwards,Gunilla Hoyer-Hansen,Francesco Blasi,B.F. Sloane
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-09-16
  • ISBN : 9780387690575
GET THIS BOOKThe Cancer Degradome

This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Proteases and Their Inhibitors in Cancer Metastasis

Proteases and Their Inhibitors in Cancer Metastasis
  • Author : J-M. Foidart,R.J. Muschel
  • Publisher : Springer Science & Business Media
  • Release Date : 2002
  • ISBN : 1402009232
GET THIS BOOKProteases and Their Inhibitors in Cancer Metastasis

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as

Proteases in Physiology and Pathology

Proteases in Physiology and Pathology
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release Date : 2017-09-14
  • ISBN : 9789811025136
GET THIS BOOKProteases in Physiology and Pathology

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect

Matrix Proteases in Health and Disease

Matrix Proteases in Health and Disease
  • Author : Niels Behrendt
  • Publisher : John Wiley & Sons
  • Release Date : 2012-07-10
  • ISBN : 9783527329915
GET THIS BOOKMatrix Proteases in Health and Disease

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease

Functional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity-based Probes

Functional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity-based Probes
  • Author : Laura Elizabeth Edgington
  • Publisher : Unknown
  • Release Date : 2012
  • ISBN : OCLC:794730518
GET THIS BOOKFunctional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity-based Probes

Cysteine proteases use a catalytic thiol to cleave amide bonds of protein substrates. This activity serves as an important regulatory mechanism for diverse cellular processes necessary for normal physiology. Dysregulated protease activity is a hallmark of numerous diseases, including atherosclerosis, arthritis, stroke, macular degeneration, neurodegenerative disorders, inflammatory diseases, and cancer. In the last decades, the field of activity-based proteomics has produced a number of tools for dissecting protease function. In the introductory chapter, I will discuss the current state of

Proteases in Human Diseases

Proteases in Human Diseases
  • Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release Date : 2017-07-13
  • ISBN : 9789811031625
GET THIS BOOKProteases in Human Diseases

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse

Determining Gene Expression, Substrate Specifically and Natural Substrates for Prostate Associated Proteases

Determining Gene Expression, Substrate Specifically and Natural Substrates for Prostate Associated Proteases
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2001
  • ISBN : OCLC:946237000
GET THIS BOOKDetermining Gene Expression, Substrate Specifically and Natural Substrates for Prostate Associated Proteases

Numerous studies have shown that proteolytic enzymes play an essential role in tumor invasion, metastasis and angiogenesis (1,2, 3). Proteases may enhance these processes through the release and/or activation of growth factors and the degradation of extracellular matrix. Thus, inhibition of these protease-mediated processes may be a therapeutic strategy for the treatment of metastatic cancer. Indeed, proteases, in general, have proven to be excellent chemotherapeutic targets as evidenced by the HIV protease inhibitors and the large number of successful clinical trials

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases
  • Author : Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk
  • Publisher : Springer
  • Release Date : 2018-05-22
  • ISBN : 9783319754741
GET THIS BOOKActivation of Viruses by Host Proteases

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in

Proteases and Cancer

Proteases and Cancer
  • Author : Santiago Cal,Alvaro J. Obaya
  • Publisher : Humana
  • Release Date : 2019-06-04
  • ISBN : 1493985310
GET THIS BOOKProteases and Cancer

This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography, angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily

The Serpin Family

The Serpin Family
  • Author : Margarethe Geiger,Felix Wahlmüller,Margareta Furtmüller
  • Publisher : Springer
  • Release Date : 2015-11-13
  • ISBN : 9783319227115
GET THIS BOOKThe Serpin Family

The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.​

Development of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers

Development of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers
  • Author : Desiree Ellene Mendes
  • Publisher : Unknown
  • Release Date : 2016
  • ISBN : OCLC:962268467
GET THIS BOOKDevelopment of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers

The development of highly tuned diagnostic agents are critical for the early detection of cancer and are commonly designed to bind cell surface receptors. A small library of first-generation phosphoramidate inhibitors leading to sub-micromolar potency as determined by a FRET-based spectrophotometric assay were generated as peptide mimics with a scaffold designed to interact with the S1, S1` register of the catalytic domain of the cell surface receptor matrix metalloproteinase (MMP-14). Candidate residues were selected for the scaffold using in silico