Ascaris

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  • Publisher : Academic Press
  • Release : 08 February 2023
  • ISBN : 0123969786
  • Page : 439 pages
  • Rating : 4.5/5 from 103 voters

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This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines. Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans, as disability adjusted life years approximating 10.5 million. Ascaris larvae develop in host parenteral tissues, and the resultant pathology has been condemnation. Ascariasis, despite its staggering global prevalence and the sheer numbers of people it infects, remains a classic neglected disease. However, renewed interest in the consequences of early infection with worms from the perspective of immune modulation, co-infections and the development of allergy further enhances the relevance of these parasites. Brings together a wide range of topics and approaches and recent, comprehensive and progressive research concerning the neglected parasite Ascaris Provides a blueprint of how a single parasite entity can stimulate interest in basic biology, clinical science, veterinary science, public health and epidemiology Presents a wealth of new insights given that a book on this parasite has not been published for over 20 years 16 chapters from a range of top authors from around the world

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Ascaris

Ascaris
  • Author : Celia Holland
  • Publisher : Academic Press
  • Release Date : 2013
  • ISBN : 0123969786
GET THIS BOOKAscaris

This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines. Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans,

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Celia Holland
  • Publisher : Newnes
  • Release Date : 2013-05-09
  • ISBN : 9780123972859
GET THIS BOOKAscaris: The Neglected Parasite

This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines. Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans,

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Celia V. Holland,Jerzy M. Behnke,Christina Dold
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061282
GET THIS BOOKAscaris: The Neglected Parasite

Larval ascariasis is much less well understood than adult worm infection. Part of the explanation for this is the difficulty in assessing the impact of larval infections in human subjects. In contrast, adult worms can be counted after post-chemotherapeutic expulsion or, additionally, eggs voided in host feces can be quantified as an indirect measure of infection intensity. Furthermore, respiratory and hepatic disease, which may be associated with transient passage of larvae through these organs, can be either non-specific or cryptic,

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Martin Walker,Andrew Hall,María-Gloria Basáñez
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061305
GET THIS BOOKAscaris: The Neglected Parasite

In the context of the current unprecedented momentum and commitment to control neglected tropical diseases, and the increased advocacy of anthelmintic mass drug administration (MDA), there are renewed calls for research and development into the epidemiology and population biology of helmintic parasites to be embedded at the core of intervention strategies. This review of the epidemiology of Ascaris lumbricoides – one of the three neglected soil-transmitted helminth infections of greatest public health importance – includes discussion on diagnostic methods and their limitations;

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Martha Betson,Peter Nejsum,J. Russell Stothard
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061336
GET THIS BOOKAscaris: The Neglected Parasite

To better understand the epidemiology of ascariasis, molecular genetic methods have been applied to differentiate between worms found infecting people and pigs, and other occasional hosts. Owing to difficulties in applying species concepts, the longstanding debate of the distinction(s) between Ascaris lumbricoides and Ascaris suum continues. From an applied perspective, however, molecular markers help to “tag” and “track” worms during their transmission cycle(s), providing new insights into host range, as well as methods for assessing parasite population dynamics

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Malcolm W. Kennedy
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061268
GET THIS BOOKAscaris: The Neglected Parasite

In comparison with other helminths that afflict humans on a global scale, Ascaris lumbricoides and ascariasis are relatively under-researched in terms of the proteins and other products to which the parasites expose their hosts. The reputation of the parasite as a source of potent allergens, and the recognition that immune hypersensitivity in the lung caused by migrating larvae is a significant problem, has served to focus attention on immune responses to Ascaris. Research has increasingly focused on the parasite’s

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Philip J. Cooper,Camila A. Figuieredo
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061244
GET THIS BOOKAscaris: The Neglected Parasite

Natural infections with Ascaris lumbricoides and A. suum of pigs and humans, respectively, have a worldwide distribution. Ascaris infections induce strong Th2 responses in the host that appear to be central to the development of protective immunity. Th2 responses may be modulated actively through a complex host–parasite interaction that allows the parasite to survive but also limits severe Th2-mediated pathology in the host. The increased production of IL-10 by regulatory cell populations may have a key role in

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Charles D. Criscione
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061312
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The fields of conservation genetics and genetic epidemiology share many parallel questions. Hence, methodologies can be adapted from the former to the latter. Three applications of population genetics are presented to further our understanding of Ascaris epidemiology. (1) I address if Ascaris infections in humans and pigs constitute a single population or subdivided host-affiliated populations with potential for cross-transmission and hybridization. (2) I discuss the use of landscape genetics as a means to identify transmission foci and epidemiologically relevant variables correlated to

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Luis Caraballo
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061251
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Ascaris lumbricoides infects humans causing ascariasis. The immune response to this helminth shares mechanisms with the allergic reaction and may influence the natural history of allergy phenotypes. The high levels of total IgE associated with ascariasis restrict the use of this test in the diagnosis of allergy. Also, the immunological cross-reactivity between Ascaris and domestic mites has implications in the diagnosis of both allergy and ascariasis. Depending on the infection intensity and host’s susceptibility, in countries where helminthiases are

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Johnny Vlaminck,Peter Geldhof
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061398
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Roundworms are the most prevalent parasite of swine in the world today. Their presence on a pig farm can have detrimental effects on farm profitability due to their impact on growth rate, feed conversion, and general health of the produced pigs. For farmers, it is therefore essential to be aware of the “worm status” of their herd in order to make informed decisions on how to control this disease on their farm. This chapter concentrates on the diverse aspects involved

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Simon J. Brooker,Rachel L. Pullan
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061367
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Ascariasis is a neglected tropical disease (NTD) affecting 763 million people worldwide, with nutritional and developmental consequences of chronic childhood infection and severe clinical disease occurring in heavy infections. Reliably estimating the extent of the problem of Ascaris lumbricoides and ascariasis is difficult because of inaccuracies in parasitological diagnosis, the non-specificity of clinical signs, and a paucity of reliable and accurate data. As a consequence, estimating the global distribution and disease burden has been based on informed approximations, using the best

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Aaron R. Jex,Shiping Liu,Bo Li,Neil D. Young,Ross S. Hall,Yingrui Li,Peter Geldhof,Peter Nejsum,Paul W. Sternberg,Jun Wang,Huanming Yang,Robin B. Gasser
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061343
GET THIS BOOKAscaris: The Neglected Parasite

Parasitic nematodes cause substantial morbidity and mortality in animals and people globally and major losses to food production annually. Ascaris is among the commonest geohelminths of swine and people worldwide, and causes major disease and socioeconomic losses, particularly in developing countries. The control of ascariasis has become a global health and welfare priority, but current treatment programs carry a significant risk of inducing anthelmintic resistance. Therefore, there is a need to work toward the sustainable control of Ascaris/ascariasis, built

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Sarah Williams-Blangero,Mona H. Fenstad,Satish Kumar,John Blangero
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061350
GET THIS BOOKAscaris: The Neglected Parasite

Ascaris infections remain major global public health problems despite the wide availability of cheap, effective anthelminthic drugs. An improved understanding of host susceptibility to Ascaris infection may suggest new approaches for targeting available drugs more effectively, or may suggest novel targets for drug development efforts. This chapter explores our current understanding of the underlying genetic architecture of susceptibility to Ascaris infection. The past and potential future uses of different types of genetic approaches, from quantitative genetic studies of heritability, to

Ascaris: The Neglected Parasite

Ascaris: The Neglected Parasite
  • Author : Antonio Montresor,Albis Francesco Gabrielli,Lorenzo Savioli
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-09
  • ISBN : 9780128061381
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Experiences from Japan and Korea demonstrated that when a country is developing economically, the periodic administration of anthelmintic (preventive chemotherapy) drastically reduces soil-transmitted helminthiasis (STH) and these advances are then maintained by increasing sanitation standards; both countries eliminated the morbidity due to STH in less than a decade. The situation is more complex in countries with slow economic development in which preventive chemotherapy should be maintained over a longer period of time in order to reduce morbidity due to STH.

Immunity to Parasitic Infection

Immunity to Parasitic Infection
  • Author : Tracey Lamb
  • Publisher : John Wiley & Sons
  • Release Date : 2012-08-10
  • ISBN : 9781118393338
GET THIS BOOKImmunity to Parasitic Infection

Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection. For