Biological DNA Sensor

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  • Publisher : Academic Press
  • Release : 30 October 2013
  • ISBN : 9780124051683
  • Page : 368 pages
  • Rating : 4.5/5 from 103 voters

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Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

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Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release Date : 2013-10-30
  • ISBN : 9780124051683
GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken J. Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release Date : 2013-11-07
  • ISBN : 0124047327
GET THIS BOOKBiological DNA Sensor

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete

Biological DNA Sensor

Biological DNA Sensor
  • Author : Søren R. Paludan,Andrew G. Bowie
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068816
GET THIS BOOKBiological DNA Sensor

Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed DNA sensors in host defense and diseases. Much of the current knowledge on DNA sensing has been obtained through studies with herpesviruses. Hence, in this chapter, we review and critically assess

Biological DNA Sensor

Biological DNA Sensor
  • Author : Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068748
GET THIS BOOKBiological DNA Sensor

In this chapter, we reflect on our early understanding of the immunogenic properties of dsDNA and give a chronological account of the journey we have taken to discover the individual cellular DNA sensors which have played important roles in mediating DNA induced inflammation.

Biological DNA Sensor

Biological DNA Sensor
  • Author : Glen N. Barber
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068762
GET THIS BOOKBiological DNA Sensor

Invading microbes are detected by cellular sensors, the consequences of which result in the production of potent anti-pathogen proteins such as type I interferon (IFN) as well as other cytokines capable of stimulating the adaptive immune response. Examples comprise the RIG-I-like helicase (RLH) and the Toll-like receptor (TLR) families which recognize non-self-pathogen derived molecules (PAMPs) including bacterial lipopolysaccharides as well as nucleic acids. In addition, an endoplasmic reticulum (ER) associated transmembrane protein referred to as STING (for stimulator of interferon

Biological DNA Sensor

Biological DNA Sensor
  • Author : Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068847
GET THIS BOOKBiological DNA Sensor

Ideal vaccines are expected to give lifetime protection from infectious diseases, and if possible, from allergic diseases, autoimmune diseases and cancer. DNA vaccination was introduced two decades ago as a simple plasmid inoculation method with a capability of inducing both cellular and humoral immune responses. Recent studies have provided insights into the molecular mechanisms by which the double-stranded structure of DNA vaccine induces the activation of type-I interferon (IFN)-mediated innate immune responses via STING/TBK1 complex, similar to cytosolic

Biological DNA Sensor

Biological DNA Sensor
  • Author : Rebecca Schmidt,Laurel L. Lenz
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068861
GET THIS BOOKBiological DNA Sensor

Cyclic dinucleotides (c-di-NMPs), such as c-di-GMP and c-di-AMP were first discovered in bacteria, where they play important roles as second messenger molecules that regulate bacterial cellular functions. In addition, these and other c-di-NMPs exert potent biological effects on mammalian cells, such as the inhibition of cancer cell proliferation, immune cell activation, and the triggering of type I interferon production. Here, we introduce the biology of c-di-NMPs in bacterial systems and review the current state of the literature on their biological

Biological DNA Sensor

Biological DNA Sensor
  • Author : Christophe J. Desmet
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068854
GET THIS BOOKBiological DNA Sensor

Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of studies aiming to decipher the immunological mechanisms of action of alum. Along with other hypotheses, recent reports support that alum induces the release by host cells of their own DNA at sites of injection. Extracellular self-DNA would in turn activate the innate immune system through known and yet to be identified innate immune

Biological DNA Sensor

Biological DNA Sensor
  • Author : Y.J. Shen,A.R. Lam,S.W.S. Ho,C.X. Koo,N. Le Bert,S. Gasser
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068823
GET THIS BOOKBiological DNA Sensor

Toll-like receptors, NOD-like receptors and numerous intracellular sensors that detect nucleotides in the cytosol help to initiate immune responses to viral infections. Many of the cytosolic nucleotide sensors and their downstream mediators also play a role in RNA metabolism, DNA repair and cancer. Here we review the evidence that links cytosolic DNA sensors to processes that are activated in cancer cells.

Biological DNA Sensor

Biological DNA Sensor
  • Author : Jan Naujoks,Bastian Opitz
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068809
GET THIS BOOKBiological DNA Sensor

The detection of bacterial pathogens by the innate immune system is mediated by various pattern recognition receptors that sense microbial molecules such as cell wall components, virulence factors or nucleic acids. Bacterial DNA is recognized by Toll-like receptor 9 (TLR9) at endosomal compartments and by cyclic GMP-AMP synthase, polymerase III/RIG-I, AIM2-like receptors (ALRs), DNA helicases as well as other incompletely characterized proteins in the host cell cytosol. Depending on the receptor and specific engagement of the adapter molecules MyD88,

Biological DNA Sensor

Biological DNA Sensor
  • Author : Sivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgerald
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • ISBN : 9780128068755
GET THIS BOOKBiological DNA Sensor

The innate immune response serves as the first line of defense against microbial infections by detecting pathogen-associated molecular patterns through germline-encoded pattern recognition receptors. Proteins of the PYHIN family have gained substantial research focus in recent years as central mediators of innate immune responses induced by cytosolic microbial DNA. Sensing of DNA by PYHINs typically leads to activation of inflammasomes and/or type I interferon responses that are crucial for host defense against invading pathogens. Certain members of the family

DNA Conjugates and Sensors

DNA Conjugates and Sensors
  • Author : Keith R Fox,Tom Brown
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-11-30
  • ISBN : 9781849734936
GET THIS BOOKDNA Conjugates and Sensors

Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of

Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism

Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism
  • Author : Ashok Vaseashta,Eric Braman,Philip Susmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-01-05
  • ISBN : 9789400724877
GET THIS BOOKTechnological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism

This book arises from the NATO Advanced Study Institute “Technological Innovations in Detection and Sensing of CBRN Agents and Ecological Terrorism” held in Chisinau, Republic of Moldova in June 2010. It comprises a variety of invited contributions by highly experienced educators, scientists, and industrialists, and is structured to cover important aspects of the field that include developments in chemical-biological, and radiation sensing, synthesis and processing of sensors, and applications of sensors in detecting/monitoring contaminants introduced/dispersed inadvertently or intentionally in

Electrochemical Biosensors

Electrochemical Biosensors
  • Author : Ali A. Ensafi
  • Publisher : Elsevier
  • Release Date : 2019-07-25
  • ISBN : 9780128164921
GET THIS BOOKElectrochemical Biosensors

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the

Sensors for Chemical and Biological Applications

Sensors for Chemical and Biological Applications
  • Author : Manoj Kumar Ram,Venkat R. Bhethanabotla
  • Publisher : CRC Press
  • Release Date : 2018-10-03
  • ISBN : 9781420005042
GET THIS BOOKSensors for Chemical and Biological Applications

In recent years, sensor research has undergone a quiet revolution that will have a significant impact on a broad range of applications in areas such as health care, the environment, energy, food safety, national security, and manufacturing. Sensors for Chemical and Biological Applications discusses in detail the potential of chemical and biological sensors and examines how they are meeting the challenges of chem-bio terrorism by monitoring through enhanced specificity, fast response times, and the ability to determine multiple hazardous substances.