A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics

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  • Publisher : Academic Press
  • Release : 31 August 2018
  • ISBN : 9780128119211
  • Page : 544 pages
  • Rating : 4.5/5 from 103 voters

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A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies

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A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics
  • Author : Xiao-Dong Chen
  • Publisher : Academic Press
  • Release Date : 2018-08-31
  • ISBN : 9780128119211
GET THIS BOOKA Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use

Controversies in Latin American Bioethics

Controversies in Latin American Bioethics
  • Author : Eduardo Rivera-López,Martin Hevia
  • Publisher : Springer
  • Release Date : 2019-06-19
  • ISBN : 9783030179632
GET THIS BOOKControversies in Latin American Bioethics

This book offers a first rate selection of academic articles on Latin American bioethics. It covers different issues, such as vulnerability, abortion, biomedical research with human subjects, environment, exploitation, commodification, reproductive medicine, among others. Latin American bioethics has been, to an important extent, parochial and unable to meet stringent international standards of rational philosophical discussion. The new generations of bioethicists are changing this situation, and this book demonstrates that change. All articles are written from the perspective of Latin American

Advances in Contact Angle, Wettability and Adhesion

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  • Author : K. L. Mittal
  • Publisher : John Wiley & Sons
  • Release Date : 2019-10-16
  • ISBN : 9781119592556
GET THIS BOOKAdvances in Contact Angle, Wettability and Adhesion

This is the fourth volume in the series "Advances in Contact Angle, Wettability and Adhesion" initiated to consolidate information and provide commentary on certain recent research aspects dealing with this important topic. Its predecessor Volumes 1, 2 and 3 were published in 2013, 2015 and 2018 respectively. This new book comprising 14 research and review articles is divided into four parts: Part 1: Contact Angle and Wettability Aspects; Part 2: Surface Free Energy and Surface Tension Determination; Part 3: Applied Aspects. The topics covered include: Contact Angle Determination of Talc

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine
  • Author : Walter C. Low,Catherine M. Verfaillie
  • Publisher : World Scientific
  • Release Date : 2008
  • ISBN : 9789812775771
GET THIS BOOKStem Cells and Regenerative Medicine

The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues

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  • Author : Mariusz Z. Ratajczak
  • Publisher : Springer Nature
  • Release Date : 2020-01-02
  • ISBN : 9783030312060
GET THIS BOOKStem Cells

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells,

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  • Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
  • Publisher : Academic Press
  • Release Date : 2018-06-14
  • ISBN : 9780128120637
GET THIS BOOKPerinatal Stem Cells

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases,

Clinical Regenerative Medicine in Urology

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  • Author : Bup Wan Kim
  • Publisher : Springer
  • Release Date : 2017-09-14
  • ISBN : 9789811027239
GET THIS BOOKClinical Regenerative Medicine in Urology

This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After

Hematopoietic Cell Transplantation for Malignant Conditions

Hematopoietic Cell Transplantation for Malignant Conditions
  • Author : Qaiser Bashir,Mehdi Hamadani
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-02-14
  • ISBN : 9780323568036
GET THIS BOOKHematopoietic Cell Transplantation for Malignant Conditions

Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation.

The EBMT Handbook

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  • Publisher : Unknown
  • Release Date : 2020-10-08
  • ISBN : 1013273664
GET THIS BOOKThe EBMT Handbook

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and

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  • Author : Michael K. Danquah,Ram I. Mahato
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-14
  • ISBN : 9781627034173
GET THIS BOOKEmerging Trends in Cell and Gene Therapy

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills

Biology and Engineering of Stem Cell Niches

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  • Author : Ajaykumar Vishwakarma,Jeffrey M Karp
  • Publisher : Academic Press
  • Release Date : 2017-03-22
  • ISBN : 9780128027561
GET THIS BOOKBiology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based

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  • Author : Marcela Bolontrade,Mariana García
  • Publisher : Academic Press
  • Release Date : 2016-10-24
  • ISBN : 9780128031032
GET THIS BOOKMesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which

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  • Author : Rafael Pulido,Roland Lang
  • Publisher : MDPI
  • Release Date : 2019-11-28
  • ISBN : 9783039216888
GET THIS BOOKDual Specificity Phosphatases

Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the

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  • Publisher : Academic Press
  • Release Date : 2017-01-18
  • ISBN : 9780128025246
GET THIS BOOKMolecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms.

Regenerative Therapy Using Blood-Derived Stem Cells

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  • Author : David S. Allan,Dirk Strunk
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-16
  • ISBN : 1617794716
GET THIS BOOKRegenerative Therapy Using Blood-Derived Stem Cells

Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair