Benzodiazepine Based Drug Discovery

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  • Publisher : Elsevier
  • Release : 26 August 2022
  • ISBN : 9780323860109
  • Page : 338 pages
  • Rating : 4.5/5 from 103 voters

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Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry. The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities. Presents detailed coverage of chemical structures and practical synthetic methods of benzodiazepines and benzothiazepines in drug discovery Compiles detailed in vivo and in vitro biological activity data of 1,4-benzodiazepine- and 1,5-benzodiazepine-based drugs that will help researchers design and develop innovative drugs Discusses promising avenues and potential challenges in the development of new benzodiazepines and benzothiazepines in medicinal drug synthesis

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Benzodiazepine-Based Drug Discovery

Benzodiazepine-Based Drug Discovery
  • Author : Farzad Zamani,Esmail Doustkhah
  • Publisher : Elsevier
  • Release Date : 2022-08-26
  • ISBN : 9780323860109
GET THIS BOOKBenzodiazepine-Based Drug Discovery

Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes,

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-27
  • ISBN : 9781118145661
GET THIS BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—

Privileged Scaffolds in Medicinal Chemistry

Privileged Scaffolds in Medicinal Chemistry
  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • ISBN : 9781782620303
GET THIS BOOKPrivileged Scaffolds in Medicinal Chemistry

This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

Peripheral Benzodiazepine Receptors

Peripheral Benzodiazepine Receptors
  • Author : Eva Giesen-Crouse,Peter Jenner
  • Publisher : Academic Press
  • Release Date : 1993-05-05
  • ISBN : UOM:39015031796363
GET THIS BOOKPeripheral Benzodiazepine Receptors

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Although peripheral type benzodiazepne recognition sites have been demonstrated in the brain and peripheral organs of various species for more than 10 years, the exact physiological

The Benzodiazepines

The Benzodiazepines
  • Author : J. Marks
  • Publisher : Springer
  • Release Date : 2012-02-23
  • ISBN : 9401162050
GET THIS BOOKThe Benzodiazepines

The story of the benzodiazepines is a fascinating one: the synthesis of a long series of inert compounds and the abandonment of the project: months later, the renewal of the project and the discovery that this compound R05-0690 (Librium ®) was a sedative and muscle relaxant in laboratory animals: the recognition that its postulated structure was wrong and that it was in fact a member of an entirely new chemical class: the excitement caused by the discovery of the powerful

Good Chemistry

Good Chemistry
  • Author : Alex Baenninger
  • Publisher : McGraw Hill Professional
  • Release Date : 2004
  • ISBN : 0071426175
GET THIS BOOKGood Chemistry

The development of Valium by Roche Pharmaceutical and the entire benzodiazepine group of active substances was among the greatest accomplishments in 20th-century pharmacology. Good Chemistry combines a detailed account of this momentous development with an engaging biography of Leo Sternbach, the brilliant chemist who invented Valium and whose achievements heralded the beginning of a new era in research and therapeutics. This thought-provoking biographical history: Tells the fascinating life story of one of the 20th century's premier chemists Traces the developments

Pyrrolo-Benzodiazepine Class of Privileged Medicinal Scaffolds

Pyrrolo-Benzodiazepine Class of Privileged Medicinal Scaffolds
  • Author : Sumitra Nain,Prof. D. Kishore,Prof. B. P. Nagori
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2011-08
  • ISBN : 3845421517
GET THIS BOOKPyrrolo-Benzodiazepine Class of Privileged Medicinal Scaffolds

On account of the wide range of the biological properties displayed by benzodiazepine derived compounds, benzodiazepine scaffold have been considered among the most important privileged structures for drug discovery. The development of novel biological materials based on the privileged structure is an intense area of research. Global efforts are underway to develop chemotherapeutic agentsThe main thrust of work in the area of additional fused heterocyclic rings is stimulated by the isolation of a series of antitumor antibiotics such as anthramycin,

Analogue-based Drug Discovery

Analogue-based Drug Discovery
  • Author : IUPAC,János Fischer,C. Robin Ganellin
  • Publisher : John Wiley & Sons
  • Release Date : 2006-12-13
  • ISBN : 9783527607495
GET THIS BOOKAnalogue-based Drug Discovery

The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in

Receptor Binding in Drug Research

Receptor Binding in Drug Research
  • Author : Robert A. O'Brien
  • Publisher : CRC Press
  • Release Date : 2020-08-27
  • ISBN : 9781000146776
GET THIS BOOKReceptor Binding in Drug Research

This book describes the applications of receptor techniques in many different areas in addition to conventional drug and neurotransmitter binding sites. It reviews humoral modulators such as a leukotrienes, interferon, platelet-derived growth factor, and novel endogenous ligands.

Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques

Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques
  • Author : Vijendra K. Singh,Margaret E. Gnegy,S. P. Gupta,R. Leurs,R. C. Vollinga,H. Timmerman,Ray W. Fuller,Nissim Claude Cohen,Vincenzo Tschinke,Elaine J. Benaksas,E. David Murray,William J. Wechter,Indra Dwivedy,Suprabhat Ray
  • Publisher : Birkhäuser
  • Release Date : 2012-03-17
  • ISBN : 303487166X
GET THIS BOOKProgress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques

Volume 45 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug

Caffeine for the Sustainment of Mental Task Performance

Caffeine for the Sustainment of Mental Task Performance
  • Author : Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research
  • Publisher : National Academies Press
  • Release Date : 2002-01-07
  • ISBN : 9780309082587
GET THIS BOOKCaffeine for the Sustainment of Mental Task Performance

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the

Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery
  • Author : Atta-ur Rahman,M. Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release Date : 2011-08-12
  • ISBN : 9781608051595
GET THIS BOOKFrontiers in CNS Drug Discovery

"Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an

Sleep, Benzodiazepines and Performance

Sleep, Benzodiazepines and Performance
  • Author : Ian Hindmarch,H. Ott,T. Roth
  • Publisher : Springer
  • Release Date : 2011-12-10
  • ISBN : 3642696619
GET THIS BOOKSleep, Benzodiazepines and Performance

The following papers were presented at an International Workshop on experi mental methodologies and research strategies in sleep, benzodiazepines and per formance during the VII. International Congress of Psychiatry in Vienna 1983. Authors were asked to examine and review the methods used and the results obtained from the various studies within their particular expertise and to provide guidelines for future strategies in the psychopharmacology of sleep. It has long been felt by sleep researchers, psychopharmacologists and clini cians that the effects

Drug Discovery Handbook

Drug Discovery Handbook
  • Author : Shayne Cox Gad
  • Publisher : John Wiley & Sons
  • Release Date : 2005-06-24
  • ISBN : 9780471728771
GET THIS BOOKDrug Discovery Handbook

The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • ISBN : 9780309292498
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective