Animal Models in Cancer Drug Discovery

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  • Publisher : Academic Press
  • Release : 16 April 2019
  • ISBN : 9780128147054
  • Page : 470 pages
  • Rating : 4.5/5 from 103 voters

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Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

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Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • ISBN : 9780128147054
GET THIS BOOKAnimal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • ISBN : 9781607619680
GET THIS BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development
  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release Date : 2012-10-03
  • ISBN : 9781608054695
GET THIS BOOKTranslational Animal Models in Drug Discovery and Development

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach
  • Author : Kakoli Bose,Pradip Chaudhari
  • Publisher : Springer Nature
  • Release Date : 2019-11-25
  • ISBN : 9789813298163
GET THIS BOOKUnravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of

Alternatives to Animal Testing

Alternatives to Animal Testing
  • Author : Hajime Kojima,Troy Seidle,Horst Spielmann
  • Publisher : Springer
  • Release Date : 2018-12-27
  • ISBN : 9789811324475
GET THIS BOOKAlternatives to Animal Testing

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines,

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials
  • Author : Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam
  • Publisher : Frontiers Media SA
  • Release Date : 2019-12-23
  • ISBN : 9782889632497
GET THIS BOOK“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials

This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice.

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
  • Publisher : National Academies Press
  • Release Date : 2016-01-09
  • ISBN : 9780309379908
GET THIS BOOKThe Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research

Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • ISBN : 9783527333288
GET THIS BOOKIn vivo Models for Drug Discovery

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery
  • Author : Gabriele Proetzel,Michael V. Wiles
  • Publisher : Humana
  • Release Date : 2016-08-23
  • ISBN : 1493961217
GET THIS BOOKMouse Models for Drug Discovery

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of

Animal Models for Human Cancer

Animal Models for Human Cancer
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger
  • Publisher : John Wiley & Sons
  • Release Date : 2016-05-18
  • ISBN : 9783527695898
GET THIS BOOKAnimal Models for Human Cancer

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
  • Author : Kenneth K.W. To,William C.S. Cho
  • Publisher : Academic Press
  • Release Date : 2020-07-29
  • ISBN : 9780128199039
GET THIS BOOKDrug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and

Protocol Handbook for Cancer Biology

Protocol Handbook for Cancer Biology
  • Author : Gauri Misra,Jyotika Rajawat
  • Publisher : Academic Press
  • Release Date : 2021-02-12
  • ISBN : 9780323898171
GET THIS BOOKProtocol Handbook for Cancer Biology

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research

Mouse Models of Human Cancer

Mouse Models of Human Cancer
  • Author : Eric C. Holland
  • Publisher : Wiley-Liss
  • Release Date : 2004-08-27
  • ISBN : 9780471444602
GET THIS BOOKMouse Models of Human Cancer

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and

Phenotypic Drug Discovery

Phenotypic Drug Discovery
  • Author : Angelique Augustin,Beverley Isherwood
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-10
  • ISBN : 9781788018760
GET THIS BOOKPhenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and

Immunodeficient Animals

Immunodeficient Animals
  • Author : Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel
  • Publisher : S Karger Ag
  • Release Date : 1996
  • ISBN : UOM:39015037798371
GET THIS BOOKImmunodeficient Animals

The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth