Biochemistry of Collagens Laminins and Elastin

Book Biochemistry of Collagens  Laminins and Elastin Cover

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  • Publisher : Academic Press
  • Release : 15 May 2019
  • ISBN : 0128170689
  • Page : 416 pages
  • Rating : 4.5/5 from 103 voters

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There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes eight new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability

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Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2019-05-15
  • ISBN : 0128170689
GET THIS BOOKBiochemistry of Collagens, Laminins and Elastin

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2016-07-29
  • ISBN : 9780128098998
GET THIS BOOKBiochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2019-05-28
  • ISBN : 9780128170694
GET THIS BOOKBiochemistry of Collagens, Laminins and Elastin

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally

Progress in Heritable Soft Connective Tissue Diseases

Progress in Heritable Soft Connective Tissue Diseases
  • Author : Jaroslava Halper
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-18
  • ISBN : 9789400778931
GET THIS BOOKProgress in Heritable Soft Connective Tissue Diseases

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and

The Extracellular Matrix Factsbook

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  • Author : Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth
  • Publisher : Elsevier
  • Release Date : 1998-03-27
  • ISBN : 9780080531519
GET THIS BOOKThe Extracellular Matrix Factsbook

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries

Cell Surface Proteins of Gram-positive Pathogenic Bacteria

Cell Surface Proteins of Gram-positive Pathogenic Bacteria
  • Author : Magnus Hook,Timothy J. Foster
  • Publisher : Frontiers Media SA
  • Release Date : 2021-07-14
  • ISBN : 9782889710461
GET THIS BOOKCell Surface Proteins of Gram-positive Pathogenic Bacteria

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-02-16
  • ISBN : 9783642165559
GET THIS BOOKThe Extracellular Matrix: an Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept

Methods in Extracellular Matrix Biology

Methods in Extracellular Matrix Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-01-05
  • ISBN : 9780128122983
GET THIS BOOKMethods in Extracellular Matrix Biology

Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis

Extracellular Matrix Degradation

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  • Author : William C. Parks,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • ISBN : 9783642168611
GET THIS BOOKExtracellular Matrix Degradation

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases,

Carbohydrate Chemistry: Chemical and Biological Approaches Volume 44

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  • Author : Amelia Pilar Rauter,Thisbe K Lindhorst,Yves Queneau
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-10-06
  • ISBN : 9781788013680
GET THIS BOOKCarbohydrate Chemistry: Chemical and Biological Approaches Volume 44

Carbohydrate Chemistry is an invaluable volume demonstrating the interdisciplinary nature of modern carbohydrate research and containing analysed, evaluated and distilled information on the latest research in the area.

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  • Author : Francesco Travascio
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-15
  • ISBN : 9789535124153
GET THIS BOOKComposition and Function of the Extracellular Matrix in the Human Body

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book

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Evolution of Extracellular Matrix
  • Author : Fred W. Keeley,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-15
  • ISBN : 9783642360022
GET THIS BOOKEvolution of Extracellular Matrix

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of

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  • Author : J. Robin Harris,Viktor I. Korolchuk
  • Publisher : Springer
  • Release Date : 2019-03-19
  • ISBN : 9789811336812
GET THIS BOOKBiochemistry and Cell Biology of Ageing: Part II Clinical Science

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are

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  • Author : Aleksander Krag,Torben Hansen
  • Publisher : Springer
  • Release Date : 2018-11-09
  • ISBN : 9783319988900
GET THIS BOOKThe Human Gut-Liver-Axis in Health and Disease

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The

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  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • ISBN : 0815332181
GET THIS BOOKMolecular Biology of the Cell